Gut Remediation: Back to the Future

Ling, Zhenmin; Jiang, Yiming; Li, Xiangkai

doi:10.1007/978-981-15-4759-1_7

Cited by 3 publications

(3 citation statements)

References 97 publications

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“…Probiotics work together with the shaped gut microbiota to provide relief and treatment for associated disease symptoms. Li and coworkers 164 also defined the mechanism of probiotics in treating diseases through a “subtraction” approach as “gut remediation” and have conducted extensive research in this area.…”

Section: Effectiveness and Mechanisms Of Probiotics And Postbiotics I...mentioning

confidence: 99%

Probiotics, prebiotics, and postbiotics in health and disease

Ji,

Jin,

Liu

et al. 2023

MedComm

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The gut microbiota and its homeostasis play a crucial role in human health. However, for some diseases related to the gut microbiota, current traditional medicines can only relieve symptoms, and it is difficult to solve the root causes or even cause side effects like disturbances in the gut microbiota. Increasing clinical studies and evidences have demonstrated that probiotics, prebiotics, and postbiotics can prevent and treat various diseases, but currently they can only be used as dietary supplements rather than medicines, which restricts the application of probiotics in the field of medicine. Here, this review analyzes the importance of gut microbiota in human health and the current problems of traditional medicines, and systematically summarizes the effectiveness and mechanisms of probiotics, prebiotics, and postbiotics in maintaining health and treating diseases based on animal models and clinical trials. And based on current research outcomes and development trends in this field, the challenges and prospects of their clinical application in maintaining health, alleviating and treating diseases are analyzed. It is hoped to promote the application of probiotics, prebiotics, and postbiotics in disease treatment and open up new frontiers in probiotic research.

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Section: Effectiveness and Mechanisms Of Probiotics And Postbiotics I...mentioning

confidence: 99%

Probiotics, prebiotics, and postbiotics in health and disease

Ji,

Jin,

Liu

et al. 2023

MedComm

Self Cite

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“…Similar to other Gram-negative pathogens, A. baumannii secrete protein products in order to facilitate bacteria adaptation to different environmental conditions. Within the last five years, type I [53], type II [54][55], type IV [56], type V [57] and type VI [58][59] secretion systems have been described in A. baumannii. The trimeric autotransporter (Ata) was the first secretion system described in A. baumannii, which mediates the attachment to human matrix components, contributing to biofilm formation/maintenance and bacterial virulence [60].…”

Section: Secretion Systemsmentioning

confidence: 99%

“…More interestingly, before the absorption, probiotics may neutralize common toxic effects of cadmium from the intestinal region through the implication of the mechanism which abrogates the oxidative stress that relieves the induction of tissular toxicity [57]. Hence, a recent study provided several probiotic bacteria: Lactobacilli spp., B. longum, B. coagulans, genetically engineered E. coli, S. thermophilus, Pediococcus pentosaceus and S. cerevisiae were emphasized to exhibit preclinical alleviating effects on cadmium and mercury toxicity [58]. For example, yoghurt administration containing L. rhamnosus strains has previously minimized the concentrations of heavy metals (Hg and As) in children and pregnant women [8].…”

Section: Detoxification Of Heavy Metals and Toxic Compoundsmentioning

confidence: 99%

Untitled

2021

Roum Arch Microbiol Immunol

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An integrative approach of adaptive laboratory evolution, whole-genome sequencing and single-cell analysis was used to explore mechanisms related to establishment and maintenance of syntrophic interaction between sulfate-reducing Desulfovibrio vulgaris and methanogen Methanosarcina barkeri. Adaptive laboratory evolution of the D. vulgaris and M. barkeri dual-cultures under two different concentrations of electron donor lactate (38 mM and 50 mM) was conducted by propagating continuously for 50 transfers (~200 generations). Physiological analysis showed that, compared with the initial dual-cultures, the adapted dual-cultures (E38 and E50) have increased growth rates (1.1-fold and 1.2 -fold) and higher biomass yields (3.0-fold and 3.8-fold) on 38 mM and 50 mM lactate, respectively. Whole-genome re-sequencing of D. vulgaris in the adapted dualcultures revealed 11 and 12 mutations in the D. vulgaris genomes of E38 and E50 dual-cultures, respectively, among which 4 mutations were found in both adapted dual-cultures. RT-qPCR analysis showed that the expression levels of 8 mutated genes were gradually up-regulated in D. vulgaris along with the evolution process. In addition, their heterogeneity was found decreased along with the evolution, as revealed by singlecell RT-qPCR analysis, reflecting adjustments of both gene expression and gene heterogeneity to the gradually established syntrophic relationship.

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Adjuvant and Beneficial Probiotic Therapy for Women Health

Balta

Butucel

Mohylyuk

2021

Roum Arch Microbiol Immunol

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Probiotics are living microbial strains, also considered functional foods, that improve the human intestine and mucosal sites' functionality and normalize the immune system balance. This symbiosis between the human body and microorganisms has attracted scientists and showed a notable role in maintaining human health. The microbiota composition within different sites of the organs can change rapidly and unfavorably, leading to the development of infections or abnormal conditions. The treatments with antibiotics affect and disturb the overall normal microflora, and specifically to the vaginal tract, by inhibiting the spread of the normal microflora of Lactobacillus species. In this sense, probiotics have shown to be an integrative and complementary therapy for the amelioration and prevention of vaginal infections in women. The main objective of the current review is to highlight the importance of probiotics to prevent and treat antibiotic-associated acute and chronic diseases and highlight their possible beneficial impact on women reproductive health. Moreover, the review discusses the recent clinical findings of probiotic therapy concerning protection against vaginal diseases, well-being, infant development, and human body detoxification from the chemical compounds.

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Gut Remediation: Back to the Future

Cited by 3 publications

References 97 publications

Probiotics, prebiotics, and postbiotics in health and disease

Probiotics, prebiotics, and postbiotics in health and disease

Untitled

Adjuvant and Beneficial Probiotic Therapy for Women Health

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