Gut modulation of dysbiosis induced by dextran sulfate sodium

Kozhakhmetov, Samat; Babenko, Dmitriy; Kozhakhmetova, Saniya; Tuyakova, Altynay; Nurgaziyev, Madiyar; Nurgozhina, Ayaulym; Muhanbetganov, Nurislam; Chulenbayeva, Laura; Sergazy, Shynggys; Gulyaev, A. E.; Tanabayev, Baimakhan; Saliev, Timur; Kushugulova, Аlmagul

doi:10.1016/j.fbio.2021.101167

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…For community-level comparisons, such as estimation of beta diversity, Total sum scaling normalization (TSS) was performed. Regarding DSS treatment (in this study for 10 days), it was established that the alpha diversity tends to decrease [33,34]. In both groups (DSS + Vehicle and DSS + SFE20), after treatment with DSS (either with vehicle or Saffron), there was a decrease in alpha diversity, which shows that, with DSS treatment, there is a decrease in alpha diversity index irrespective of Saffron intervention.…”

Section: Microbiome Analysismentioning

confidence: 54%

Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model

Singh

Brim

Haileselassie

et al. 2023

CIMB

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Despite the existence of effective drugs used to treat inflammatory bowel disease (IBD), many patients fail to respond or lose response over time. Further, many drugs can carry serious adverse effects, including increased risk of infections and malignancies. Saffron (Crocus sativus) has been reported to have anti-inflammatory properties. Its protective role in IBD and how the microbiome and metabolome play a role has not been explored extensively. We aimed to establish whether saffron treatment modulates the host microbiome and metabolic profile in experimental colitis. Colitis was induced in C57BL/6 mice with 3% DSS and treated with either saffron in a dose of 20 mg/kg body weight or vehicle through daily gavage. On day 10, stool pellets from mice were collected and analyzed to assess saffron’s effect on fecal microbiota and metabolites through 16S rRNA sequencing and untargeted primary metabolite analysis. Saffron treatment maintained gut microbiota homeostasis by counter-selecting pro-inflammatory bacteria and maintained Firmicutes/Bacteroides ratio, which was otherwise disturbed by DSS treatment. Several metabolites (uric acid, cholesterol, 2 hydroxyglutaric acid, allantoic acid, 2 hydroxyhexanoic acid) were altered significantly with saffron treatment in DSS-treated mice, and this might play a role in mediating saffron’s colitis-mitigating effects. These data demonstrate saffron’s therapeutic potential, and its protective role is modulated by gut microbiota, potentially acting through changes in metabolites.

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Section: Microbiome Analysismentioning

confidence: 54%

Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model

Singh

Brim

Haileselassie

et al. 2023

CIMB

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“…60 Besides, Monoglobus can degrade polysaccharides to produce SCFAs, which may be related to the degradation of TSP. 61 These results suggested that the prepared complexes might alleviate ulcerative colitis in DSS-treated mice by promoting the growth of beneficial bacteria, especially in the complexes containing TSP.…”

Section: Resultsmentioning

confidence: 89%

Fabrication of zein–tamarind seed polysaccharide–curcumin nanocomplexes: their characterization and impact on alleviating colitis and gut microbiota dysbiosis in mice

Xie,

Zhu,

Zeng

et al. 2024

Food Funct.

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“…The mouse model of DSS-induced colitis is a well-established model for studies of enteritis, and manifests symptoms (weight loss, diarrhea, blood in stool) similar to those in human clinical cases. [28,29] In preliminary experiments, separate treatments with L. rhamnosus BY-02 and L. plantarum BY-05 had a limited ameliorative effect in the mouse model. The combined use of the two strains was more effective than single strains in relieving colitis.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus rhamnosus and L. plantarum Combination Treatment Ameliorated Colitis Symptoms in a Mouse Model by Altering Intestinal Microbial Composition and Suppressing Inflammatory Response

Liu

Zhang

Xie

et al. 2023

Molecular Nutrition Food Res

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Scope Changes in composition of intestinal microbes may disrupt the balance of their interaction with a susceptible host, resulting in development of inflammatory bowel disease (IBD). Methods and results The study applied in combination two Lactobacillus strains (L. rhamnosus BY‐02, L. plantarum BY‐05) (“LS treatment”), previously isolates from feces of healthy human infants, in a mouse model of dextran sodium sulfate (DSS)‐induced colitis, and evaluates their ameliorative effect and its possible mechanism. LS treatment suppresses weight loss and colon shortening, and reduces disease activity index in the mice. It also has several additional beneficial effects: i) maintains goblet cell numbers and ameliorates intestinal barrier damage in colonic tissue; ii) alters intestinal microbial composition close to normal by increasing abundances of Muribaculaceae, Akkermansia, Clostridia, Oscillospiraceae, and Lachnospiraceae, and decreasing abundance of Escherichia‐Shigella; iii) increases content of short‐chain fatty acids; iv) reduces content of pro‐inflammatory lipopolysaccharides; v) suppresses overactivation of TLR4/NF‐κB inflammatory signaling pathway. Conclusion Combination treatment with two Lactobacillus strains strongly ameliorates colitis symptoms in the mouse model by favorably altering intestinal microbial composition and suppressing inflammatory response.

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Gut modulation of dysbiosis induced by dextran sulfate sodium

Cited by 6 publications

References 23 publications

Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model

Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model

Fabrication of zein–tamarind seed polysaccharide–curcumin nanocomplexes: their characterization and impact on alleviating colitis and gut microbiota dysbiosis in mice

Lactobacillus rhamnosus and L. plantarum Combination Treatment Ameliorated Colitis Symptoms in a Mouse Model by Altering Intestinal Microbial Composition and Suppressing Inflammatory Response

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