H. pylori and risk of ulcer bleeding among users of NSAIDs

Helicobacter pylori infection is a protective factor for bleeding gastric ulcers but not for bleeding duodenal ulcers in NSAID users

“…We think that our study cannot be compared since the approach is very different. The study reported by Aalykke et al 4,5 included current users of NSAID admitted because of bleeding peptic ulcer as patients and NSAID users without gastrointestinal complications as controls; in our report we studied the entire population, which allow the inclusion of interaction terms between these two factors. Other studies with a similar design have also concluded that the presence of H. pylori and NSAID use does not increase the risk of ulcer bleeding.…”

Reply —Helicobacter pylori infection is a protective factor for bleeding gastric ulcers but not for bleeding duodenal ulcers in NSAID users

“…The study reported by Aalykke et al 4 , . 5 included current users of NSAID admitted because of bleeding peptic ulcer as patients and NSAID users without gastrointestinal complications as controls; in our report we studied the entire population, which allow the inclusion of interaction terms between these two factors. Other studies with a similar design have also concluded that the presence of H. pylori and NSAID use does not increase the risk of ulcer bleeding 2 ,.…”