GW25-e5365 Bone Marrow stem cells: Immune property genes assay and effect of transplantation on the immune cells of heart failure patients

Zhang, Ningkun; Lian-ru, Gao; Li, Tianchang; Zhu, Zhiming; Tian, Hui; Wang, Zhiguo; Chen, Yu

doi:10.1016/j.jacc.2014.06.223

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“…Whether, and how, BMSCs play a key role in the anti-inflammation and immunoregulation in a model of POF is still unclear. However, BMSCs play an important role in anti-inflammation and immunoregulation for other diseases, such as heart failure [ 40 ], sepsis [ 41 ], and allergic rhinitis [ 42 ]. A study suggests that BMSC paracrine activity has an anti-inflammatory effect and an antiapoptotic effect on intervertebral disc degeneration (IDD) and that this is mediated, at least in part, via the relative nuclear factor-κB (NF-κB) and mitochondrial apoptotic pathways in annulus fibrosus (AF) cells [ 43 ].…”

Section: Anti-inflammatory Effects and Immunoregulatory Effects Of Bmmentioning

confidence: 99%

The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure

et al. 2018

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With the development of regenerative medicine, a variety of mesenchymal stem cells (MSCs) are increasingly considered for the treatment of premature ovarian failure (POF). Reportedly, bone marrow-derived MSCs (BMSCs) improve the ovarian reserve, which mainly depends on homing and paracrine activities. Furthermore, paracrine factors secreted by these stem cells play an important role in ovarian recovery. Relevant studies indicate that BMSC transplantation has some positive effects on the treatment of POF in animals, but BMSCs are not widely applied in clinical therapy. Clinical trials are ongoing despite the fact that several patients experiencing BMSC transplantation recover their normal menstrual cycles and even give birth to babies. In this review, we discuss the possible therapeutic mechanisms of BMSCs for POF, migration, antiapoptosis, antifibrosis, angiogenesis, anti-inflammation, immunoregulation, and oxidative stress, which provide the theoretical basis for further study and clinical therapy.

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Section: Anti-inflammatory Effects and Immunoregulatory Effects Of Bmmentioning

confidence: 99%

The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure

et al. 2018

View full text Add to dashboard Cite

show abstract

GW25-e5365 Bone Marrow stem cells: Immune property genes assay and effect of transplantation on the immune cells of heart failure patients

Cited by 1 publication

References 0 publications

The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure

The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure

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