Gut-to-brain regulation of
Drosophila
aging through neuropeptide F, insulin, and juvenile hormone
Jiangtian Chen,
Marcela Nouzová,
Fernando G. Noriega
et al.
Abstract:Dietary restriction (DR) slows aging in many animals, while in some cases, the sensory signals from diet alone are sufficient to retard or accelerate lifespan. The digestive tract is a candidate location to sense nutrients, where neuropeptides secreted by enteroendocrine cells (EEC) produce systemic signals in response to food. Here, we measure how
Drosophila
neuropeptide F (NPF) is secreted into adult circulation by EEC and find that specific EEC differentially respond to dietary sugar… Show more
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