H. pylori infection and the development of gastric cancer

Abstract

Abstract. BACKGROUND: Recently, many study have shown that Helicobacter pylori infection is crucial in development of atrophic gastritis, which is closely associated with gastric cancer. We con ducted a long-term endoscopic prospective follow-up study to investigate the development of gastric cancer in H. pylori-positive and -negative patients. METHODS: 1603 patients who underwent endos -copy and were assessed as to the presence of H. pylori infection by histology, rapid urease test and serologic test between April 1990 and March 1993 were entered. We prospectively studied 1246 sub jects with and 280 subjects without H. pylori infection for a mean follow-up of 7.8 years (range 1-10.6 years). RESULTS: Gastric cancer of both the intestinal and diffuse type developed in 36 (2.9%) infected patients but in none of the uninfected patients during follow-up. There was an increased risk for gastric cancer in infected patients with severe gastric atrophy and corpus predominant gastritis and intestinal metaplasia. Gastric cancer was detected in 21 (4.7%) of the patients with non ulcer dyspepsia, in 10 (3.4%) of those with gastric ulcer and in 5 (2.2%) of those with gastric hyperplastic polyp, at en rollment. No gastric cancer was detected in duodenal ulcer patients. CONCLUSION: These results suggest that the development of both types of gastric cancer is caused by H. pylori-associated gastritis, and the risk for development of gastric cancer in H. pylori-negative subjects is extremely low. Subjects having H. pylori-positive gastric mucosa with severe atrophy and/or corpus gastritis may be at partic ularly high risk for gastric cancer.

Influence of EPIYA-Repeat Polymorphism on the Phosphorylation-Dependent Biological Activity of Helicobacter pylori CagA

“…1,2 Recent studies ha ve shown that the d eve lopment o f gastr ic carcinoma is dep end ent o n genetic fa ctors in both the ho st and the pathoge n. For instance, ho st genetic polymorphisms in proinflammato r y c yto kine gene s affect the risk of gastr ic ca rcinoma. 3 , 4 Gene t ic diver sit y i n H. pylori strains also plays a crucial role in gastric cancer develop ment.…”

Gastric Precancerous Lesions in First Degree Relatives of Patients with Known Gastric Cancer: a Cross-Sectional Prospective Study in Guilan Province, North of Iran

“…Previous studies have shown that individuals infected with compared to non-infected individuals have more than twice as much risk of developing gastric cancer (Huang et al,1998;Motta et al, 2008;Lee eta l., 2012). Uemura et al (2001) found that all of the patients with gastric cancer had infection in the past. In our study, the prevalence of infection among cancer patients` relatives was difference; maybe due to the high prevalence of infection in Iranian society (Brenner et al, 2000;El-Omar et al, 2000;Malekzadeh et al, 2001).…”

“…The relatives of gastric cancer patients were found to have a three-fold increased risk of developing gastric carcinoma (Zhang et al, 2005;Kang et al, 2011). Upper GI endoscopy and biopsy for diagnosis of precancerous lesion is relatively accounted as an appropriate method (Uemura et al, 2001;Dinis-Ribeiro etal., 2012). Our results confirmed that precancerous lesions such as higher in gastric cancer relatives rather than control group.…”

Dispepsia: caracterização e abordagem

“…), difi cilmente a porcentagem de pacientes com dispepsia não diagnosticada é maior que 5%, quando submetida ao exame endoscópico 32 .…”