H2BFWT Variations in Sperm DNA and Its Correlation to Pregnancy
Houda Amor,
Ingolf Juhasz-Böss,
Riffat Bibi
et al.
Abstract:Abnormalities in sperm nuclei and chromatin can interfere with normal fertilization, embryonic development, implantation, and pregnancy. We aimed in this study to determine the impact of H2BFWT gene variants in sperm DNA on ICSI outcomes in couples undergoing ART treatment. One hundred and nineteen partners were divided into pregnant (G1) and non-pregnant (G2) groups. After semen analysis, complete DNA was extracted from purified sperm samples. The sequence of the H2BFWT gene was amplified by PCR and then subj… Show more
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