Gynaecomastia as a paraneoplastic syndrome secondary to hCG secreting lung cancer

James, Cornelius Fernandez; Aarella, Vikram

doi:10.1530/endoabs.69.p33

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High titer of HCG causes hyperthyroidism due to cross-reaction with thyrotropin stimulating hormone (TSH) [ 18 ] which could be related to our patient hyperthyroidism state. Moreover, the rising HCG, as LH analogue, plays as the main stimuli for Leydig cells to secrete more estrogen and less testosterone justifying the gynecomastia [ 19 ] and atrophic testis in present case. Almost 1% of testicular cancer patients present by Gynecomastia [ 20 ].…”

Section: Discussionmentioning

confidence: 98%

“…In one hand, One of most common clinical features of pure choriocarcinoma which associated with hemorrhage at metastatic sites is high level of serum (βHCG) [ 17 ] known as choriocarcinoma syndrome characterized by haemopstysis, dyspnea, hematemesis, melena and anemia [ 9 ]. On the other hand, high level of βHCG causes paraneoplastic syndromes such as hypothyroidism [ 18 ], and Gynecomastia [ 19 ]. High titer of HCG causes hyperthyroidism due to cross-reaction with thyrotropin stimulating hormone (TSH) [ 18 ] which could be related to our patient hyperthyroidism state.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pure testicular choriocarcinoma with gastrointestinal metastasis and paraneoplastic symptoms: a case report

et al. 2023

View full text Add to dashboard Cite

Background Pure testicular choriocarcinoma is a rare type of non-seminomatous germ cell tumor extremely poor prognostic with the tendency to bleed at the metastatic site. At the time of the diagnosis, 70% of patients have metastatic lesions. Depending on the site of the metastasis, symptoms vary. Gastrointestinal involvement is seen in less than 5% of cases, mostly in the duodenum. Case presentation We present a 47 years old male with testicular choriocarcinoma involving the jejunum, lung, liver, and kidney presenting with acute abdominal pain, melena, and dyspnea with some paraneoplastic symptoms. The patient had increased, severe and constant pain in the right lower quadrant for the previous four days. Additionally, he was complaining of nausea, vomiting, anorexia, and a history of melena for the last 10 days. Dyspnea on exertion, hemoptysis, and dry cough were the symptoms he was suffering from, for almost one year. The patient’s general appearance was pale, ill, and thin with 10 kg of weight loss during the last some months. The computed tomography (CT) scan reported multiple metastatic lesions in both liver lobes and the left kidney. Pathologic study of the samples of small bowel lesions showed metastatic choriocarcinoma. Following the patient had been referred to an oncologist to start the chemotherapy regime. Finally, the patient has expired after 40 days of his first admission. Conclusions Testicular choriocarcinoma is a rare but fatal malignancy among young men. Gastrointestinal metastases are infrequent involvement represented by melena and acute abdominal pain, obstruction, and mass. Physicians should consider it as a differential diagnosis for acute abdomen and gastrointestinal bleeding causation.

show abstract

Section: Discussionmentioning

confidence: 98%