H�mangio-endoth�lio-sarcome spl�nique avec �rythrophagocytose et angiopathie thrombotique

Primary malignant fibrous histiocytoma of the spleen: an ultrastructural study

“…In the past this tumour has often been confused with other sarcomas, including a fibrosarcoma, leiomyosarcoma, liposarcoma, rhabdoniyosarcoma. In the spleen primary malignant tumours are rare and most of these are lymphoid neoplasms (Das Gupta, Coombes & Brasfield 1965) but angiosarcoma, fibrosarcoma and leiomyosarcoma have also been observed (Bostick 1945, Rappaport 1966, Hopfner et al 1972. In our case the histological mixture of spindle cells arranged in a s t xiform pattern, polygonal histiocyte-like elements, giant cells, and foam cells was typical of MFH and the ultrastructural analysis was similar to that observed by other authors (Fu et…”

Malignant haemangioendothelioma involving the liver

“…Microangiopathic haemolytic anaemia complicates various disease states, including carcinomatosis, and has been described in several adults with haemangioendotheliomas of the liver (Alpert and Benisch, 1970;Donald and Dawson, 1971;Hopfner Dufour, Pluot et al, 1972). Two of our four cases had evidence of a haemolytic anaemia, and the distorted and fragmented red cells in the blood films suggested that the haemolysis was related to a microangiopathic process.…”

Disseminated angiosarcoma presenting as a hemophagocytic syndrome in a renal allograft recipient

“…In these cases, the tumor occurs preferentially at sites of prior surgery [l], altered vasculature [4, 5, 8, 131, or irradiation [12] ( Table 1). This tumor may show prominent erythrophagocytic activity [6,11] and may be responsible for miscellaneous coagulation disorders [3,6,7,11]. However, hemophagocytic syndrome encompasses a group of clinicopathological findings especially characterized by fever, pancytopenia, hypertriglyceridemia, hypofibrinogenemia, and a systemic proliferation of histiocytes showing hemophagocytosis [HI.…”