Gut Microbiota: the Emerging Link to Lung Homeostasis and Disease

Zhou, An; Lei, Yuanyuan; Tang, Li; Hu, Shiping; Ye, Min; Wu, Ling-Yi; Yang, Shiming; Tang, Bo

doi:10.1128/jb.00454-20

Cited by 45 publications

(32 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, S24_7 (Muribaculaceae) beneficial bacteria, were seen both in the lungs and the gut of the SEB + AEA group. These findings supported the concept of crosstalk between gut and lung microbiomes [ 71 , 72 , 73 ]. Our study also indicated that AEA treatment led to a decrease in the abundance of the order Pseudomonas and Caulobacterlaes, which are both believed to cause human respiratory tract infections [ 38 , 74 ].…”

Section: Discussionsupporting

confidence: 86%

Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis

Sultan

Wilson

Abdulla

et al. 2021

Cells

View full text Add to dashboard Cite

Acute respiratory distress syndrome (ARDS) is a serious lung condition characterized by severe hypoxemia leading to limitations of oxygen needed for lung function. In this study, we investigated the effect of anandamide (AEA), an endogenous cannabinoid, on Staphylococcal enterotoxin B (SEB)-mediated ARDS in female mice. Single-cell RNA sequencing data showed that the lung epithelial cells from AEA-treated mice showed increased levels of antimicrobial peptides (AMPs) and tight junction proteins. MiSeq sequencing data on 16S RNA and LEfSe analysis demonstrated that SEB caused significant alterations in the microbiota, with increases in pathogenic bacteria in both the lungs and the gut, while treatment with AEA reversed this effect and induced beneficial bacteria. AEA treatment suppressed inflammation both in the lungs as well as gut-associated mesenteric lymph nodes (MLNs). AEA triggered several bacterial species that produced increased levels of short-chain fatty acids (SCFAs), including butyrate. Furthermore, administration of butyrate alone could attenuate SEB-mediated ARDS. Taken together, our data indicate that AEA treatment attenuates SEB-mediated ARDS by suppressing inflammation and preventing dysbiosis, both in the lungs and the gut, through the induction of AMPs, tight junction proteins, and SCFAs that stabilize the gut-lung microbial axis driving immune homeostasis.

show abstract

Section: Discussionsupporting

confidence: 86%

Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis

Sultan

Wilson

Abdulla

et al. 2021

Cells

View full text Add to dashboard Cite

show abstract

“…Additionally, many recent studies demonstrate the importance of the gut microbiome in modulating immune responses and changes in the gut microbiota alter immune responses and homeostasis in the respiratory system [22]. It is surmised that this cross-talk occurs through the production of metabolites, endotoxins and cytokines by the gut microbiota which travel to the respiratory mucosa through the bloodstream [23]. Some more recent studies suggest that this cross-talk is bidirectional, with the lung microbiota potentially mediating immunologic responses in the gut [24,25].…”

Section: The Lung Microbiome and Lung Cancermentioning

confidence: 99%

The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?

Weinberg

Dickson

Nagrath

et al. 2020

Cancers

View full text Add to dashboard Cite

Lung cancer is the leading cause of cancer-related death. Over the past 5–10 years lung cancer outcomes have significantly improved in part due to better treatment options including immunotherapy and molecularly targeted agents. Unfortunately, the majority of lung cancer patients do not enjoy durable responses to these new treatments. Seminal research demonstrated the importance of the gut microbiome in dictating responses to immunotherapy in melanoma patients. However, little is known regarding how other sites of microbiota in the human body affect tumorigenesis and treatment responses. The lungs were traditionally thought to be a sterile environment; however, recent research demonstrated that the lung contains its own dynamic microbiota that can influence disease and pathophysiology. Few studies have explored the role of the lung microbiome in lung cancer biology. In this review article, we discuss the links between the lung microbiota and cancer, with particular focus on immune responses, metabolism and strategies to target the lung microbiome for cancer prevention.

show abstract

“…However, the beta diversity analysis showed a significant difference in the microbial composition ( Figure 2 ). It has been reported that the gut microbial composition in healthy humans is significantly different from that in patients with cancers, including lung cancer [ 25 , 41 , 42 ]. Therefore, an alteration of the gut microbiota composition appears to be significantly influential on carcinogenesis in the lung.…”

Section: Discussionmentioning

confidence: 99%

Oral Administration of Water Extract from Euglena gracilis Alters the Intestinal Microbiota and Prevents Lung Carcinoma Growth in Mice

et al. 2022

View full text Add to dashboard Cite

The antitumor effects of a partially purified water extract from Euglena gracilis (EWE) and EWE treated by boiling (bEWE) were evaluated using orthotopic lung cancer syngeneic mouse models with Lewis lung carcinoma (LLC) cells. Daily oral administration of either EWE or bEWE started three weeks prior to the inoculation of LLC cells significantly attenuated tumor growth as compared to the phosphate buffered saline (PBS) control, and the attenuation was further enhanced by bEWE. The intestinal microbiota compositions in both extract-treated groups were more diverse than that in the PBS group. Particularly, a decrease in the ratio of Firmicutes to Bacteroidetes and significant increases in Akkermansia and Muribaculum were observed in two types of EWE-treated groups. Fecal microbiota transplantation (FMT) using bEWE-treated mouse feces attenuated tumor growth to an extent equivalent to bEWE treatment, while tumor growth attenuation by bEWE was abolished by treatment with an antibiotic cocktail. These studies strongly suggest that daily oral administration of partially purified water extracts from Euglena gracilis attenuates lung carcinoma growth via the alteration of the intestinal microbiota.

show abstract

Gut Microbiota: the Emerging Link to Lung Homeostasis and Disease

Cited by 45 publications

References 98 publications

Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis

Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis

The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?

Oral Administration of Water Extract from Euglena gracilis Alters the Intestinal Microbiota and Prevents Lung Carcinoma Growth in Mice

Contact Info

Product

Resources

About