Gynecological history up to diagnosis and pregnancy outcomes in diagnosed Wilson's disease under therapy � a bicentric matched control cohort study

Roseira, Joana; Lopes, Rita de Cássia Sobreira; Silva, Mário Jorge; Vieira, Ana Cristina; Sampaio, Margarida; Calinas, Filipe

doi:10.17235/reed.2020.7444/2020

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…[18][19][20] Miscarriage rates for patients with WD may be higher than the general population. 80,81 However, while one study found this occurred despite zinc or DPA therapy, 80 another found the relative risk to be significantly lower with these drugs. 81 Offspring may be more likely to have a low birth weight, with no difference according to therapy type.…”

Section: Reproduction In People With Wilson's Diseasementioning

confidence: 99%

“…81 Offspring may be more likely to have a low birth weight, with no difference according to therapy type. 80 The EMA, and some guidance documents, advise against breastfeeding while receiving zinc therapy due to potential zinc-induced CD in the infant. 17,20,31 However, while zinc levels may increase in breastmilk when taking this therapy, this was apparently without consequences in one study, leading the authors to conclude that breastfeeding while taking zinc was safe.…”

Section: Reproduction In People With Wilson's Diseasementioning

confidence: 99%

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Zinc for Wilson’s Disease: What We Know and What We Don’t Know

Di Dato,

Hedera

2024

EMJ

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Section: Reproduction In People With Wilson's Diseasementioning

confidence: 99%

Section: Reproduction In People With Wilson's Diseasementioning

confidence: 99%

Zinc for Wilson’s Disease: What We Know and What We Don’t Know

Di Dato,

Hedera

2024

EMJ

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“…A limited number of retrospective studies and case/series reports [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] have evaluated maternal and newborn outcomes in WD, and here, we aimed to analyze these studies to provide a more comprehensive overview.…”

Section: Introductionmentioning

confidence: 99%

The Maternal and Fetal Outcomes of Pregnancy in Wilson’s Disease: A Systematic Literature Review and Meta-Analysis

et al. 2022

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Wilson’s disease (WD) is a rare, treatable genetic disorder with multi-organ symptoms related mainly to copper accumulation. Most patients become aware of the disease as young adults, thus knowledge on fertility, pregnancy course and outcome is very important both for patients and physicians. The aim of this study was to perform a systematic review and meta-analysis of pregnancy outcomes in women with WD. This systematic literature review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies were identified by searching the PubMed database (up to 12 January 2022) and by screening reference lists. We found 49 publications, including 13 retrospective studies and 36 series and case reports on pregnancy outcomes in WD patients. In total, descriptions of 449 pregnant women with 822 pregnancies were retrieved. Successful deliveries were achieved in 78.3% (644/822) of all pregnancies. Spontaneous abortions were observed in 21.7% (178/822) of pregnancies, more frequently in patients who were untreated 68.6% (96/140). Analyzing maternal outcome, 2.2% (18/822) of pregnancies were associated with the aggravation of neurological symptoms. Symptoms of hepatic deterioration were observed in 4.6% (38/822) of cases. These were usually transient and recovered after pregnancy; however, death due to liver failure was observed in 0.2% (2/822) of cases. Birth defects occurred in 4.7% (39/822) of pregnancies. The available meta-analysis showed statistically significant positive associations between anti-copper treatment and pregnancy outcome. Our results document the significance of anti-copper treatment as the main factor leading to successful pregnancy, as well as positive outcomes for women with WD.

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Zinc for Wilson’s Disease: What We Know and What We Don’t Know

Di Dato,

Hedera

2024

EMJ

View full text Add to dashboard Cite

Gynecological history up to diagnosis and pregnancy outcomes in diagnosed Wilson's disease under therapy � a bicentric matched control cohort study

Cited by 4 publications

References 26 publications

Zinc for Wilson’s Disease: What We Know and What We Don’t Know

Zinc for Wilson’s Disease: What We Know and What We Don’t Know

The Maternal and Fetal Outcomes of Pregnancy in Wilson’s Disease: A Systematic Literature Review and Meta-Analysis

Zinc for Wilson’s Disease: What We Know and What We Don’t Know

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