Gynecologic and andrologic dermatology and the metabolic syndrome

Roth, Maria Magdalena; Leader, Nicholas; Kroumpouzos, George

doi:10.1016/j.clindermatol.2017.09.013

Cited by 16 publications

(22 citation statements)

References 128 publications

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“…The prevalence of MetS in children is unknown because of a lack of diagnostic criteria in the pediatric population (Hadjiyannakis, 2005, Weiss et al, 2013). Factors such as obesity, IR, genetic predisposition, environment, and ethnic heritage may be involved in MetS development during childhood (Roth et al, 2018). Early menarche, especially among low-birth-weight females, increases the risk of MetS during young adulthood (Kim and Je, 2019, Lim et al, 2016, Vryonidou et al, 2015).…”

Section: Metabolic Syndrome Through Female Life Cyclementioning

confidence: 99%

“…These mechanisms are involved in complex interactions; for example, the chronic inflammation that is often linked to obesity makes IR more likely to occur. Sex hormones have complex interactions with obesity, inflammation, and MetS (Roth et al, 2018). IR, possibly related to a postreceptor defect in adipose tissue, plays a paramount role in MetS.…”

Section: Mechanisms Underlying the Skin: Metabolic Syndrome Connectionmentioning

confidence: 99%

“…Conditions associated with hyperandrogenism are shown in Table 2 (Carmina et al, 2006a, Carmina et al, 2006b, Keen et al, 2017, Meek et al, 2013, Mihailidis et al, 2015, Roth et al, 2018, Schmidt and Shinkai, 2015). Acne is the most common manifestation of cutaneous hyperandrogenism (Clark et al, 2014).…”

Section: Mechanisms Underlying the Skin: Metabolic Syndrome Connectionmentioning

confidence: 99%

“…Acne is the most common manifestation of cutaneous hyperandrogenism (Clark et al, 2014). Other cutaneous manifestations include hirsutism, acanthosis nigricans (AN), female pattern alopecia (PA), and skin tags (STs) (Clark et al, 2014, Roth et al, 2018). The clinical assessment of hyperandrogenism should be followed by a biochemical assessment (Meet et al, 2013).…”

Section: Mechanisms Underlying the Skin: Metabolic Syndrome Connectionmentioning

confidence: 99%

“…Any pathophysiologic dysfunction, such as insulin resistance (IR), that results in metabolic alterations can also result in cutaneous disease (Stefanadi et al, 2018, Wu et al, 2012). A body of literature has demonstrated that sex hormones are linked to pathways of MetS (Ahmed et al, 2017, Kroumpouzos, 2013, Laaksonen et al, 2004, Roth et al, 2018). Obesity induces chronic inflammation associated with MetS, and the bidirectional relationship of sex hormones with obesity has been validated in several studies (Brown et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Skin disease related to metabolic syndrome in women

Misitzis

Cunha

Kroumpouzos

2019

International Journal of Women's Dermatology

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Sex hormones are involved in pathways of metabolic syndrome (MetS), an observation supported by animal studies. The relationships of sex hormones with components of MetS, such as insulin resistance and dyslipidemia, have been studied in pre- and postmenopausal women. High testosterone, low sex hormone-binding globulin, and low estrogen levels increase the risks of MetS and type 2 diabetes in women. Cutaneous diseases that are sex hormone mediated, such as polycystic ovary syndrome, acanthosis nigricans, acne vulgaris, and pattern alopecia, have been associated with insulin resistance and increased risk for MetS. Furthermore, inflammatory skin conditions, such as hidradenitis suppurativa and psoriasis, increase the risk for MetS. Patients with such skin conditions should be followed for metabolic complications, and early lifestyle interventions toward these populations may be warranted.

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Section: Metabolic Syndrome Through Female Life Cyclementioning

confidence: 99%

Section: Mechanisms Underlying the Skin: Metabolic Syndrome Connectionmentioning

confidence: 99%

Section: Mechanisms Underlying the Skin: Metabolic Syndrome Connectionmentioning

confidence: 99%

Section: Mechanisms Underlying the Skin: Metabolic Syndrome Connectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Skin disease related to metabolic syndrome in women

Misitzis

Cunha

Kroumpouzos

2019

International Journal of Women's Dermatology

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The Skin and Endocrine Disorders

Paus,

Ramot

2024

Rook's Textbook of Dermatology

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Endocrine disorders can exert major effects on the human skin, leading to different signs and symptoms, including skin dryness, hair loss or excessive hair growth, pruritus, pigmentary changes and hyperhidrosis. This chapter reviews these changes and provides a practical approach to patients with suspected underlying endocrinological disorders. The chapter also discusses the latest findings showing that the skin serves as a complex (neuro‐) endocrine organ by itself, and thus possesses important practical implications for future dermatological therapy.

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Pituitary Effects of Metformin in Men With Early‐Onset Androgenic Alopecia

Krysiak

Kowalcze

2022

The Journal of Clinical Pharma

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Males with early-onset androgenic alopecia are characterized by elevated androgen levels. The aim of the present study was to investigate whether the presence of this condition modulates the impact of metformin on pituitary hormone production. This study compared 2 groups of young men with prediabetes, matched for age, blood pressure, and insulin sensitivity: 23 subjects with early-onset male-pattern baldness (group 1) and 25 individuals with normal hair growth (group 2). Throughout the study, both groups were treated with metformin for 6 months. Circulating levels of glucose, insulin, glycated hemoglobin, gonadotropins, thyrotropin, prolactin, adrenocorticotropic hormone, insulin-like growth factor-1 and androgens were determined at the beginning of the study and 6 months later. At entry, luteinizing hormone (LH), the LH/follicle-stimulating hormone ratio, total testosterone, bioavailable testosterone, adrenocorticotropic hormone and dehydroepiandrosterone sulfate were higher in group 1 than in group 2. The effect of metformin on fasting glucose, insulin sensitivity, and glycated hemoglobin was more pronounced in group 2 than in group 1. Only in group 1, metformin reduced LH levels and the LH/follicle-stimulating hormone ratio. Metformin did not affect plasma levels of the remaining hormones. In untreated men with androgenic alopecia (group 3, n = 22), glucose homeostasis markers and hormone levels remained similar throughout the study period. The obtained results suggest that the impact of metformin on gonadotroph secretory function is stronger in men with early-onset androgenic alopecia than in men with normal hair growth. Metformin treatment may protect men with early-onset androgenic alopecia against the development of gonadotroph hyperplasia and/or focal testicular changes.

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Gynecologic and andrologic dermatology and the metabolic syndrome

Cited by 16 publications

References 128 publications

Skin disease related to metabolic syndrome in women

Skin disease related to metabolic syndrome in women

The Skin and Endocrine Disorders

Pituitary Effects of Metformin in Men With Early‐Onset Androgenic Alopecia

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