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Peterson, Leif E.; Lau, Kwong

doi:10.1186/gb-2002-3-7-preprint0005

Cited by 6 publications

(1 citation statement)

References 29 publications

(35 reference statements)

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“…Intermittency defines the basic natural properties of DNA activity inside cells [3,16]. Intermittency in DNA chips was observed in [17].…”

Section: Intermittency For Chromosomal Associations Of Information Comentioning

confidence: 99%

How chromosomal correlations form a single information complex DNA inside living cells? Intermittency informational connections DNA

Galich¹

2015

ams

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Are analyzed experimental data on fluorescence DNA complexes inside neutrophils and other cells in flow cytometry experiments with nanometer spatial resolution in the large populations of cells. It is shown that DNA information is packed in ultra dense fractal networks of 'exponentially small worlds'. The exponential growth of high order's central moments for fluctuations information in DNA fluorescence characterizes existence of intermittency in joint information complexes DNA inside living cell. Intermittency selects and ensures dominating role of corresponding correlations in DNA information. Intermittency depends on the correlation scales and order of chromosomal correlations (cooperative links). Intermittency of DNA information occurs in the coalitions of chromosomes and exists if number of correlated DNA is not small and more than one, two or three; this is the collective effect. Intermittency is observed for different, rather high orders of multiple chromosomal correlations and depends on a personal health status in given time. Strong or weak level of intermittency in information activity of correlated chromosomes also depends on the health conditions. All these facts reflect various distributions of high order's central moments for fluctuations in DNA information; oscillations, growth, decrease, switching of various functions at changes the scale, number or order of chromosomal correlations. Intermittency defines the basic natural properties of DNA activity inside cells and DNA chips.

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“…Intermittency defines the basic natural properties of DNA activity inside cells [3,16]. Intermittency in DNA chips was observed in [17].…”

Section: Intermittency For Chromosomal Associations Of Information Comentioning

confidence: 99%

How chromosomal correlations form a single information complex DNA inside living cells? Intermittency informational connections DNA

Galich¹

2015

ams

View full text Add to dashboard Cite

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A gene expression analysis system for medical diagnosis

Maroulis¹,

Iakovidis²,

Flaounas³

et al.

IFIP International Federation for Information Processing

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In this paper we present a novel system that utilizes molecular-level information for medical diagnosis. It accepts high dimensional vectors of gene expressions, quantified by means of microarray image analysis, as input. The proposed system incorporates various data pre-processing methods, such as missing values estimation and data normalization. A novel approach to the classification of gene expression vectors in multiple classes that embodies various gene selection methods has been adopted for diagnostic purposes. The proposed system has been extensively tested on various, publicly available data-sets. We demonstrate its performance for prostate cancer diagnosis and compare its performance with a well established multiclass classification scheme. The results show that the proposed system could be proved a valuable diagnostic aid in medicine.

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Identification of Prognosis Markers in Pediatric High-Risk Acute Lymphoblastic Leukemia

Al-Lamki¹,

Wali²,

Wasifuddin³

et al. 2005

Pediatric Hematology and Oncology

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Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

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Untitled

Cited by 6 publications

References 29 publications

How chromosomal correlations form a single information complex DNA inside living cells? Intermittency informational connections DNA

How chromosomal correlations form a single information complex DNA inside living cells? Intermittency informational connections DNA

A gene expression analysis system for medical diagnosis

Identification of Prognosis Markers in Pediatric High-Risk Acute Lymphoblastic Leukemia

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