Gynecology Relevant to Andrology

Knuth, Ulrich A.

doi:10.1007/978-3-540-78355-8_20

Cited by 1 publication

(5 citation statements)

References 128 publications

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“…The observed inverse association between endogenous estradiol and LTL, coupled with prior evidence that Danazol has hypoestrogenic effects in women (Hoffman, 2016; Knuth, 2010), suggests a Danazol-induced hypoestrogenic state may underlie the observed association between Danazol treatment and increased LTL. Thus, further investigation of sex steroid hormones should be considered to further elucidate the mechanisms underlying the association between Danazol and LTL.…”

Section: Discussionmentioning

confidence: 67%

“…Overall, the findings from this analysis and similar previous studies demonstrate the complex and equivocal role of sex steroid hormones in the association between danazol and LTL, as well as the need for further longitudinal research. The observed inverse association between endogenous estradiol and LTL, coupled with prior evidence that danazol has hypoestrogenic effects in women (Knuth, 2010;Hoffman, 2016), suggests a danazol-induced hypoestrogenic state may underlie the observed association between danazol treatment and increased LTL. Thus, further investigation of sex steroid hormones should be considered to further elucidate the mechanisms underlying the association between danazol and LTL.…”

Section: Discussionmentioning

confidence: 72%

“…The inconsistent results from studies of endogenous sex steroid hormones (specifically estradiol) and telomere length highlight the complexity of these relationships and mirror the intricate pharmacology of Danazol, which has been described as a weak androgen, weak functional anti-estrogen, weak anti-gonadotropin, weak progestogen, competitive inhibitor of SHBG, and a down regulator of SHBG (Hoffman, 2016; Knuth, 2010). Although the authors exploring Danazol and LTL hypothesized that an estrogen response element (ERE) in the TERT promoter may underlie the observed positive association between Danazol and telomere length (Townsley et al, 2016), there is evidence that Danazol does not bind to the estrogen receptor (Knuth, 2010) and the ERE has high specificity for the estrogen receptor.…”

Section: Discussionmentioning

confidence: 99%

“…Although the authors exploring Danazol and LTL hypothesized that an estrogen response element (ERE) in the TERT promoter may underlie the observed positive association between Danazol and telomere length (Townsley et al, 2016), there is evidence that Danazol does not bind to the estrogen receptor (Knuth, 2010) and the ERE has high specificity for the estrogen receptor.…”

Section: Discussionmentioning

confidence: 99%

“…Further, preliminary evidence has demonstrated that sex steroid hormones may increase telomerase activity in certain cell lines and tissue types (Calado et al, 2009; Kyo et al, 1999; Nanni et al, 2002; Nourbakhsh et al, 2010; Sato et al, 2004). A recent phase 1–2 clinical trial provided evidence that oral Danazol—a synthetic steroid sex hormone with weak androgenic effects and functional anti-estrogenic effects (Hoffman, 2016; Knuth, 2010)—led to leukocyte telomere elongation in individuals with telomeropathies (Townsley et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

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Associations between circulating sex steroid hormones and leukocyte telomere length in men in the National Health and Nutrition Examination Survey

et al. 2018

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Preliminary evidence suggests that sex steroid hormones, such as danazol (a synthetic sex steroid hormone), may be involved in enhancing telomerase activity. Elucidating underlying mechanisms of telomerase activity may further therapeutic options for individuals with telomeropathies and potentially avert certain age-related conditions. Therefore, we conducted a cross-sectional study to investigate the relationship between circulating sex steroid hormones and SHBG with leukocyte telomere length among 499 males in NHANES (1999-2002 surveys). Sample-weighted linear regression analyses were conducted to assess age-adjusted and multivariable-adjusted estimates of associations. Estimates were rescaled to represent telomere length change in base pairs per half the value of the interquartile range of the independent variable. Estradiol and free estradiol were significantly inversely associated with leukocyte telomere length (β = -61, p = 0.04; free estradiol β = -67, p = 0.03). Testosterone, free testosterone, androstanediol glucuronide, and SHBG were not associated with leukocyte telomere length. The inverse association seen in this study indicates that a danazol-induced hypoestrogenic state could partly underlie the previously observed association between danazol therapy and increased leukocyte telomere length.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 72%