H105A peptide eye drops promote photoreceptor survival in murine and human models of retinal degeneration
Alexandra Bernardo-Colón,
Andrea Bighinati,
Shama Parween
et al.
Abstract:Photoreceptor death causes blinding inheritable retinal diseases, such as retinitis pigmentosa (RP). As disease progression often outpaces therapeutic advances, finding effective treatments is urgent. This study focuses on developing a targeted approach by evaluating the efficacy of small peptides derived from pigment epithelium-derived factor (PEDF), known to restrict common cell death pathways associated with retinal diseases. Peptides with affinity for the PEDF receptor, PEDF-R, (17-mer and H105A) delivered… Show more
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