H2O2 modulates twitch tension and increases Po of Ca2+ release channel in frog skeletal muscle

Ôba, Toshiharu; Koshita, Makoto; Yamaguchi, Mamoru

doi:10.1152/ajpcell.1996.271.3.c810

Cited by 59 publications

(65 citation statements)

References 25 publications

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“…For instance, we found an increase of resting cytosolic Ca 2+ concentration in aged rats (Fraysse et al 2006). Hydrogen peroxide affects the structure and activity of the dihydropyridine and ryanodine receptors and consequently modifies calcium release and muscle contraction (Oba et al 1996;Espinosa et al 2006). The oxidation of SH groups alters L-type channel gating with a reduction of calcium currents in cardiac cells (Lacampagne et al 1995).…”

Section: Introductionmentioning

confidence: 83%

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

Pierno

Tricarico

Liantonio

et al. 2013

AGE

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Age-related skeletal muscle decline is characterized by the modification of sarcolemma ion channels important to sustain fiber excitability and to prevent metabolic dysfunction. Also, calcium homeostasis and contractile function are impaired. In the aim to understand whether these modifications are related to oxidative damage and can be reverted by antioxidant treatment, we examined the effects of in vivo treatment with an waste water polyphenolic mixture (LACHI MIX HT) supplied by LACHIFARMA S.r.l. Italy containing hydroxytirosol (HT), gallic acid, and homovanillic acid on the skeletal muscles of 27-month-old rats. After 6-week treatment, we found an improvement of chloride ClC-1 channel conductance, pivotal for membrane electrical stability, and of ATP-dependent potassium channel activity, important in coupling excitability with fiber metabolism. Both of them were analyzed using electrophysiological techniques. The treatment also restored the resting cytosolic calcium concentration, the sarcoplasmic reticulum calcium release, and the mechanical threshold for contraction, an index of excitation-contraction coupling mechanism. Muscle weight and blood creatine kinase levels were preserved in LACHI MIX HT-treated aged rats. The antioxidant activity of LACHI MIX HT was confirmed by the reduction of malondialdehyde levels in the brain of the LACHI MIX HT-treated aged rats. In comparison, the administration of purified HT was less effective on all the parameters studied. Although muscle function was not completely recovered, the present study provides evidence of the beneficial effects of LACHI MIX HT, a natural compound, to ameliorate skeletal muscle functional decline due to aging-associated oxidative stress.

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Section: Introductionmentioning

confidence: 83%

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

Pierno

Tricarico

Liantonio

et al. 2013

AGE

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“…Oba et al (Oba et al, 1996) reported that incubation of intact single frog fibers in a solution containing H 2 O 2 induced a biphasic effect on muscle force. Initially, muscle force increased, but as the exposure to H 2 O 2 continued, muscle force declined (Oba et al, 1996). Likewise, Andrade et al (Andrade et al, 1998) reported that single mouse fibers responded to H 2 O 2 exposure in a time-dependent manner, showing biphasic changes.…”

Section: Integrating the Redox Homeostasis Responses To Exercise Withmentioning

confidence: 99%

“…Shortly afterwards, several studies verified this hormetic effect of reactive species on muscle force. Oba et al (Oba et al, 1996) reported that incubation of intact single frog fibers in a solution containing H 2 O 2 induced a biphasic effect on muscle force. Initially, muscle force increased, but as the exposure to H 2 O 2 continued, muscle force declined (Oba et al, 1996).…”

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confidence: 99%

Redox biology of exercise: an integrative and comparative consideration of some overlooked issues

Nikolaidis

Kyparos

Spanou

et al. 2012

Journal of Experimental Biology

124

152

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SummaryThe central aim of this review is to address the highly multidisciplinary topic of redox biology as related to exercise using an integrative and comparative approach rather than focusing on blood, skeletal muscle or humans. An attempt is also made to redefine ʻoxidative stressʼ as well as to introduce the term ʻalterations in redox homeostasisʼ to describe changes in redox homeostasis indicating oxidative stress, reductive stress or both. The literature analysis shows that the effects of non-muscledamaging exercise and muscle-damaging exercise on redox homeostasis are completely different. Non-muscle-damaging exercise induces alterations in redox homeostasis that last a few hours post exercise, whereas muscle-damaging exercise causes alterations in redox homeostasis that may persist for and/or appear several days post exercise. Both exhaustive maximal exercise lasting only 30s and isometric exercise lasting 1-3min (the latter activating in addition a small muscle mass) induce systemic oxidative stress. With the necessary modifications, exercise is capable of inducing redox homeostasis alterations in all fluids, cells, tissues and organs studied so far, irrespective of strains and species. More importantly, ʻexercise-induced oxidative stressʼ is not an ʻoddityʼ associated with a particular type of exercise, tissue or species. Rather, oxidative stress constitutes a ubiquitous fundamental biological response to the alteration of redox homeostasis imposed by exercise. The hormesis concept could provide an interpretative framework to reconcile differences that emerge among studies in the field of exercise redox biology. Integrative and comparative approaches can help determine the interactions of key redox responses at multiple levels of biological organization.Key words: antioxidant, biomarker, eccentric, free radical, training. THE JOURNAL OF EXPERIMENTAL BIOLOGY 1616The ʻgoodʼ (antioxidants), the ʻbadʼ (reactive species) and the ʻuglyʼ (oxidative stress) 1 The distinction drawn in the section heading is schematically used to parody the popular manichaeistic view that antioxidants are considered 'useful' entities, reactive species are considered 'harmful' entities and oxidative stress is considered a 'negative' state. Certainly, the reality is much more complicated and antioxidants, reactive species and oxidative stress can serve both useful and detrimental roles, which are dependent on the biological context (within an organism), which in turn are greatly dependent on the environmental context (outside an organism). AntioxidantsAdmittedly, to define the term 'antioxidant' is a difficult task. In this paper, antioxidant is defined as any mechanism, structure and/or substance that delays, prevents or removes oxidative modifications to a target molecule (Halliwell and Gutteridge, 2007;Pamplona and Costantini, 2011). Antioxidants can be complex molecules such as the superoxide dismutases and peroxiredoxins, or simpler ones such as uric acid and glutathione (Gutteridge and Halliwell, 2010). They can be broa...

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“…Thus the RYR channel, which contains sensitive SH groups, appears a likely target for modification. It has been directly demonstrated that the skeletal muscle RYR channel is sensitive to singlet oxygen (122), hydrogen peroxide (48,99) and hypochlorous acid (128). Recently, Oba et al (99) demonstrated that hydrogen peroxide initially potentiated twitch tension.…”

Section: Failure Of Sr Ca 2ϩ Release and Muscle Fatiguementioning

confidence: 99%

Sarcoplasmic reticulum Ca²⁺release and muscle fatigue

Favero

1999

Journal of Applied Physiology

109

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Efforts to examine the relevant mechanisms involved in skeletal muscle fatigue are focusing on Ca2+ handling within the active muscle cell. It has been demonstrated time and again that reductions in sarcoplasmic reticulum (SR) Ca2+release resulting from increased or intense muscle contraction will compromise tension development. This review seeks to accomplish two related goals: 1) to provide an up-to-date molecular understanding of the Ca2+-release process, with considerable attention devoted to the SR Ca2+ channel, including its associated proteins and their regulation by endogenous compounds; and 2) to examine several putative mechanisms by which cellular alterations resulting from intense and/or prolonged contractile activity will modify SR Ca2+ release. The mechanisms that are likely candidates to explain the reductions in SR Ca2+ channel function following contractile activity include elevated Ca2+ concentrations, alterations in metabolic homeostasis within the “microcompartmentalized” triadic space, and modification by reactive oxygen species.

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H2O2 modulates twitch tension and increases Po of Ca2+ release channel in frog skeletal muscle

Cited by 59 publications

References 25 publications

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

Redox biology of exercise: an integrative and comparative consideration of some overlooked issues

Sarcoplasmic reticulum Ca²⁺release and muscle fatigue

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H2O2 modulates twitch tension and increases Po of Ca2+ release channel in frog skeletal muscle

Cited by 59 publications

References 25 publications

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

Redox biology of exercise: an integrative and comparative consideration of some overlooked issues

Sarcoplasmic reticulum Ca2+release and muscle fatigue

Contact Info

Product

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Sarcoplasmic reticulum Ca²⁺release and muscle fatigue