Gynecologic cancer screening in the transgender male population and its current challenges

Patel, Jharna M.; Dolitsky, Shelley; Bachman, George; Meritens, Alexandre Buckley de

doi:10.1016/j.maturitas.2019.08.009

Cited by 20 publications

(12 citation statements)

References 33 publications

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“…Nesse aspecto, parte dos estudos utilizados apon tou que uma parcela significativa da população alvo não realiza o rastreamento do câncer de colo de útero na periodicidade preconizada, sendo este inferior quando comparado aos números da população cisgênero feminina (KIRAN et al, 2019;PATEL et al, 2019;SEAY et al, 2017). Outros estudos revelam também que há um déficit na relação entre os usuários trans e os profissionais de saúde, o que resulta na manutenção do estigma e baixa adesão aos serviços de saúde (NISLY et al, 2018;POTTER et al, 2015).…”

Section: Resultsunclassified

Adesão Ao Rastreamento Do Câncer De Colo De Útero Na População Trans

Mota

Andrade

Gallotti³

et al. 2021

Rev. Bras. Sex. Hum.

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O câncer do colo do útero é um dos mais comuns entre aqueles que apresentam o aparelho reprodutor feminino. No entanto, é prevenível e tratável, mas há uma dificuldade de captação do público alvo bem como baixa adesão ao rastreamento na periodicidade adequada mesmo na população feminina cisgênero, sendo esta dificuldade acentuada entre os transexuais. Por isso, este artigo objetivou analisar a realidade da população transexual, em especial dos homens trans, buscando identificar as experiências, dificuldades e necessidades destes quanto à adesão ao exame citopatológico para rastreamento do câncer de colo de útero na Atenção Primária através de uma revisão integrativa com busca realizada em três bases de dados: Scopus, ScienceDirect e PubMed, sendo obtida uma amostra de 8 artigos para a composição deste estudo. Os resultados mostraram que os usuários trans procuram bem menos o serviço de saúde quando comparado ao público heterossexual/cisgênero, tanto pela abordagem, manejo e falta da relação paciente-profissional durante a consulta e exame quanto pelo desconforto e disforia de gênero, levando assim à baixa adesão ao serviço de saúde. Alguns artigos trazem ainda, em conseguinte a este ponto, a preferência de alguns usuários pela auto-coleta.

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Section: Resultsunclassified

Adesão Ao Rastreamento Do Câncer De Colo De Útero Na População Trans

Mota

Andrade

Gallotti³

et al. 2021

Rev. Bras. Sex. Hum.

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“…Except for health disparities research in sexually transmitted infection risk and management (including HIV), limited research addresses the specific reproductive and sexual health needs of LGBTQ+ older adults (Marshall & Cahill, 2021). Examples include (a) contraceptive method access and preferences (Lampe, 2022b;Lampe and Nowakowski, 2021); (b) breast/chest cancer risk among transgender patients receiving hormone therapy services (de Blok et al, 2019); (c) prostate cancer risk among some gay, bisexual, and queer (GBQ+) men, transgender women, and non-binary people (Rosser et al, 2016); (d) cervical, endometrial, and uterine cancer risk among some LBQ+ women, transgender men, and non-binary people (Patel et al, 2019); and (e) rectal and anal cancer risk among some GBTQ+ men and transgender women (Ceres et al, 2018). Further examination of these research areas can help inform clinical research and practice to improve the reproductive and sexual health of LGBTQ+ older populations.…”

Section: Reproductive and Sexual Health Disparitiesmentioning

confidence: 99%

Health Disparities Among Lesbian, Gay, Bisexual, Transgender, and Queer Older Adults: A Structural Competency Approach

Lampe

Barbee

Tran

et al. 2023

Int J Aging Hum Dev

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Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) older adults experience significant health disparities. Examining these disparities has become an international research priority, but gaps remain. In this review article, we summarize major contributions of and ongoing gaps in health disparities research among LGBTQ+ older adults, while focusing on four major content areas: (a) social determinants of health disparities, (b) mental, cognitive, and physical health disparities, (c) reproductive and sexual health disparities, and (d) seeking LGBTQ+-affirming and age-friendly care. Using a structural competency approach, we develop a four-part agenda for this research area that enhances our understanding of how macro-level systems, institutions, and structures drive health disparities among aging LGBTQ+ communities. We also outline future research on structural competency in LGBTQ+ older adult health, while providing recommendations for researchers and clinicians. These recommendations illuminate potential best practices for bettering the health and quality of life of LGBTQ+ older populations.

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“…In these patients the ovaries, the uterus and the breasts are surgically removed and masculinization is achieved by treatment with high doses of testosterone (HDT). The occurrence of BC in FtM transgenders depends on the completeness of removing all mammary tissue by mastectomy [ 70 , 72 , 74 ] and is comparable to the prevention of BC by mastectomy in high-risk women carrying germline mutations such as BRCA1 and BRCA2 [ 75 ]. In the Dutch cohort study, four cases of BC were reported in 1,229 FtM individuals treated with HDT with a SIR vs Dutch cisgender women of 0.2 (95% CI 0.1‒0.5) [ 73 ].…”

Section: Pharmaceutical Effectsmentioning

confidence: 99%

Progesterone from ovulatory menstrual cycles is an important cause of breast cancer

et al. 2023

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Many factors, including reproductive hormones, have been linked to a woman’s risk of developing breast cancer (BC). We reviewed the literature regarding the relationship between ovulatory menstrual cycles (MCs) and BC risk. Physiological variations in the frequency of MCs and interference with MCs through genetic variations, pathological conditions and or pharmaceutical interventions revealed a strong link between BC risk and the lifetime number of MCs. A substantial reduction in BC risk is observed in situations without MCs. In genetic or transgender situations with normal female breasts and estrogens, but no progesterone (P4), the incidence of BC is very low, suggesting an essential role of P4. During the MC, P4 has a strong proliferative effect on normal breast epithelium, whereas estradiol (E2) has only a minimal effect. The origin of BC has been strongly linked to proliferation associated DNA replication errors, and the repeated stimulation of the breast epithelium by P4 with each MC is likely to impact the epithelial mutational burden. Long-lived cells, such as stem cells, present in the breast epithelium, can carry mutations forward for an extended period of time, and studies show that breast tumors tend to take decades to develop before detection. We therefore postulate that P4 is an important factor in a woman’s lifetime risk of developing BC, and that breast tumors arising during hormonal contraception or after menopause, with or without menopausal hormone therapy, are the consequence of the outgrowth of pre-existing neoplastic lesions, eventually stimulated by estrogens and some progestins.

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Gynecologic cancer screening in the transgender male population and its current challenges

Cited by 20 publications

References 33 publications

Adesão Ao Rastreamento Do Câncer De Colo De Útero Na População Trans

Adesão Ao Rastreamento Do Câncer De Colo De Útero Na População Trans

Health Disparities Among Lesbian, Gay, Bisexual, Transgender, and Queer Older Adults: A Structural Competency Approach

Progesterone from ovulatory menstrual cycles is an important cause of breast cancer

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