H2FPEF score predicts 1-year rehospitalisation of patients with heart failure with preserved ejection fraction

Abstract

BackgroundHeart failure with preserved ejection fraction (HFpEF) has received widespread attention in recent years. There is currently a lack of valuable predictors for the prognosis of this disease. Here, we aimed to identify a non-invasive scoring system that can effectively predict 1-year rehospitalisation for patients with HFpEF.MethodsWe included 151 consecutive patients with HFpEF in a prospective cohort study and investigated the association between H2FPEF score and 1-year readmission for heart failure using multivariate Cox regression analysis.ResultsOur findings indicated that obesity, age >70 years, treatment with ≥2 antihypertensives, echocardiographic E/e’ ratio >9 and pulmonary artery pressure >35 mm Hg were independent predictors of 1-year readmission. Three models (support vector machine, decision tree in R and Cox regression analysis) proved that H2FPEF score could effectively predict 1-year readmission for patients with HFpEF (area under the curve, 0.910, 0.899 and 0.771, respectively; p<0.001).ConclusionOur study demonstrates that the H2FPEF score has excellent predictive value for 1-year rehospitalisation of patients with HFpEF.

Predictive value of H2FPEF score in patients with heart failure with preserved ejection fraction

“…Two studies have previously examined the relationship between H 2 FPEF score and adverse outcomes. According to Tao et al ., the H 2 FPEF score had excellent predictive value for 1‐year rehospitalization of patients with HFpEF 19 . Our study also revealed the relationship between H 2 FPEF score and rehospitalization; however, the differences among the three groups appeared until 24 months after discharge.…”

“…According to Tao et al, the H 2 FPEF score had excellent predictive value for 1-year rehospitalization of patients with HFpEF. 19 Our study also revealed the relationship between H 2 FPEF score and rehospitalization; however, the differences among the three groups appeared until 24 months after discharge. This discrepancy between the two studies may be attributed to different baseline characteristics of the cohort of the previous study, namely, older age, fewer females, a higher frequency of hypertension and AF, and worse cardiac function.…”

On the search for the right definition of heart failure with preserved ejection fraction

“…In subsequent studies, the H 2 FPEF score showed high sensitivity for clinically ascertained diagnosis of HFpEF, as well as predictive value for future HF-related events both in HFpEF and in non-HF patients with cardiovascular risk factors [57][58][59][60].…”

Prognostic value of the H2FPEF score in patients undergoing transcatheter aortic valve implantation

“…9 Moreover, it has been demonstrated that the H 2 FPEF score is able to predict adverse outcome in heart failure patients. [10][11][12][13] Aortic stenosis (AS) is a frequent finding, especially among elderly patients, and severe AS is associated with dismal outcome if left untreated. 14,15 Pathophysiologically, left ventricular (LV) pressure overload due to obstructed outflow through the calcified aortic valve is usually associated with concentric LV hypertrophy.…”

“…To overcome this shortcoming, the so‐called H 2 FPEF score has recently been published enabling the diagnosis of HFpEF with high accuracy using simple demographic, clinical, and echocardiographic parameters 9 . Moreover, it has been demonstrated that the H 2 FPEF score is able to predict adverse outcome in heart failure patients 10–13 …”