H2S-mediated inhibition of RhoA/ROCK pathway and noncoding RNAs in ischemic stroke

Lu, Weizhuo; Wen, Jiyue

doi:10.1007/s11011-022-01130-1

Cited by 4 publications

(2 citation statements)

References 125 publications

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“…RhoA has been identified as a negative regulator of neurite outgrowth during development, and its major downstream effector, Rock2, is associated with the induction of RhoA-driven neurite retraction [ 49 ]. RhoA/Rock2 upregulation contributes to neuroinflammation, blood-brain barrier dysfunction, axon growth inhibition and neuronal apoptosis following ischemic stroke [ 50 ]. Inhibition of RhoA/Rock2 signalling may effectively induce axonal regeneration following injury [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Focal ischemic stroke modifies microglia-derived exosomal miRNAs: potential role of mir-212-5p in neuronal protection and functional recovery

Li,

Wu,

Xing

et al. 2023

Biol Res

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Background Ischemic stroke is a severe type of stroke with high disability and mortality rates. In recent years, microglial exosome-derived miRNAs have been shown to be promising candidates for the treatment of ischemic brain injury and exert neuroprotective effects. Mechanisms underlying miRNA dysregulation in ischemic stroke are still being explored. Here, we aimed to verify whether miRNAs derived from exosomes exert effects on functional recovery. Methods MiR-212-5p agomir was employed to upregulate miR-212-5p expression in a rat model of middle cerebral artery occlusion/reperfusion (MCAO/R) as well as an oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro. Western blot analysis, qRT–PCR and immunofluorescence staining and other methods were applied to explore the underlying mechanisms of action of miR-212-5p. Results The results of our study found that intervention with miR-212-5p agomir effectively decreased infarct volume and restored motor function in MCAO/R rats. Mechanistically, miR-212-5p agomir significantly reduced the expression of PlexinA2 (PLXNA2). Additionally, the results obtained in vitro were similar to those achieved in vivo. Conclusion In conclusion, the present study indicated that PLXNA2 may be a target gene of miR-212-5p, and miR-212-5p has great potential as a target for the treatment and diagnosis of ischemic stroke.

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Section: Discussionmentioning

confidence: 99%

Focal ischemic stroke modifies microglia-derived exosomal miRNAs: potential role of mir-212-5p in neuronal protection and functional recovery

Li,

Wu,

Xing

et al. 2023

Biol Res

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“…NcRNAs can regulate several cellular processes, such as chromatin re-modeling, post-transcriptional modifications, and the regulation of signal transduction pathways, through targeting several target mRNAs simultaneously [ 17 , 19 , 29 , 30 ]. Recently, we and others have highlighted the potential roles of ncRNAs in regulating H 2 S biosynthesis in several physiological and pathological contexts [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. H 2 S and ncRNAs interact during the development and progression of several human diseases; therefore, their targeting can be of great therapeutic benefit [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review

Youness,

Habashy,

Khater

et al. 2024

ncRNA

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Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a “Maestro” role in orchestrating several oncological and non-oncological circuits and, thus, nominated them as possible therapeutic targets. Although a significant amount of work has been conducted on the role of nitric oxide (NO) and carbon monoxide (CO) and their inter-relationship in the field of oncology, research about hydrogen sulfide (H2S) remains in its infancy. Recently, non-coding RNAs (ncRNAs) have been reported to play a dominating role in the regulation of the endogenous machinery system of H2S in several pathological contexts. A growing list of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are leading the way as upstream regulators for H2S biosynthesis in different mammalian cells during the development and progression of human diseases; therefore, their targeting can be of great therapeutic benefit. In the current review, the authors shed the light onto the biosynthetic pathways of H2S and their regulation by miRNAs and lncRNAs in various oncological and non-oncological disorders.

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Targeting Non-Coding RNA for CNS Injuries: Regulation of Blood-Brain Barrier Functions

et al. 2023

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H2S-mediated inhibition of RhoA/ROCK pathway and noncoding RNAs in ischemic stroke

Cited by 4 publications

References 125 publications

Focal ischemic stroke modifies microglia-derived exosomal miRNAs: potential role of mir-212-5p in neuronal protection and functional recovery

Focal ischemic stroke modifies microglia-derived exosomal miRNAs: potential role of mir-212-5p in neuronal protection and functional recovery

Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review

Targeting Non-Coding RNA for CNS Injuries: Regulation of Blood-Brain Barrier Functions

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