Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension

Zhao, Zeyu; Guo, Zhengchang; Yin, Zhengliang; Qiu, Yue; Zhou, Bo

doi:10.3389/fphys.2021.790182

Cited by 5 publications

(5 citation statements)

References 40 publications

(41 reference statements)

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“…Escherichia_Shigella can adversely affect liver lipid metabolism [51]. Zhao et al [52] found that increases in the relative abundance levels of Proteobacteria and Escherichia_Shigella in the intestine of rats can cause liver damage. In the present study, compared with levels in the CG, the relative abundance levels of Proteobacteria and Escherichia_Shigella in the MG were increased.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Ganoderma lucidum Spore Powder on Acute Liver Injury in Mice and its Regulation of Gut Microbiota

Leng¹,

Wang²,

Chen³

et al. 2023

Front. Biosci. (Landmark Ed)

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Background: Ganoderma lucidum spore powder (GLSP) has abundant pharmacological activities. However, the difference in the hepatoprotective function of sporoderm-broken and sporoderm-unbroken Ganoderma spore powder has not been studied. This study is the first to investigate the effects of both sporoderm-damaged and sporoderm-intact GLSP on the improvement of acute alcoholic liver injury in mice and gut microbiota of mice. Methods: Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and interleukin 1β (IL-1β), interleukin 18 (IL-18), and tumor necrosis factor-α (TNF-α) levels in liver tissues from mice in each group were detected by enzyme-linked immunosorbent assay (ELISA) kits, and histological analysis of liver tissue sections was performed to evaluate the liver-protecting effects of both sporoderm-broken and sporoderm-unbroken GLSP. Additionally, 16S rDNA sequencing of feces from the bowels of mice was performed to compare the regulatory effects of both sporoderm-broken and sporoderm-unbroken GLSP on the gut microbiota of mice. Results: Compared with those in the 50% ethanol model group (MG), sporoderm-broken GLSP significantly reduced serum AST and ALT levels (p < 0.0001) and the release of the inflammatory factors, including IL-1β, IL-18, and TNF-α (p < 0.0001), and effectively improved the pathological state of liver cells; sporoderm-unbroken GLSP significantly reduced the ALT content (p = 0.0002) and the release of the inflammatory factors, including IL-1β (p < 0.0001), IL-18 (p = 0.0018), and TNF-α (p = 0.0005), and reduced the serum AST content, but the reduction was not significant; compared with the gut microbiota of the MG, sporoderm-broken GLSP reduced the levels of Verrucomicrobia and Escherichia_Shigella, increased the relative abundance of beneficial bacteria such as Bacteroidetes, and decreased the abundance levels of harmful bacteria, such as Proteobacteria and Candidatus_Saccharibacteria; sporoderm-unbroken GLSP could reduce the abundance levels of harmful bacteria, such as Verrucomicrobia and Candidatus_Saccharibacteria; and GLSP treatment alleviates the downregulation of the levels of translation, ribosome structure and biogenesis, and lipid transport and metabolism in liver-injured mice; Conclusions: GLSP can alleviate the imbalance of gut microbiota and improve liver injury, and the effect of sporoderm-broken GLSP is better.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Ganoderma lucidum Spore Powder on Acute Liver Injury in Mice and its Regulation of Gut Microbiota

Leng¹,

Wang²,

Chen³

et al. 2023

Front. Biosci. (Landmark Ed)

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“…Another future approach to reduce the influence of CIT on IAH and ACS could be machine perfusion of donor organs. Regarding the pathomechanism of organ injury due to IAH/ACS, Zhao et al published an interesting animal study [ 41 ] showing that IAH/ACS-induced gut microbiota dysbiosis highly contributes to liver injury. Our study provides vital basics for future investigations into these relevant aspects of the pLT setting.…”

Section: Discussionmentioning

confidence: 99%

Intra-Abdominal Hypertension and Compartment Syndrome after Pediatric Liver Transplantation: Incidence, Risk Factors and Outcome

et al. 2022

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In pediatric liver transplantation (pLT), the risk for the manifestation and relevance of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) is high. This observational study aimed to evaluate the incidence, relevance and risk factors for IAH and ACS by monitoring the intra-abdominal pressure (IAP), macro- and microcirculation (near-infrared spectroscopy (NIRS)), clinical and laboratory status and outcomes of 27 patients (16 female) after pLT (median age at pLT 35 months). Of the patients, 85% developed an elevated IAP, most of them mild. However, 17% achieved IAH° 3, 13% achieved IAH° 4 and 63% developed ACS. A multiple linear regression analysis identified aortal hepatic artery anastomosis and cold ischemia time (CIT) as risk factors for increased IAP and longer CIT and staged abdominal wall closure for ACS. ACS patients had significantly longer mechanical ventilation (p = 0.004) and LOS-PICU (p = 0.003). No significant correlation between NIRS or biliary complications and IAH or ACS could be shown. IAH and ACS after pLT were frequent. NIRS or grade of IAH alone should not be used for monitoring. A longer CIT is an important risk factor for higher IAP and ACS. Therefore, approaches such as the ex vivo machine perfusion of donor organs, reducing CIT effects on them, have great potential. Our study provides important basics for studying such approaches.

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“…The primary disease combined with IAH and vasomotor changes quickly induces a pathological gut microflora or dysbiome that has adverse consequences for the host 25 . Animal studies have reported that IAH decreases the abundance and diversity of the gut microbiota and increases the relative amounts of pathogenic lipopolysaccharide-secreting Proteobacteria 26 , 27 . Further, dysbiotic faeces from previously IAH-injured rats exacerbates the injury 27 .…”

Section: The Open Abdomen In Intra-abdominal Sepsismentioning

confidence: 99%

“…Animal studies have reported that IAH decreases the abundance and diversity of the gut microbiota and increases the relative amounts of pathogenic lipopolysaccharide-secreting Proteobacteria 26 , 27 . Further, dysbiotic faeces from previously IAH-injured rats exacerbates the injury 27 .…”

Section: The Open Abdomen In Intra-abdominal Sepsismentioning

confidence: 99%

The open abdomen in trauma, acute care, and vascular and endovascular surgery: comprehensive, expert, narrative review

Roberts,

Leppäniemi,

Tolonen

et al. 2023

BJS Open

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Background The open abdomen is an innovation that greatly improved surgical understanding of damage control, temporary abdominal closure, staged abdominal reconstruction, viscera and enteric fistula care, and abdominal wall reconstruction. This article provides an evidence-informed, expert, comprehensive narrative review of the open abdomen in trauma, acute care, and vascular and endovascular surgery. Methods A group of 12 international trauma, acute care, and vascular and endovascular surgery experts were invited to review current literature and important concepts surrounding the open abdomen. Results The open abdomen may be classified using validated systems developed by a working group in 2009 and modified by the World Society of the Abdominal Compartment Syndrome—The Abdominal Compartment Society in 2013. It may be indicated in major trauma, intra-abdominal sepsis, vascular surgical emergencies, and severe acute pancreatitis; to facilitate second look laparotomy or avoid or treat abdominal compartment syndrome; and when the abdominal wall cannot be safely closed. Temporary abdominal closure and staged abdominal reconstruction methods include a mesh/sheet, transabdominal wall dynamic fascial traction, negative pressure wound therapy, and hybrid negative pressure wound therapy and dynamic fascial traction. This last method likely has the highest primary fascial closure rates. Direct peritoneal resuscitation is currently an experimental strategy developed to improve primary fascial closure rates and reduce complications in those with an open abdomen. Primary fascial closure rates may be improved by early return to the operating room; limiting use of crystalloid fluids during the surgical interval; and preventing and/or treating intra-abdominal hypertension, enteric fistulae, and intra-abdominal collections after surgery. The majority of failures of primary fascial closure and enteroatmospheric fistula formation may be prevented using effective temporary abdominal closure techniques, providing appropriate resuscitation fluids and nutritional support, and closing the abdomen as early as possible. Conclusion Subsequent stages of the innovation of the open abdomen will likely involve the design and conduct of prospective studies to evaluate appropriate indications for its use and effectiveness and safety of the above components of open abdomen management.

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Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension

Cited by 5 publications

References 40 publications

Protective Effect of Ganoderma lucidum Spore Powder on Acute Liver Injury in Mice and its Regulation of Gut Microbiota

Protective Effect of Ganoderma lucidum Spore Powder on Acute Liver Injury in Mice and its Regulation of Gut Microbiota

Intra-Abdominal Hypertension and Compartment Syndrome after Pediatric Liver Transplantation: Incidence, Risk Factors and Outcome

The open abdomen in trauma, acute care, and vascular and endovascular surgery: comprehensive, expert, narrative review

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