Gynecologic Cytology

Krishnamurti, Uma; Mošunjac, Marina; Deftereos, Georgios; Hanley, Krisztina

doi:10.1007/978-981-13-3019-3_17

Cited by 1 publication

(1 citation statement)

References 218 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The American Cancer Society estimated that 12820 cases of invasive cervical cancer are diagnosed in the United States each year. Approximately 79 million Americans were infected with HPV[ 6 ]. Ermel et al [ 2 ] observed that pathogenic HPV was detected in many women.…”

Section: Discussionmentioning

confidence: 99%

Follow-up study on ThinPrep cytology test-positive patients in tropical regions

Chen¹,

Liang²,

Wang³

et al. 2022

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND As shown in the statistics from the World Health Organization, it is estimated that approximately 75000 new cases of cervical cancer occur every year in China. In 2008, 33000 people died of cervical cancer in China. It is proven that most women are at risk of cervical cancer. The progression from human papillomavirus (HPV) infection to cervical cancer can be several years or decades, which offers a unique opportunity to prevent cancer. AIM To observe the changes in ThinPrep cytology tests (TCT) and HPV infection in patients who were detected to be positive via TCT screening of cervical cancer and further explore the biopsy results. METHODS This paper performed a follow-up study on 206 cervical cancer screening-positive patients of 12231 total cases from our previous research. We conducted an observational study on the TCT results based on the interpretation of The Bethesda System. RESULTS Over a 5-year period, 10 cases received consistent follow-up. The proportions of cases in which glandular epithelial lesions were detected increased over the follow-up period. The differences between the years were statistically significant ( P < 0.01). Over the 5 years, the proportion of patients whose squamous epithelial lesions transformed into glandular epithelial lesions increased yearly. Annual positive rates of HPV infection were: year 1, 73% (24/33); year 2, 43% (6/14); year 3, 36% (9/25); year 4, 50% (9/18); and year 5, 25% (6/24). The positive detection rate after biopsy over a 9-year period was 29%. CONCLUSION The follow-up study for 5 years to 9 years revealed a tendency to change from squamous epithelial lesions to glandular epithelial lesions and an improvement of the disease (which had not been reported previously). The HPV test indicated a high negative conversion ratio of the viral infection. However, the follow-up cases were not found to have persistent infection of high-risk HPV. Therefore, early intervention of cervical cancer screening is necessary. Low re-examination compliance, patient education, and preventive measures should be enhanced.

show abstract

Section: Discussionmentioning

confidence: 99%