Gut microbiota orchestrates PTH action in bone: role of butyrate and T cells

Massy, Ziad A.; Drueke, Tilman B.

doi:10.1016/j.kint.2020.03.004

Cited by 8 publications

(5 citation statements)

References 9 publications

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“… 119 Together, 19 Wnt proteins exert their effects through binding to Frizzled receptors and LRPs as coreceptors, including LRP5 and LRP6. 120 , 121 To date, three Wnt signaling pathways have been discovered, including one canonical Wnt pathway (i.e., the canonical Wnt/β-catenin signaling pathway) and two noncanonical Wnt pathways, including the Wnt/Ca 2+ -dependent pathway and the Wnt/planar cell polarity pathway. 122 , 123 The canonical Wnt/β-catenin signaling pathway plays a critical role in osteoporosis, mainly by promoting the differentiation of mesenchymal progenitor cells into osteoblasts.…”

Section: Molecular Mechanisms Underlying Sexual Dimorphism In Osteopo...mentioning

confidence: 99%

Insights and implications of sexual dimorphism in osteoporosis

Zhang,

Xie,

Sun

et al. 2024

Bone Res

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Osteoporosis, a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures worldwide. Accumulating evidence has revealed that sexual dimorphism is a notable feature of osteoporosis, with sex-specific differences in epidemiology and pathogenesis. Specifically, females are more susceptible than males to osteoporosis, while males are more prone to disability or death from the disease. To date, sex chromosome abnormalities and steroid hormones have been proven to contribute greatly to sexual dimorphism in osteoporosis by regulating the functions of bone cells. Understanding the sex-specific differences in osteoporosis and its related complications is essential for improving treatment strategies tailored to women and men. This literature review focuses on the mechanisms underlying sexual dimorphism in osteoporosis, mainly in a population of aging patients, chronic glucocorticoid administration, and diabetes. Moreover, we highlight the implications of sexual dimorphism for developing therapeutics and preventive strategies and screening approaches tailored to women and men. Additionally, the challenges in translating bench research to bedside treatments and future directions to overcome these obstacles will be discussed.

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Section: Molecular Mechanisms Underlying Sexual Dimorphism In Osteopo...mentioning

confidence: 99%

Insights and implications of sexual dimorphism in osteoporosis

Zhang,

Xie,

Sun

et al. 2024

Bone Res

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“…To further quantify the frequency distribution of these keywords, the study summarized the top 20 high-frequency keywords in Table 2 . Apart from the search term gut microbiota, other popular keywords in this research field include osteoporosis ( Biver et al., 2019 ; Xu et al., 2022 ; Lyu et al., 2023 ), bone density ( Wang et al., 2023 ; Zhang et al., 2023b ), probiotics ( Jia et al., 2021 ), inflammation ( Ding et al., 2022 ; Zhu et al., 2022 ), SCFAs ( Derrien et al., 2004 ; Psichas et al., 2015 ; Whisner et al., 2016 ; Larraufie et al., 2018 ; Nath et al., 2018 ; Shetty et al., 2018 ; Keirns et al., 2020 ; Massy and Drueke, 2020 ; Mohamed et al., 2024 ; Verstraeten et al., 2024 ), metabolism ( Zhang et al., 2023a ), osteoarthritis ( Liu et al., 2022 ; Guan et al., 2023 ), calcium absorption ( Zhou et al., 2023 ), obesity ( Sato et al., 2021 ), double-blind ( Nilsson et al., 2018 ; Jansson et al., 2019 ), prebiotics ( Mohamed et al., 2024 ), mechanisms ( Zhou et al., 2023 ), postmenopausal women ( Wang et al., 2023 ), supplements ( Li et al., 2023 ), risk factors ( Chen et al., 2021 ), oxidative stress ( Li et al., 2019 ), and immune system ( Kim et al., 2017 ; Dar et al., 2018b ; Dar et al., 2018a ). Similarly to citation burst analysis, this study also conducted a burst analysis on keywords that garnered significant attention during a certain period from 2000 to 2023.…”

Section: Resultsmentioning

confidence: 99%

“…(2015) discovered that injecting acetate into the colon of wild-type mice significantly increased glucagon-like peptide-1 levels, whereby SCFAs mainly interact with G protein-coupled receptors FFAR2 and FFAR3 on enteroendocrine L cells to promote glucagon-like peptide-1 secretion. It is worth noting that an increasing body of research has found that SCFAs possess immunomodulatory functions, influencing bone metabolism through T and B cell immune mechanisms ( Keirns et al., 2020 ; Massy and Drueke, 2020 ; Mohamed et al., 2024 ). On one hand, SCFAs could significantly promote differentiation of intestinal TH17 cells and secretion of various inflammatory factors to induce osteoclastogenesis.…”

Section: Resultsmentioning

confidence: 99%

Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study

Wu,

Sun,

Guo

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionExtensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on the processes of bone formation. Nonetheless, a notable gap exists in the literature concerning a bibliometric analysis of research trends at the nexus of gastrointestinal microbiota and bone metabolism.MethodsTo address this scholarly void, the present study employs a suite of bibliometric tools including online platforms, CiteSpace and VOSviewer to scrutinize the pertinent literature in the realm of gastrointestinal microbiota and bone metabolism.Results and discussionExamination of the temporal distribution of publications spanning from 2000 to 2023 reveals a discernible upward trajectory in research output, characterized by an average annual growth rate of 19.2%. Notably, China and the United States emerge as primary contributors. Predominant among contributing institutions are Emory University, Harvard University, and the University of California. Pacifici R from Emory University contributed the most research with 15 publications. In the realm of academic journals, Nutrients emerges as the foremost publisher, followed closely by Frontiers in Microbiology and PLOS One. And PLOS One attains the highest average citations of 32.48. Analysis of highly cited papers underscores a burgeoning interest in the therapeutic potential of probiotics or probiotic blends in modulating bone metabolism by augmenting host immune responses. Notably, significant research attention has coalesced around the therapeutic interventions of probiotics, particularly Lactobacillus reuteri, in osteoporosis, as well as the role of gastrointestinal microbiota in the etiology and progression of osteoarthritis. Keyword analysis reveals prevalent terms including gut microbiota, osteoporosis, bone density, probiotics, inflammation, SCFAs, metabolism, osteoarthritis, calcium absorption, obesity, double-blind, prebiotics, mechanisms, postmenopausal women, supplementation, risk factors, oxidative stress, and immune system. Future research endeavors warrant a nuanced exploration of topics such as inflammation, obesity, SCFAs, postmenopausal osteoporosis, skeletal muscle, oxidative stress, double-blind trials, and pathogenic mechanisms. In summary, this study presents a comprehensive bibliometric analysis of global research on the interplay between gastrointestinal microbiota and bone metabolism, offering valuable insights for scholars, particularly nascent researchers, embarking on analogous investigations within this domain.

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“…The PMBG/TCP/PTH scaffold exhibited the highest migration of BMSCs (Figure 4A,B), demonstrating that PTH (1‐34) plays a role in cell recruitment. [ 15 ] ALP staining was performed on day seven to identify early‐stage bone regeneration, as ALP is a marker enzyme for early‐maturity osteoblasts ( Figure C). The results indicated that the area of ALP staining was larger in the PMBG/TCP/PTH group than in the other two groups, matching the results of the quantitative analysis of ALP activity (Figure 4D).…”

Section: Resultsmentioning

confidence: 99%

Photocurable 3D‐Printed PMBG/TCP Scaffold Coordinated with PTH (1‐34) Bidirectionally Regulates Bone Homeostasis to Accelerate Bone Regeneration

Ren

Kong

Liu

et al. 2023

Adv Healthcare Materials

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Bone defect repair remains a major clinical challenge that requires the construction of scaffolds that can regulate bone homeostasis. In this study, a photo‐cured mesoporous bioactive glass (PMBG) precursor is developed as a tricalcium phosphate (TCP) agglomerant to obtain a double‐phase PMBG/TCP scaffold via 3D printing. The scaffold exhibits multi‐scale porous structures and large surface areas, making it a suitable carrier for the loading of parathyroid hormone (PTH) (1‐34), which is used for the treatment of osteoporosis. In vitro and in vivo results demonstrate that PMBG/TCP scaffolds coordinated with PTH (1‐34) can regulate bone homeostasis in a bidirectional manner to facilitate bone formation and inhibit bone resorption. Furthermore, bidirectional regulation of bone homeostasis by PTH (1‐34) is achieved by inhibiting fibrogenic activation protein (FAP). Thus, PMBG/TCP scaffolds coordinated with PTH (1‐34) are viable materials with considerable potential for application in the field of bone regeneration and provide an excellent solution for the design and development of clinical materials.

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Gut microbiota orchestrates PTH action in bone: role of butyrate and T cells

Cited by 8 publications

References 9 publications

Insights and implications of sexual dimorphism in osteoporosis

Insights and implications of sexual dimorphism in osteoporosis

Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study

Photocurable 3D‐Printed PMBG/TCP Scaffold Coordinated with PTH (1‐34) Bidirectionally Regulates Bone Homeostasis to Accelerate Bone Regeneration

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