H2S, Polysulfides, and Enzymes: Physiological and Pathological Aspects

Nagahara, Noriyuki; Wróbel, Maria

doi:10.3390/biom10040640

Cited by 13 publications

(6 citation statements)

References 76 publications

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“…XO catalyzes S-nitrosothiols (RSNOs) to nitric oxide (NO), which reacts with a superoxide (O 2 −• ) anion to form peroxynitrite (ONOO − ) under aerobic conditions [ 123 ]. The properties of thiazate (NSO − ), thionitrite (SNO − ) isomers, nitrosopersulfide (SSNO − ) and polysulfides dinitrososulfites (Sulfi/NO), are to be determined and they appear to be a source of nitric oxide (NO) and nitroxyl (HNO) [ 140 , 141 , 142 ] ( Table 2 ).…”

Section: Oxidative Stressmentioning

confidence: 99%

Monitoring the Redox Status in Multiple Sclerosis

Tanaka

Vécsei

2020

Biomedicines

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Worldwide, over 2.2 million people suffer from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system. MS is characterized by a wide range of motor, autonomic, and psychobehavioral symptoms, including depression, anxiety, and dementia. The blood, cerebrospinal fluid, and postmortem brain samples of MS patients provide evidence on the disturbance of reduction-oxidation (redox) homeostasis, such as the alterations of oxidative and antioxidative enzyme activities and the presence of degradation products. This review article discusses the components of redox homeostasis, including reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products. The reactive chemical species cover frequently discussed reactive oxygen/nitrogen species, infrequently featured reactive chemicals such as sulfur, carbonyl, halogen, selenium, and nucleophilic species that potentially act as reductive, as well as pro-oxidative stressors. The antioxidative enzyme systems cover the nuclear factor erythroid-2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway. The NRF2 and other transcriptional factors potentially become a biomarker sensitive to the initial phase of oxidative stress. Altered components of the redox homeostasis in MS were discussed in search of a diagnostic, prognostic, predictive, and/or therapeutic biomarker. Finally, monitoring the battery of reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products helps to evaluate the redox status of MS patients to expedite the building of personalized treatment plans for the sake of a better quality of life.

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Section: Oxidative Stressmentioning

confidence: 99%

Monitoring the Redox Status in Multiple Sclerosis

Tanaka

Vécsei

2020

Biomedicines

View full text Add to dashboard Cite

show abstract

“…XO catalyzes S-nitrosothiols (RSNOs) to nitric oxide (NO), which reacts with a superoxide (O2 −• ) anion to form peroxynitrite (ONOO − ) under aerobic conditions [79]. The properties of thiazate (NSO − ), thionitrite (SNO − ) isomers, nitrosopersulfide (SSNO − ) and polysulfides dinitrososulfites (Sulfi/NO) are to be determined and they appear to be a source of nitric oxide (NO) and nitroxyl (HNO) [97] (Table 2).…”

Section: Reactive Sulfur Speciesmentioning

confidence: 99%

Monitoring the Redox Status in Multiple Sclerosis

Tanaka¹,

Vécsei²

2020

Preprint

View full text Add to dashboard Cite

Worldwide, over 2.2 million people are suffered from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system, characterized by multifocal inflammatory or demyelinating attacks associated with neuroinflammation and neurodegeneration. The blood, cerebrospinal fluid, and postmortem brain samples of MS patients evidenced the presence of reduction-oxidation (redox) homeostasis disturbance such as the alternations of oxidative and antioxidative enzyme activities and the presence of degradation products. This review article discussed the components of redox homeostasis including reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products. The reactive chemical species covered frequently discussed reactive oxygen/nitrogen species, rarely featured reactive chemicals such as sulfur, carbonyls, halogens, selenium, and nucleophilic species that potentially act as reductive as well as pro-oxidative stressors. The antioxidative enzyme systems covered the nuclear factor erythroid-2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway, a possible biomarker sensitive to the initial phase of oxidative stress. Altered components of the redox homeostasis in MS were discussed, some of which turned to be MS subtype- or treatment-specific and thus potentially become diagnostic, prognostic, predictive, and/or therapeutic biomarkers. Finally, monitoring a battery of redox components including oxidative, antioxidative and degradation products helps evaluate the redox status of MS patients, which expedites prolongation of remission, relapse prevention, and building personalized treatment plans.

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“…Increased activity and expression of iNOS in lymphocytes were found in active relapsing phase of RRMS [96]. CSF iNOS expression was shown in MS patients and mean CSF NOS activity was significantly higher, compared to controls [97] (Table 3) and nitroxyl (HNO) [108][109][110] (Table 2).…”

Section: Immunomodulators Interferon Beta (Ifn-β) Cismentioning

confidence: 99%

Monitoring the Redox Status in Multiple Sclerosis

Tanaka¹,

Vécsei²

2020

Preprint

View full text Add to dashboard Cite

Worldwide, over 2.2 million people are suffered from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system. MS is characterized by a wide range of motor, autonomic, and psychobehavioral symptoms including depression, anxiety, and dementia. The blood, cerebrospinal fluid, and postmortem brain samples of MS patients evidenced the disturbance of reduction-oxidation (redox) homeostasis such as the alterations of oxidative and antioxidative enzyme activities and the presence of degradation products. This review article discussed the components of redox homeostasis including reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products. The reactive chemical species covered frequently discussed reactive oxygen/nitrogen species, infrequently featured reactive chemicals such as sulfur, carbonyl, halogen, selenium, and nucleophilic species that potentially act as reductive as well as pro-oxidative stressors. The antioxidative enzyme systems covered the nuclear factor erythroid-2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway. The NRF2 and other transcriptional factors potentially become a biomarker sensitive to the initial phase of oxidative stress. Altered components of the redox homeostasis in MS were discussed in search of a diagnostic, prognostic, predictive, and/or therapeutic biomarker. Finally, monitoring a battery of reactive chemical species, oxidative enzymes, antioxidative enzymes and degradation products helps evaluate the redox status of MS patients to expedite building personalized treatment plans for the sake of better quality of life.

show abstract

H2S, Polysulfides, and Enzymes: Physiological and Pathological Aspects

Cited by 13 publications

References 76 publications

Monitoring the Redox Status in Multiple Sclerosis

Monitoring the Redox Status in Multiple Sclerosis

Monitoring the Redox Status in Multiple Sclerosis

Monitoring the Redox Status in Multiple Sclerosis

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