H1- and H2-histamine receptor—mediated vasodilation varies with aging in humans*

Bedarida, Gabriella; Bushell, Erin; Blaschke, Terrence F.; Hoffman, Brian B.

doi:10.1016/0009-9236(95)90074-8

Cited by 11 publications

(7 citation statements)

References 31 publications

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“…Finally, amitriptyline has affinity not only for noradrenaline uptake and el-adrenoceptors, but also for muscarinic cholinoceptors and H1 histamine receptors (Hall and CIgren 1981;Richelson and Nelson 1984). There is evidence both for venodilator muscarinic (Collier et al 1972;Kongpatanakul et al 1992) and H1 histamine receptors (Dachman et al 1994;Bedarida et al 1995) in the dorsal hand vein. Although, in theory, the blockade of these receptors by amitriptyline could have caused an increase in the size of the response to noradrenaline, the same mechanism would have increased the size of the responses to methoxamine as well.…”

Section: Discussionmentioning

confidence: 99%

The opposite effects of amitriptyline on noradrenaline-and methoxamine-evoked venoconstriction in man

Szabadi

et al. 1996

Naunyn-Schmiedeberg's Arch Pharmacol

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The effects of a single oral dose (100 mg) of amitriptyline on noradrenaline- and methoxamine-evoked venoconstriction were compared, using the dorsal hand vein compliance technique, in 8 healthy male volunteers. Both noradrenaline and methoxamine produced dose-dependent venoconstriction; the geometric mean ED50 for noradrenaline was 4.15 ng min-1 and for methoxamine was 1143.54 ng min-1; the potency ratio (noradrenaline/methoxamine) was 277. Amitriptyline shifted the dose-response curve for noradrenaline to the left (ANOVA: P < 0.025; dose-ratio: 0.38) consistent with potentiation, and the dose-response curve for methoxamine to the right (ANOVA: P < 0.025; dose ratio: 2.72) consistent with antagonism. The potentiation is likely to be due to noradrenaline uptake blockade, whereas the antagonism is likely to reflect the blockade of post-junctional alpha 1-adrenoceptors.

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Section: Discussionmentioning

confidence: 99%

The opposite effects of amitriptyline on noradrenaline-and methoxamine-evoked venoconstriction in man

Szabadi

et al. 1996

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Histamine challenge in migraine patients and healthy volunteers, respectively, induced a migraine attack and headache (25–27). Histamine is a potent vasoactive compound (28–35), and since the headache of a migraine attack has been attributed to cerebrovascular vasodilation (36–39), histamine may be a candidate mediator for vascular changes observed during a migraine attack. There is evidence that the vascular effects of histamine are at least partially mediated by nitric oxide (NO) (40), a gaseous molecule with a potential important role in development of migraine.…”

Section: Methodsmentioning

confidence: 99%

Migraine and Function of the Immune System: A Meta-Analysis of Clinical Literature Published Between 1966 and 1999

et al. 2001

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Mechanisms underlying migraine precipitation are largely unknown. A role of the immune system in migraine precipitation is a matter of debate because of the association of atopic disorders and migraine. Recently, it was demonstrated that migraineurs benefit from eradication of a Helicobacter pylori infection, which substantiates a possible role for (sub-clinical) infections in precipitation of migraine. Since 1966, about 45 clinical investigations have reported on alterations of immune function in migraine patients, which we present in this review. Changes of serum levels of complement and immunoglobulins, histamine, cytokines and immune cells were found in some of these studies but in most cases not corroborated by others. Migraineurs suffering from comorbid atopic disorders show elevated plasma IgE levels but not patients without a type I hypersensitivity. Histamine plasma levels are chronically elevated in migraineurs, and interictally decreased lymphocyte phagocytotic function and increased plasma tumor necrosis factor alpha (TNFalpha) levels were found, and may be related to increased infection susceptibility. The cause of this increased susceptibility is unclear but most likely is a result of chronic stress, a well-known suppressor of the immune system. Stress relief enhances immune activity and triggers a burst of circulating vasoactive compounds that function as mediators of inflammation and potential precipitators of a migraine attack in vulnerable subjects. In conclusion, in the clinical literature of the past decades, there is no clear-cut evidence of an immune dysfunction in migraineurs, but we cannot totally exclude the possibility of an altered immune function in migraineurs. Discrepancies in the literature most likely are caused by the divergent patterns of sample collection relative to the time of the attack. We propose stringent definition of sample collection times for future studies of immune function in migraine patients.

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“…In the human brain, similar observations were noted, where the H1 receptor subtype showed significant decreases with age 24 . The ability of histamine to induce vasodilation via the activation of H1 and H2 receptors is also altered with age 25 . The authors demonstrated that ageing has a direct effect on the signal transduction pathway activated via the H2 receptor while maintaining the function of H1 receptor.…”

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confidence: 99%

Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues

Štromberga

Chess-Williams

Moro

2020

Sci Rep

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Russ chess-Williams & christian Moro * Inflammatory mediators may have a role in various lower urinary tract disorders. Histamine is known to induce significant increases in both the tension and frequency of spontaneous phasic contractions in both urothelium with lamina propria (U&LP) and detrusor muscle via the activation of H1 receptor in juvenile animal models. However, it is unclear whether age affects these contractile responses to histamine. This study assessed the histamine receptor subtypes mediating contraction in juvenile and adult porcine bladders and compared the urothelium with lamina propria and detrusor responses to histamine. Isolated tissue bath studies were conducted using strips of porcine U&LP and detrusor obtained from juvenile (6 months) and adult (3 years) animals exposed to histamine receptor agonists and antagonists. Treatment with histamine (100 µM) in U&LP of juvenile animals caused increases in baseline tension by 47.84 ± 6.52 mN/g (p < 0.001, n = 51) and by 50.76 ± 4.10 mN/g (p < 0.001, n = 55) in adult animals. Furthermore, the frequency of spontaneous phasic contractions was significantly enhanced in response to histamine in U&LP of both juvenile and adult tissues (p < 0.001 for both age groups). Treatment with an H2 agonist in U&LP of juvenile animals decreased baseline tension by 13.97 ± 3.45 mN/g (n = 12, p < 0.05), but had no effect in adult animals. Inhibition of H1 receptors resulted in significantly reduced contractile responses of U&LP and detrusor to histamine in both juvenile and adult animals (p < 0.05). Treatment with an H2 receptor antagonist significantly enhanced contractions in juvenile preparations (n = 10, p < 0.05) but had no effect in adult preparations (n = 8). In detrusor, treatment with histamine (100 µM) in juvenile tissues showed a significantly higher increase in baseline tension of 19.10 ± 4.92 mN/g (n = 51) when compared to adult tissues exhibiting increases of 8.21 ± 0.89 mN/g (n = 56, p < 0.05). The increases in the baseline tension were significantly inhibited by the presence of H1 receptor antagonists in both juvenile and adult detrusor preparations. Treatment with either the H2 receptor antagonist or agonist in detrusor had no effect on both juvenile and adult tissues. Therefore, the histamine receptor system may play an essential role in the maintenance of bladder function or in bladder dysfunction observed in some lower urinary tract disorders. Normal bladder function deteriorates throughout adult life, age appearing to have a direct effect on bladder sensation, contractility and the ability to postpone voiding 1. Ageing is associated with several changes that occur in the urinary bladder, such as a reduction in bladder capacity 2 and an increase in bladder sensitisation 3. It is also linked with marked increases in the prevalence of lower urinary tract symptoms, such as urinary frequency, voiding difficulties, decreased bladder contractions (as seen in underactive bladder) or uninhibited bladder contractions (as seen in overactive bladder) 1. Urin...

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H1- and H2-histamine receptor—mediated vasodilation varies with aging in humans*

Cited by 11 publications

References 31 publications

The opposite effects of amitriptyline on noradrenaline-and methoxamine-evoked venoconstriction in man

The opposite effects of amitriptyline on noradrenaline-and methoxamine-evoked venoconstriction in man

Migraine and Function of the Immune System: A Meta-Analysis of Clinical Literature Published Between 1966 and 1999

Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues

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