H2S and Inflammation: An Overview

Bhatia, Madhav

doi:10.1007/978-3-319-18144-8_8

Cited by 65 publications

(47 citation statements)

References 60 publications

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“…In the broader context of effects in humans, the role of H 2 S in inflammation is controversial both in vitro and in vivo . H 2 S has been shown to increase proinflammatory cytokine expression in human monocytes via the ERK–NF‐κB pathway .…”

Section: Discussionmentioning

confidence: 99%

Cobinamide is effective for treatment of hydrogen sulfide–induced neurological sequelae in a mouse model

Anantharam

Whitley²,

Mahama

et al. 2017

Annals of the New York Academy of Sciences

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Hydrogen sulfide (H2S) is a highly neurotoxic gas. Acute exposure can lead to neurological sequelae among survivors. A drug for treating neurological sequelae in survivors of acute H2S intoxication is needed. Using a novel mouse model we evaluated the efficacy of cobinamide (Cob) for this purpose. There were two objectives: (1) to determine the dose–response efficacy of Cob and (2) to determine the effective therapeutic time window of Cob. To explore objective 1, mice were injected intramuscularly with Cob at 0, 50 or 100 mg/kg at 2 min after H2S exposure. For objective 2, mice were injected intramuscularly with 100 mg/kg Cob at 2, 15, and 30 min after H2S exposure. For both objectives, mice were exposed to 765 ppm of H2S gas. Cob significantly reduced H2S-induced lethality in a dose-dependent manner (P < 0.05). Cob-treated mice exhibited significantly fewer seizures and knockdowns compared with the H2S-exposed group. Cob also reversed H2S-induced weight loss, behavioral deficits, neurochemical changes, cytochrome c oxidase enzyme inhibition, and neurodegeneration in a dose- and time-dependent manner (P < 0.01). Overall, these findings show that Cob increases survival and is neuroprotective in a mouse model of H2S-induced neurological sequelae.

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Section: Discussionmentioning

confidence: 99%

Cobinamide is effective for treatment of hydrogen sulfide–induced neurological sequelae in a mouse model

Anantharam

Whitley²,

Mahama

et al. 2017

Annals of the New York Academy of Sciences

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“…Bhatia [86] reported that H 2 S acts as a novel mediator of inflammation. Soria et al [87] determined that sulphurous mineral water intake improves haematological and biochemical markers of muscle damage produced in response to endurance exercise in well-trained athletes and thus may protect from exercise-induced muscle damage.…”

Section: Cell and Immunological Messengersmentioning

confidence: 99%

Sulphurous Mineral Waters: New Applications for Health

Carbajo

Maraver

2017

Evidence-Based Complementary and Alternative Medicine

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Sulphurous mineral waters have been traditionally used in medical hydrology as treatment for skin, respiratory, and musculoskeletal disorders. However, driven by recent intense research efforts, topical treatments are starting to show benefits for pulmonary hypertension, arterial hypertension, atherosclerosis, ischemia-reperfusion injury, heart failure, peptic ulcer, and acute and chronic inflammatory diseases. The beneficial effects of sulphurous mineral waters, sulphurous mud, or peloids made from sulphurous mineral water have been attributed to the presence of sulphur mainly in the form of hydrogen sulphide. This form is largely available in conditions of low pH when oxygen concentrations are also low. In the organism, small amounts of hydrogen sulphide are produced by some cells where they have numerous biological signalling functions. While high levels of hydrogen sulphide are extremely toxic, enzymes in the body are capable of detoxifying it by oxidation to harmless sulphate. Hence, low levels of hydrogen sulphide may be tolerated indefinitely. In this paper, we review the chemistry and actions of hydrogen sulphide in sulphurous mineral waters and its natural role in body physiology. This is followed by an update of available data on the impacts of exogenous hydrogen sulphide on the skin and internal cells and organs including new therapeutic possibilities of sulphurous mineral waters and their peloids.

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“…Furthermore, sulfur donors are being attached to current drug treatments, such as naproxen, improving their anti-inflammatory effectiveness and decreasing gastrointestinal and cardiovascular side effects (13,19,35,42,105). H 2 S has beneficial effects in other organs including neurons, kidney, pancreas, and gastrointestinal and in arthritis (15,43). This suggests organ-specific delivery systems for H 2 S may need to be developed to localize therapeutic effects.…”

Section: H 2 S Mitigates Pathological Cardiac Remodeling By Inhibitinmentioning

confidence: 99%