H. pylori infection increases gastric mucosal COX2 and mTOR expression in chronic gastritis: Implications for cancer progression?

Badary, Dalia M.; Rahma, Mohammed Zakaria Ali Abu; Ashmawy, Ahmed M; Hafez, Mohamed Zain Eldeen

doi:10.1016/j.pathophys.2017.05.004

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…The inhibition of ROS production, associated with the inactivation of NF‐κB signaling, has been pointed as a therapeutic target for numerous inflammatory diseases . This transcription factor regulates the expression of several inflammatory mediators including enzymes such as COX‐2, NOS‐2, and HO‐1, which have been also associated with gastric cancer . Supporting the role of HPU as a pro‐inflammatory factor, we observed an increasing expression of pro‐IL‐1β, COX‐2, and HO‐1, as consequences of NF‐κB activation.…”

Section: Discussionsupporting

confidence: 63%

“…53 This transcription factor regulates the expression of several inflammatory mediators including enzymes such as COX-2, NOS-2, and HO-1, which have been also associated with gastric cancer. [54][55][56][57][58][59] Supporting the role of HPU as a pro-inflammatory factor, we observed an increasing expression of pro-IL-1β, COX-2, and HO-1, as consequences of NF-κB activation. Although HPU has increased NO production by endothelial cells, an effect inhibited by esculetin, we could not detect iNOS expression (data not shown), suggesting that perhaps HPU may be signaling to activate eNOS, through intracellular ROS production.…”

Section: Discussionsupporting

confidence: 61%

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Helicobacter pylori urease induces pro‐inflammatory effects and differentiation of human endothelial cells: Cellular and molecular mechanism

et al. 2019

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Background Helicobacter pylori urease (HPU) is a key virulence factor that enables bacteria to colonize and survive in the stomach. We early demonstrated that HPU, independent of its catalytic activity, induced inflammatory and angiogenic responses in vivo and directly activated human neutrophils to produce reactive oxygen species (ROS). We have investigated the effects of HPU on endothelial cells, focusing on the signaling mechanism involved. Methods Monolayers of human microvascular endothelial cells (HMEC‐1) were stimulated with HPU (up to 10 nmol/L): Paracellular permeability was accessed through dextran‐FITC passage. NO and ROS production was evaluated using intracellular probes. Proteins or mRNA expressions were detected by Western blotting and fluorescence microscopy or qPCR assays, respectively. Results Treatment with HPU enhanced paracellular permeability of HMEC‐1, preceded by VE‐cadherin phosphorylation and its dissociation from cell‐cell junctions. This caused profound alterations in actin cytoskeleton dynamics and focal adhesion kinase (FAK) phosphorylation. HPU triggered ROS and nitric oxide (NO) production by endothelial cells. Increased intracellular ROS resulted in nuclear factor kappa B (NF‐κB) activation and upregulated expression of cyclooxygenase‐2 (COX‐2), hemeoxygenase‐1 (HO‐1), interleukin‐1β (IL‐1β), and intercellular adhesion molecule‐1 (ICAM‐1). Higher ICAM‐1 and E‐selectin expression was associated with increased neutrophil adhesion on HPU‐stimulated HMEC monolayers. The effects of HPU on endothelial cells were dependent on ROS production and lipoxygenase pathway activation, being inhibited by esculetin. Additionally, HPU improved vascular endothelial growth factor receptor 2 (VEGFR‐2) expression. Conclusion The data suggest that the pro‐inflammatory properties of HPU drive endothelial cell to a ROS‐dependent program of differentiation that contributes to the progression of H pylori infection.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionsupporting

confidence: 61%

Helicobacter pylori urease induces pro‐inflammatory effects and differentiation of human endothelial cells: Cellular and molecular mechanism

et al. 2019

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“…En general, los médicos deben tener una preparación idónea que les permita tratar, desde el punto de vista científico, las distintas patologías que afectan al ser humano, que cuentan además con instrumentos tecnológicos y un arsenal farmacológico suficiente para enfrentar múltiples dolencias, como la gastritis crónica generada por la bacteria Helicobacter pylori (22) o para atenuar las manifestaciones clínicas ocasionadas por el desarrollo de la enfermedad de Parkinson (23), o en la utilización de métodos efectivos para el control de la natalidad (24). Así las cosas, los médicos tratantes ya no tienen que recurrir al conjuro y la invocación de espíritus o deidades para procurar la sanación, como se hacía en la antigüedad.…”

Section: Discussionunclassified

La delusión médica: ¿curación por fe en un Dios o por una práctica médica apropiada?

Parra

Ríos

Quintero

2022

Med.

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El objetivo del presente trabajo fue analizar los elementos objetivos y subjetivos presentados en la historia de la medicina, sobre la curación o mejora de la salud, asociados a creencias religiosas y antagonismo con las consideraciones científicas que se realizan en la medicina, como resultado exitoso o fallido en los procedimientos médico-quirúrgicos durante el trabajo de estos profesionales de la salud. En la actualidad, se fomenta la intervención de las deidades como elementos manipuladores en la conservación de la salud y se reivindica el acto científico humanístico como antítesis de la tradición que vincula el acto médico por la acción de las deidades. Se concluye que ya no se realizan en el campo médico invocaciones de entidades sobrenaturales como dios, dioses o santos para la mejora de los pacientes, pero si se vuelve más objetivo con el apoyo del conocimiento científico que permite interpretar más objetivamente al paciente y guiar la terapia adecuada.

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“…The main reason for this is the increasing severity of chronic gastric inflammation due to the longterm presence of H. Pylori. Chronic stomach inflammation may get the tissues to lose their natural state and enter a pathway towards cancer (4). In this pathway, some subgroups of H. Pylori related inflammation contribute significantly.…”

Section: Discussionmentioning

confidence: 99%

“…The second is the low eradication rate due to antibiotic resistance caused by the inability to use the drugs given in sufficient amount and duration and the inadequate use of these drugs due to toxic side effects (2). H. Pylori can cause many diseases ranging from a mild problem such as simple ulceration to gastric cancer in some individuals according to genetic predisposition, as well as problems in many organs outside of the stomach in various degrees of tissue (3,4).…”

Section: Introductionmentioning

confidence: 99%

Is There Any Relationship Between Circulating Serum 25-Hydroxyvitamin D Level and Presence of Helicobacter Pylori As Well As Gastric Inflammation Severity?

Akar¹

2019

Ulutas Med J

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H. pylori infection increases gastric mucosal COX2 and mTOR expression in chronic gastritis: Implications for cancer progression?

Cited by 8 publications

References 18 publications

Helicobacter pylori urease induces pro‐inflammatory effects and differentiation of human endothelial cells: Cellular and molecular mechanism

Helicobacter pylori urease induces pro‐inflammatory effects and differentiation of human endothelial cells: Cellular and molecular mechanism

La delusión médica: ¿curación por fe en un Dios o por una práctica médica apropiada?

Is There Any Relationship Between Circulating Serum 25-Hydroxyvitamin D Level and Presence of Helicobacter Pylori As Well As Gastric Inflammation Severity?

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