Gut Microbiota Plays Essential Roles in Soyasaponin's Preventive Bioactivities against Steatohepatitis in the Methionine and Choline Deficient (MCD) Diet‐Induced Non‐Alcoholic Steatohepatitis (NASH) Mice
Chuhong Su,
Jiexian Wang,
Huiyu Luo
et al.
Abstract:ScopeGut microbiota (GM) is involved in nonalcoholic steatohepatitis (NASH) development. Phytochemicals soyasaponins can prevent NASH possibly by modulating GM. This study aims to investigate the preventive bioactivities of soyasaponin monomers (SS‐A1 and SS‐Bb) against NASH and explores the mechanisms by targeting GM.Methods and resultsMale C57BL/6 mice are fed with methionine and choline deficient (MCD) diet containing SS‐A1, SS‐Bb, or not for 16 weeks. Antibiotics‐treated pseudo germ‐free (PGF) mice are fed… Show more
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