H2S is a key antisecretory molecule against cholera toxin-induced diarrhoea in mice: Evidence for non-involvement of the AC/cAMP/PKA pathway and AMPK

Sousa, Francisca Beatriz M.; Souza, Luan Kelves Miranda de; Sousa, Nayara Alves de; Araújo, Thiago Souza; Araújo, Simone de; Pacífico, Dvison M.; Silva, Irismara S.; Silva, Renan O.; Nicolau, Lucas A.D.; Souza, Fabiana Moura; Filgueiras, Marcelo Carvalho; Oliveira, Jefferson Soares de; Souza, Marcellus H.; Medeiros, Jand Venes R.

doi:10.1016/j.niox.2017.09.007

Cited by 10 publications

(3 citation statements)

References 54 publications

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“…Inorganic sulfide salts, including CaS, Na 2 S, and NaHS, etc., have most widely been studied as H 2 S donors in medical studies [ 57 , 58 , 59 , 60 ]. Sulfide salts are generally solid analogs of the gas, which exist in the form of HS- anions and H 2 S molecules under the physiological condition.…”

Section: Generation and Metabolic Pathways Of H 2 Smentioning

confidence: 99%

Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease

Jiang

Ruan

et al. 2022

IJMS

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Hydrogen sulfide (H2S) has emerged as the third “gasotransmitters” and has a crucial function in the diversity of physiological functions in mammals. In particular, H2S is considered indispensable in preventing the development of liver inflammation in the case of excessive caloric ingestion. Note that the concentration of endogenous H2S was usually low, making it difficult to discern the precise biological functions. Therefore, exogenous delivery of H2S is conducive to probe the physiological and pathological roles of this gas in cellular and animal studies. In this review, the production and metabolic pathways of H2S in vivo, the types of donors currently used for H2S release, and study evidence of H2S improvement effects on nonalcoholic fatty liver disease are systematically introduced.

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Section: Generation and Metabolic Pathways Of H 2 Smentioning

confidence: 99%

Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease

Jiang

Ruan

et al. 2022

IJMS

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“…In addition to the molecules found, it is important to highlight the effect of hydrogen sulfide (H 2 S) on CT‐induced diarrhoea in mice. [ 135 ] H 2 S is a gaseous molecule that, despite its long history as a toxic gas and environmental pollutant, over the last few years has become recognized as an essential signalling molecule synthesized by mammalian tissues that plays several physiological roles and of a great importance for human health. [ 136 ] Sousa et al [ 135 ] using H 2 S donor molecules (NaHS and Lawesson's reagent) showed that H 2 S plays an essential role in protecting the intestinal mucosa in cholera toxin‐induced diarrhoea.…”

Section: Other Therapeutic Approachesmentioning

confidence: 99%

“…[ 135 ] H 2 S is a gaseous molecule that, despite its long history as a toxic gas and environmental pollutant, over the last few years has become recognized as an essential signalling molecule synthesized by mammalian tissues that plays several physiological roles and of a great importance for human health. [ 136 ] Sousa et al [ 135 ] using H 2 S donor molecules (NaHS and Lawesson's reagent) showed that H 2 S plays an essential role in protecting the intestinal mucosa in cholera toxin‐induced diarrhoea. The use of H 2 S donor molecules represents a promising therapeutic strategy, considering that this mediator is produced endogenously at low levels, in micromolar concentration of H 2 S, an amount considered as toxicologically safe and which has relevant physiological and pathophysiological effects.…”

Section: Other Therapeutic Approachesmentioning

confidence: 99%

A comprehensive review of therapeutic approaches available for the treatment of cholera

Sousa

Nolêto

Chaves

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives The oral rehydration solution is the most efficient method to treat cholera; however, it does not interfere in the action mechanism of the main virulence factor produced by Vibrio cholerae, the cholera toxin (CT), and this disease still stands out as a problem for human health worldwide. This review aimed to describe therapeutic alternatives available in the literature, especially those related to the search for molecules acting upon the physiopathology of cholera. Key findings New molecules have offered a protection effect against diarrhoea induced by CT or even by infection from V. cholerae. The receptor regulator cystic fibrosis channel transmembrane (CFTR), monosialoganglioside (GM1), enkephalinase, AMP-activated protein kinase (AMPK), inhibitors of expression of virulence factors and activators of ADP-ribosylarginine hydrolase are the main therapeutic targets studied. Many of these molecules or extracts still present unclear action mechanisms. Conclusions Knowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution.

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The Role of H2S in the Gastrointestinal Tract and Microbiota

Xiao

Liu

2021

Advances in Experimental Medicine and Biology

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H2S is a key antisecretory molecule against cholera toxin-induced diarrhoea in mice: Evidence for non-involvement of the AC/cAMP/PKA pathway and AMPK

Cited by 10 publications

References 54 publications

Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease

Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease

A comprehensive review of therapeutic approaches available for the treatment of cholera

The Role of H2S in the Gastrointestinal Tract and Microbiota

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