Gut permeability and food allergies

Perrier, Clémentine; Corthésy, Blaise

doi:10.1111/j.1365-2222.2010.03639.x

Cited by 161 publications

(154 citation statements)

References 63 publications

(63 reference statements)

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…1,2 Perturbations in colonizing microbiota lead to the breakdown of the equilibrium between commensal and pathogenic microbes. This dysbiosis has been linked to the increased permeability of the epithelium 3,4 and the development of chronic inflammatory diseases, such as allergies and inflammatory bowel disease. [5][6][7] Allergies have become a serious health burden in developed countries.…”

Section: Introductionmentioning

confidence: 99%

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

et al. 2015

View full text Add to dashboard Cite

Increasing numbers of clinical trials and animal experiments have shown that probiotic bacteria are promising tools for allergy prevention. Here, we analyzed the immunomodulatory properties of three selected lactobacillus strains and the impact of their mixture on allergic sensitization to Bet v 1 using a gnotobiotic mouse model. We showed that Lactobacillus (L.) rhamnosus LOCK0900, L. rhamnosus LOCK0908 and L. casei LOCK0919 are recognized via Toll-like receptor 2 (TLR2) and nucleotide-binding oligomerization domain-containing protein 2 (NOD2) receptors and stimulate bone marrow-derived dendritic cells to produce cytokines in species-and strain-dependent manners. Colonization of germ-free (GF) mice with a mixture of all three strains (Lmix) improved the intestinal barrier by strengthening the apical junctional complexes of enterocytes and restoring the structures of microfilaments extending into the terminal web. Mice colonized with Lmix and sensitized to the Bet v 1 allergen showed significantly lower levels of allergen-specific IgE, IgG1 and IgG2a and an elevated total IgA level in the sera and intestinal lavages as well as an increased transforming growth factor (TGF)-b level compared with the sensitized GF mice. Splenocytes and mesenteric lymph node cells from the Lmix-colonized mice showed the significant upregulation of TGF-b after in vitro stimulation with Bet v 1. Our results show that Lmix colonization improved the gut epithelial barrier and reduced allergic sensitization to Bet v 1. Furthermore, these findings were accompanied by the increased production of circulating and secretory IgA and the regulatory cytokine TGF-b. Thus, this mixture of three lactobacillus strains shows potential for use in the prevention of increased gut permeability and the onset of allergies in humans. Cellular & Molecular Immunology

show abstract

Section: Introductionmentioning

confidence: 99%

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Estas uniones permiten el paso de moléculas pequeñas (<4 Å), pero también de moléculas mayores, como pequeños péptidos y lipopolisacáridos bacterianos entre 500 y 1500 Da (Perrier y Corthesy, 2011).…”

Section: Vías De Entrada De Los Antígenos Dietarios Por La Mucosa Intunclassified

“…La vía transcelular se puede producir a través de varios tipos celulares: las células M, los enterocitos y las células dendríticas (Perrier y Corthesy, 2011).…”

Section: Vías De Entrada De Los Antígenos Dietarios Por La Mucosa Intunclassified

“…La respuesta al consumo de altas cantidades de antígenos dietarios puede variar desde su ausencia hasta la inducción de inmunoglobulinas específicas como IgG e IgA en grandes cantidades. Estas diferencias se atribuyen a factores como la genética, la naturaleza del antígeno y su resistencia a la digestión (Perrier y Corthesy, 2011).…”

Section: Vías De Entrada De Los Antígenos Dietarios Por La Mucosa Intunclassified

“…También en este caso se observó un aumento de las IgG frente a los antígenos presentes en los hidrolizados de las distintas materias primas incluidas en la dieta, aunque de menor magnitud que el observado con los piensos que contenían harina de girasol, gluten de trigo, guisante o harina de soja como única fuente proteica. Se sabe que la intensidad de la reacción inmunitaria frente a antígenos dietarios depende, entre otras cosas, de la cantidad y naturaleza del antígeno (Perrier y Corthesy, 2011). La diversificación del origen de la proteína dietaria entre varias fuentes proteicas y la consiguiente reducción de sus niveles de inclusión puede ser una estrategia para la reducción de las reacciones inmunitarias frente a la dieta.…”

Section: Evolución De Las Igg Frente a Antígenos Dietarios En El Suerunclassified

See 2 more Smart Citations

Antigenicidad de piensos y materias primas proteicas en conejos

Cano¹,

Luís²

View full text Add to dashboard Cite

Secretory Immunoglobulin A

Corthésy

2013

Encyclopedia of Life Sciences

View full text Add to dashboard Cite

Secretory immunoglobulin A (IgA) (SIgA) is the most abundant Ig produced at the surface of mucosal membranes in mammals. These very thin and sensitive barriers are challenged by occasional pathogenic microbes as well as by permanently residing commensal bacteria. Although not the unique guardian of mucosal epithelia, SIgA is an important component of the protective function guaranteeing maintenance of homoeostasis and wellness. Topics presented in this article include: (1) mechanisms involved in local induction of SIgA via T‐cell‐dependent and ‐independent pathways; (2) structure–function relationship in SIgA; (3) immunoregulatory role of SIgA vis‐à‐vis pathogens and commensals and (4) the unexpected contribution of SIgA in diseases. Because this is the most studied mucosal environment, most of the functional characteristics of SIgA are exemplified with respect to the gastrointestinal tract. Key Concepts: SIgA is the most abundant immunoglobulin produced at mucosal surfaces, and it exists in secretions in polymeric forms of high and low antigenic affinity/avidity. The presence of secretory component in SIgA confers additional features including improved stability, proper anchoring in mucus and adequate localisation for optimal functions on the antibody. Because epithelia in the gastrointestinal, respiratory and urogenital tracts are highly sensitive to invading environmental antigens, shielding of mucosal surfaces by SIgA is crucial to the process of protection and homoeostasis. In addition to canonical immune exclusion, SIgA is endowed with the capacity to transport immune complexes via M‐cells to underlying dendritic cells, thus inducing attenuated mucosal and systemic immune responses. Communication between natural polyreactive SIgA‐commensal bacteria complexes and the epithelial cells lining mucosal surfaces contributes to regulate the symbiotic host–commensal relationship. SC, by itself, via multiple glycosylation sites, displays neutralising properties against pathogen‐associated molecules. This holds true when SC is bound to polymeric IgA in the SIgA molecule. Increasing knowledge of the multiple modes of action of SIgA provides opportunities to investigate the potential of the antibody in passive immunisation against bacteria, viruses and toxins in the clinics.

show abstract

Gut permeability and food allergies

Cited by 161 publications

References 63 publications

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

Antigenicidad de piensos y materias primas proteicas en conejos

Secretory Immunoglobulin A

Contact Info

Product

Resources

About