Guttate Leukoderma in Darier's Disease

Cornelison, Raymond L.; Smith, Edgar B.; Knox, John M.

doi:10.1001/archderm.1970.04000100095020

Cited by 19 publications

(10 citation statements)

References 7 publications

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“…Although Darier's disease was originally described in 1889, this variant characterized by hypopigmented macules in dark‐skinned individuals was first recognized by Goodall and Richmond in 1965 1 . These hypopigmented macules are present in a perifollicular distribution on the neck, trunk, arms, and thighs and have been described as guttate leukoderma in Darier's disease 2 . Originally regarded as postinflammatory hypopigmentation, these lesions were later recognized as an early or subclinical form of this acantholytic disorder 3,4 …”

Section: Discussionmentioning

confidence: 99%

A unique variant of Darier's disease

Peterson¹,

Lesher²,

Sangüeza³

2001

Int J Dermatology

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A 45-year-old black woman presented with a chief complaint of an increasing number of "light spots" on her face, upper trunk, and legs. She had a 4-year history of a pruritic eruption on the dorsum of her hands. The eruption was particularly pruritic in the summer months. Other family members, including her sister and her daughters, reportedly had a similar dermatologic problem. The patient had been previously evaluated and biopsied by another dermatologist. The earlier biopsy was nondiagnostic, however, and she presented for further evaluation of this problem. On physical examination, the patient had hypopigmented macules along her jawline (Fig. 1), lateral neck, and upper chest. She had similar hypopigmented macules on her thighs. She had hyperkeratosis of the palmoplantar surface of her hands and feet. The dorsum of her hands had numerous coalescing, shiny, flat-topped, hypopigmented papules (Fig. 2), and several of her fingernails had distal, V-shaped notching. A punch biopsy from a papule on the dorsum of her hand was obtained. The epidermis had corps ronds present with focal areas of acantholysis above the basal layer (Fig. 3). The dermis had sparse, superficial, perivascular infiltrates composed of lymphocytes and histiocytes. These changes were consistent with our clinical diagnosis of Darier's disease (keratosis follicularis).

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Section: Discussionmentioning

confidence: 99%

A unique variant of Darier's disease

Peterson¹,

Lesher²,

Sangüeza³

2001

Int J Dermatology

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“…The clinical and histological relation between brown papules and leukoderma has not yet been clarified, although it has been proposed that the leukoderma is caused by a reduction in the numbers of melanocytes and melanosomcs [2][3][4][5][6][7][9][10][11]. Hidaka [1][2][3] and Neumann [4] observed that the leukoderma changed to the typical brown Fig.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, Cattano [9] reported that the leukoderma rep resented postinflammatory depigmented spots occurring at the sites of once active lesions. However, Cornelison et al [10] did not conclude that the leukoderma was preceded by inflammation of the keratotic papules. We did not arrive at a definitive conclusion on the clinical changes between brown papules and leukoderma in our case, although the brown papules decreased and the leukoderma lesions increased in number within a 4-month period.…”

mentioning

confidence: 98%

“…The case of Bcrth-Jones and Hutchinson [11] showed only leukoderma and they considered it a subclinical dis ease, because the lesions showed typical histological fea tures of Darier's disease contrary to other cases [9,10] with brown papules and leukoderma. However, our case showed brown papules and leukoderma, and the latter as well as the brown papules were histologically typical of Darier's disease.…”

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confidence: 99%

“…The corneal layer of Mongoloid and Negroid people is flecked with melanin, although this is not ordinarily so in Cauca soids [12]. This may be related to the interesting fact that all patients with leukoderma [1][2][3][5][6][7][8][9][10][11], except that of Neu mann [4], were Asians or Negroes.…”

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confidence: 99%

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Brown Papules and Leukoderma in Darier’s Disease: Clinical and Histological Features

Ohtake¹,

Takano²,

Saitoh³

et al. 1994

Dermatology

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We report a Japanese case of Darier’s disease with brown and white papules or maculae distributed on the neck, trunk and dorsa of hands. Both brown papules and leukoderma showed typical histological features of Darier’s disease. Moreover, there were much fewer melanocytes and melanosomes in the epidermis of both lesions. The corneal layer of the brown papules was far thicker than that of the leukoderma. Therefore, the thick corneal layer of the brown papules may prolong the retention of a few melanosomes or a little melanin to induce hyperpigmentation, while the thin corneal layer of leukoderma may not do so, thereby producing hypopigmentation. The difference in clinical and histological courses after involvement of melanocytes was proposed to be the cause of the discrepancy between the previous reports. We conclude that leukoderma was the primary lesion, the postinflammatory depigmented spots, or the atypical or subclinical eruption of Darier’s disease.

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UV Radiation and Keratosis Follicularis

Baba¹

1984

Arch Dermatol

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Guttate Leukoderma in Darier's Disease

Cited by 19 publications

References 7 publications

A unique variant of Darier's disease

A unique variant of Darier's disease

Brown Papules and Leukoderma in Darier’s Disease: Clinical and Histological Features

UV Radiation and Keratosis Follicularis

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