GW24-e3986 Aspirin given twice daily reduced the platelet reactivity more than once daily in people with type 2 diabetes without cardiovascular disease
Abstract:Objectives
In type 2 diabetes (T2DM), low dose Aspirin has been established for secondary cardiovascular prevention, but as yet there is no definitive data showing primary cardiovascular prevention. We hypothesized that a double dose of ASA would further reduce platelet reactivity and, given the increased platelet turnover, may be most effective when given in divided doses twice-daily.
Methods
This 3-period, 3-treatment, crossover study randomized 24 adults (51 ± 7 years old, BMI 31.4 ± 7.2 kg/m2, HbA1c 47 ±… Show more
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