Gut Microbiota-Related Evidence Provides New Insights Into the Association Between Activating Transcription Factor 4 and Development of Salt-Induced Hypertension in Mice

Liu, Tianhao; Tao, Wencong; Liang, Qiuer; Tu, Wan-qing; Ye, Xiao; Chen, Liguo

doi:10.3389/fcell.2020.585995

Cited by 21 publications

(23 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bacteroides have a well characterized pathway to synthesize menaquinones (Vit K 2 ) 30 and it was recently demonstrated that the gut microbiota regulate endothelial function and blood pressure via a vitamin K 2 -dependent pathway. 31 It is interesting to speculate whether loss or reduction of bacterially-synthesized K 2 may have driven the results observed in this study. However, it is also important to note that there were several Bacteroides sp.…”

Section: Discussionmentioning

confidence: 85%

Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance

et al. 2021

View full text Add to dashboard Cite

Recent preclinical data suggest that alterations in the gut microbiota may be an important factor linking obesity to vascular dysfunction, an early sign of cardiovascular disease. The purpose of this study was to begin translation of these preclinical data by examining whether vascular phenotypes in humans are transmissible through the gut microbiota. We hypothesized that germ-free mice colonized with gut microbiota from obese individuals would display diminished vascular function compared to germ-free mice receiving microbiota from lean individuals.We transplanted fecal material from obese and lean age-and sex-matched participants with disparate vascular function to germ-free mice. Using Principle Component Analysis, the microbiota of colonized mice separated by donor group along the first principle component, accounting for between 70-93% of the total variability in the dataset. The microbiota of mice receiving transplants from lean individuals was also characterized by increased alpha diversity, as well as increased relative abundance of potentially beneficial bacteria, including Bifidobacterium, Lactobacillus, and Bacteroides ovatis. Endothelium-dependent dilation, aortic pulse wave velocity and glucose tolerance were significantly altered in mice receiving microbiota from the obese donor relative to those receiving microbiota from the lean donor or those remaining germ-free.These data indicate that the obesity-associated human gut microbiota is sufficient to alter the vascular phenotype in germ-free mice in the absence of differences in body weight or dietary manipulation, and provide justification for future clinical trials to test the efficacy of microbiotatargeted therapies in the prevention or treatment of cardiovascular disease.

show abstract

Section: Discussionmentioning

confidence: 85%

Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Clostridium_sensu_stricto_1, Alistipes, Lachnoclostridium, and Desulfovibrio are opportunistic pathogens that may cause infection, aggravate inflammation, or worsen clinical conditions (25,(37)(38)(39)(40)(41). The exact functions of Blautia, Lachnospira, Fusicatenibacter, Dubosiella, and Agathobacter are not clear, but some researchers think they may have some relationship with some diseases (32,(42)(43)(44)(45)(46)(47)(48). Faecalibacterium is beneficial to humans (49,50).…”

Section: Discussionmentioning

confidence: 99%

Evolution of Intestinal Microbiota of Asphyxiated Neonates Within 1 Week and Its Relationship With Neural Development at 6 Months

et al. 2021

View full text Add to dashboard Cite

Introduction: Asphyxia is an emergent condition in neonates that may influence the function of the nervous system. Research has shown that intestinal microbiota is very important for neurodevelopment. Studies regarding the association between gut microbiota and neurodevelopment outcome in asphyxiated newborns remain scarce.Objective: To study the microbial characteristics of asphyxiated neonates within 1 week of life and to investigate their relationship with neural development at 6 months.Methods: The feces produced on days 1, 3, and 5, and the clinical data of full-term neonates with asphyxia and without asphyxia, delivered from March 2019 to October 2020 at Peking University First Hospital, were collected. We used 16S ribosomal deoxyribonucleic acid amplicon sequencing to detect the intestinal microbiota of asphyxiated neonates and neonates in the control group. We followed up asphyxiated neonates for 6 months and used the Ages and Stages Questionnaires-3 (ASQ-3) to evaluate their development.Results: A total of 45 neonates were enrolled in the study group and 32 were enrolled in the control group. On day 1, the diversity and richness of the microflora of the study group were more than those of the control group. Non-metric multidimensional scaling analysis showed significant differences in the microbiota of the two groups on days 1, 3, and 5. At the phylum level, the main microflora of the two groups were not different. At the genus level, the study group had increased relative abundance of Clostridium_sensu_stricto_1, Lachnoclostridium, Fusicatenibacter, etc. on day 1. On day 3, the relative abundance of Clostridium_sensu_stricto_1, Fusicatenibacter, etc. was still greater than that of the control group, and the relative abundance of Staphylococcus was less than that of the control group. On day 5, the relative abundance of Clostridium_sensu_stricto_1 and Lachnoclostridium was still higher than that of the control group, and the relative abundance of Dubosiella in the study group was significantly increased. At the species level, on day 3, the relative abundance of Staphylococcus caprae in the study group was less than that in the control group. Linear discriminant analysis effect size showed that the microbiota of the study group mainly consisted of Lachnospiraceae and Clostridia on day 1 and Clostridia on day 3. In the control group, Staphylococcus was the dominant bacterium on day 3. Neonates in the study group were followed up for 6 months, and the communication score of ASQ-3 was negatively correlated with the relative abundance of Lachnospiraceae and Clostridia on day 1.Conclusion: The diversity and richness of the microbiota of asphyxiated neonates on the first day of life were significantly increased and mainly consisted of pathogenic flora. Lachnospiraceae and Clostridia found in neonates with asphyxia on day 1 of life may be related to neural development at 6 months.

show abstract

“…A previous study reported that proteins involved in apoptosis are overexpressed in TAO [6]. Some proteins processed in the endoplasmic reticulum are upregulated in TAO versus GD patients [16]. Cytoskeleton-associated protein 4 (CKAP4) is an endoplasmic reticulum protein that regulates cell migration and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…Cytoskeleton‐associated protein 4 (CKAP4) is an endoplasmic reticulum protein that regulates cell migration and apoptosis. Fei et al [16] found that CKAP4 induces apoptosis. UBR1, an E3 ubiquitin ligase, plays a role in the N‐end rule degradation pathway and downregulates the mTOR pathway [17].…”

Section: Discussionmentioning

confidence: 99%

Differentiation between thyroid‐associated orbitopathy and Graves’ disease by iTRAQ‐based quantitative proteomic analysis

Kang

Zhao

et al. 2021

FEBS Open Bio

View full text Add to dashboard Cite

show abstract

Gut Microbiota-Related Evidence Provides New Insights Into the Association Between Activating Transcription Factor 4 and Development of Salt-Induced Hypertension in Mice

Cited by 21 publications

References 46 publications

Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance

Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance

Evolution of Intestinal Microbiota of Asphyxiated Neonates Within 1 Week and Its Relationship With Neural Development at 6 Months

Differentiation between thyroid‐associated orbitopathy and Graves’ disease by iTRAQ‐based quantitative proteomic analysis

Contact Info

Product

Resources

About