Gut microbiota shape B cell in health and disease settings

Yu, Baichao; Wang, Luman; Chu, Yiwei

doi:10.1002/jlb.1mr0321-660r

Cited by 12 publications

(5 citation statements)

References 129 publications

(263 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 ). We also note that many of the affected taxa are well-known producers of SCFAs, which have a pivotal role in the regulation of gut immunity and the maintenance of an intact immune barrier 76 – 78 . More specifically, Liu et al 70 reported that newly diagnosed children with ALL exhibit reduced relative abundance of both butyrate-producing species ( Roseburia faecis , R. intestinalis , R. inulinivorans , Anaerostipes hardus, Faecalibacterium prausnitzii , Eubacterium ramulus ) and acetate-producing species ( Prevotella maculosa , P. aurantiaca , Bacteroides uniformis , B. ovatus ) (Supplementary Fig.…”

Section: Gut Dysbiosis In Children With Allmentioning

confidence: 91%

“…Microbial signals at the level of the intestinal mucosa, such as microorganism-associated molecular patterns (MAMPs) 68 and microorganism-derived metabolites (for example, SCFAs) 82 , are thus utilized for mediating immune training 83 , 84 . Principal aspects of this gut microbiome–immune system interplay include the induction of T reg cells that orchestrate the complex immune network, as well as modulation of various aspects of B cell development 78 , 85 – 87 .…”

Section: Gut Dysbiosis In Children With Allmentioning

confidence: 99%

See 1 more Smart Citation

Gut microbiome immaturity and childhood acute lymphoblastic leukaemia

et al. 2023

View full text Add to dashboard Cite

Acute lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Here, we map emerging evidence suggesting that children with ALL at the time of diagnosis may have a delayed maturation of the gut microbiome compared with healthy children. This finding may be associated with early-life epidemiological factors previously identified as risk indicators for childhood ALL, including caesarean section birth, diminished breast feeding and paucity of social contacts. The consistently observed deficiency in short-chain fatty-acid-producing bacterial taxa in children with ALL has the potential to promote dysregulated immune responses and to, ultimately, increase the risk of transformation of preleukaemic clones in response to common infectious triggers. These data endorse the concept that a microbiome deficit in early life may contribute to the development of the major subtypes of childhood ALL and encourage the notion of risk-reducing microbiome-targeted intervention in the future.

show abstract

Section: Gut Dysbiosis In Children With Allmentioning

confidence: 91%

Section: Gut Dysbiosis In Children With Allmentioning

confidence: 99%

Gut microbiome immaturity and childhood acute lymphoblastic leukaemia

et al. 2023

View full text Add to dashboard Cite

show abstract

“…B cell activation and differentiation can be triggered through either T-dependent or T-independent mechanisms. In both cases, the initial signal that initiates the activation cascade relies on the recognition of antigens via the B cell receptor in T-dependent activation, or via Toll-like receptors in T-independent activation [ 56 ]. These antigens are typically derived from foreign proteins, polysaccharides, or metabolites from viral, fungal, or bacterial sources [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer

Zorea

Motro

Mazor

et al. 2023

J Exp Clin Cancer Res

View full text Add to dashboard Cite

Background Ovarian cancer (OC) is known for exhibiting low response rates to immune checkpoint inhibitors that activate T cells. However, immunotherapies that activate B cells have not yet been extensively explored and may be a potential target, as B cells that secrete immunoglobulins have been associated with better outcomes in OC. Although the secretion of immunoglobulins is often mediated by the microbiome, it is still unclear what role they play in limiting the progression of OC. Methods We conducted an in-vivo CRISPR screen of immunodeficient (NSG) and immune-intact wild type (WT) C57/BL6 mice to identify tumor-derived immune-escape mechanisms in a BRAC1- and TP53-deficient murine ID8 OC cell line (designated ITB1). To confirm gene expression and signaling pathway activation in ITB1 cells, we employed western blot, qPCR, immunofluorescent staining, and flow cytometry. Flow cytometry was also used to identify immune cell populations in the peritoneum of ITB1-bearing mice. To determine the presence of IgA-coated bacteria in the peritoneum of ITB1-bearing mice and the ascites of OC patients, we employed 16S sequencing. Testing for differences was done by using Deseq2 test and two-way ANOVA test. Sequence variants (ASVs) were produced in Qiime2 and analyzed by microeco and phyloseq R packages. Results We identified tumor necrosis factor receptor-associated factor 3 (TRAF3) as a tumor-derived immune suppressive mediator in ITB1 cells. Knockout of TRAF3 (TRAF3KO) activated the type-I interferon pathway and increased MHC-I expression. TRAF3KO tumors exhibited a growth delay in WT mice vs. NSG mice, which was correlated with increased B cell infiltration and activation compared to ITB1 tumors. B cells were found to be involved in the progression of TRAF3KO tumors, and B-cell surface-bound and secreted IgA levels were significantly higher in the ascites of TRAF3KO tumors compared to ITB1. The presence of commensal microbiota was necessary for B-cell activation and for delaying the progression of TRAF3KO tumors in WT mice. Lastly, we observed unique profiles of IgA-coated bacteria in the ascites of OC-bearing mice or the ascites of OC patients. Conclusions TRAF3 is a tumor-derived immune-suppressive modulator that influences B-cell infiltration and activation, making it a potential target for enhancing anti-tumor B-cell responses in OC.

show abstract

“…Microbial antigens activate B cells directly via the BCR or TLRs. In contrast, microbial metabolites act directly on B cells to trigger their activation and differentiation into regulatory B cells, which produce regulatory cytokines or plasma cells that secrete anti-commensal antibodies; see the review in Yu et al [ 96 ].…”

Section: Human Intestinal Microbiota In Health and Cardiovascular Dis...mentioning

confidence: 99%

Polyphenols–Gut–Heart: An Impactful Relationship to Improve Cardiovascular Diseases

et al. 2022

View full text Add to dashboard Cite

A healthy gut provides the perfect habitat for trillions of bacteria, called the intestinal microbiota, which is greatly responsive to the long-term diet; it exists in a symbiotic relationship with the host and provides circulating metabolites, hormones, and cytokines necessary for human metabolism. The gut–heart axis is a novel emerging concept based on the accumulating evidence that a perturbed gut microbiota, called dysbiosis, plays a role as a risk factor in the pathogenesis of cardiovascular disease. Consequently, recovery of the gut microbiota composition and function could represent a potential new avenue for improving patient outcomes. Despite their low absorption, preclinical evidence indicates that polyphenols and their metabolites are transformed by intestinal bacteria and halt detrimental microbes’ colonization in the host. Moreover, their metabolites are potentially effective in human health due to antioxidant, anti-inflammatory, and anti-cancer effects. The aim of this review is to provide an overview of the causal role of gut dysbiosis in the pathogenesis of atherosclerosis, hypertension, and heart failure; to discuss the beneficial effects of polyphenols on the intestinal microbiota, and to hypothesize polyphenols or their derivatives as an opportunity to prevent and treat cardiovascular diseases by shaping gut eubiosis.

show abstract

Gut microbiota shape B cell in health and disease settings

Cited by 12 publications

References 129 publications

Gut microbiome immaturity and childhood acute lymphoblastic leukaemia

Gut microbiome immaturity and childhood acute lymphoblastic leukaemia

TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer

Polyphenols–Gut–Heart: An Impactful Relationship to Improve Cardiovascular Diseases

Contact Info

Product

Resources

About