Gut microbiota modulation by jabuticaba peel and its effect on glucose metabolism via inflammatory signaling

Filho, Paulo Sérgio Loubet; Baseggio, Andressa Mara; Vuolo, Milena Morandi; Reguengo, Lívia Mateus; Biasoto, A. C. T.; Corrêa, L. C.; Bogusz, Stanislau; Cagnon, Valéria Helena Alves; Cazarin, Cínthia Baú Betim; Júnior, Mário Roberto Maróstica

doi:10.1016/j.crfs.2022.02.001

Cited by 21 publications

(14 citation statements)

References 61 publications

(76 reference statements)

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“…We speculate that this may be a characteristic of the feed (which only causes NAFLD without changing the diversity of the mice’s intestinal flora). Which is different from previous studies, and the exact reason needs to be verified in subsequent supplementary experiments ( 55 , 56 ). After gavage of camel milk, cow milk, and silymarin to mice, the Ace index and Chao index in the Alpha diversity of intestinal flora of mice in CaM and PC groups were significantly higher ( p < 0.05), but the Ace index and Chao index of mice in CoM group were not significantly different from Mod group ( p > 0.05), indicating that camel milk and silymarin could increase the number of species and the relative abundance of intestinal flora of mice.…”

Section: Discussioncontrasting

confidence: 75%

Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease

Hao

Liang

et al. 2022

Front. Nutr.

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Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease of life, usually caused by unhealthy diet and lifestyle. Compared to normal individuals, the structure of the intestinal flora of NAFLD patients is altered accordingly. This study investigates the effect of camel milk on the regulation of intestinal flora structure in mice with high-fat diet-induced NAFLD. NAFLD model was established by feeding C57BL/6J mice a high-fat diet for 12 weeks, meanwhile camel milk (3.0 g/kg/d), cow milk (3.0 g/kg/d), and silymarin (200 mg/kg/d) were administered by gavage, respectively. Food intake and changes of physiological indexes in mice were observed and recorded. The 16S rRNA gene V3-V4 region was sequenced and the intestinal flora diversity and gene function were predicted in the colon contents of mice from different group. The results showed that camel milk enhanced glucolipid metabolism by downregulate the levels of blood glucose and triglyceride (TG) in serum, reduced lipid accumulation by downregulate the level of TG in the liver and improved liver tissue structure in NAFLD mice (p < 0.05). Meanwhile, camel milk had a positive modulatory effect on the intestinal flora of NAFLD mice, increasing the relative abundance of beneficial bacteria and decreasing the relative abundance of harmful bacteria in the intestinal flora of NAFLD mice, and silymarin had a similar modulatory effect. At the genus level, camel milk increased the relative abundance of Bacteroides, norank_f_Muribaculaceae and Alloprevotella and decreased the relative abundance of Dubosiella and Coriobacteriaceae_UCG-002 (p < 0.05). Camel milk also enhanced Carbohydrate metabolism, Amino acid metabolism, Energy metabolism, Metabolism of cofactors and vitamins and Lipid metabolism in NAFLD mice, thus reducing the degree of hepatic lipid accumulation in NAFLD mice and maintaining the normal structure of the liver. In conclusion, camel milk can improve the structure and diversity of intestinal flora and enhance the levels of substance and energy metabolism in NAFLD mice, which has a positive effect on alleviating NAFLD and improving the structure of intestinal flora.

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Section: Discussioncontrasting

confidence: 75%

Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease

Hao

Liang

et al. 2022

Front. Nutr.

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“…Compared with PN group, taking SePN increased the relative abundance of Muribaculaceae, Rikenellaceae, Erysipelotrichaceae ( Supplementary Figure S1 ). At present, studies showed that the increase in the abundance of these microorganisms is negatively correlated with the risk of disease induced by HFD ( 49 – 52 ). Interestingly, some studies showed that dietary selenium supplementation can improve their relative abundance ( 53 , 54 ).…”

Section: Discussionmentioning

confidence: 99%

Feeding foliar nano-selenium biofortified panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets

Dong

Yan

et al. 2022

Front. Nutr.

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Nano-selenium (nano-Se) has been extensively explored as a biostimulant for improving the quality of grain crops. However, there are few reports about the effect on the medicinal components of Chinese herbal medicine cultured with nano-Se. Here, we sprayed nano-Se during the cultivation of Panax notoginseng (SePN), and measured the changes of medicinal components compared with conventional Panax notoginseng (PN). Furthermore, we identified a more pronounced effect of SePN on reducing obesity in animals compared with PN. By measuring antioxidant capacity, histopathology, gene expression related to glycolipid metabolism, and gut microbiota composition, we propose a potential mechanism for SePN to improve animal health. Compared with the control groups, foliar spraying of nano-Se increased saponins contents (Rb2, Rb3, Rc, F2, Rb2, and Rf) in the roots of Panax notoginseng, the content of Rb2 increased by 3.9 times particularly. Interestingly, animal studies indicated that taking selenium-rich Panax notoginseng (SePN) can further ameliorate liver antioxidation (SOD, MDA, and GSH) and enzyme activities involved in glycolipid metabolism (ATGL and PFK). It also relieved inflammation and regulated the expression of genes (MCAD, PPAR-α, and PCSK9) related to fatty acid oxidation. The abundance ratio of Firmicutes/Bacteroides and beneficial bacteria abundance (Bifidobacterium, Butyricimonas, and Parasutterella) in gut microbiota were improved relative to the control. In summary, the application of nano-Se on PN may effectively raise the content of Panax notoginseng saponins (PNS) and immensely lower the risk of metabolic disorders of glycolipids.

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“…Currently, an unambiguous association between Saccharimonadaceae abundance in the colon microbiota and health status was not identified. Consumption of dietary supplements enriched with natural antioxidants or polysaccharides [ 81 , 82 , 83 , 84 ], probiotic strain Lactiplantibacillus plantarum-12 [ 85 ], or fecal microbiota transplantation in dysbiotic animals [ 85 ] elevates the abundance of Saccharimonadaceae. Conversely, the abundance of Saccharimonadaceae decreases in the obese rat [ 82 , 86 ] and was negatively correlated with non-alcoholic fatty liver disease scores in model conditions [ 87 ].…”

Section: Discussionmentioning

confidence: 99%

“…Consumption of dietary supplements enriched with natural antioxidants or polysaccharides [ 81 , 82 , 83 , 84 ], probiotic strain Lactiplantibacillus plantarum-12 [ 85 ], or fecal microbiota transplantation in dysbiotic animals [ 85 ] elevates the abundance of Saccharimonadaceae. Conversely, the abundance of Saccharimonadaceae decreases in the obese rat [ 82 , 86 ] and was negatively correlated with non-alcoholic fatty liver disease scores in model conditions [ 87 ]. In humans, a high intake of dietary saturated fatty acids led to the depletion of Saccharimonadaceae in the gut microbiota [ 88 ].…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats

et al. 2022

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Trace amine-associated receptors (TAAR1-TAAR9) are a family of G-protein-coupled monoaminergic receptors which might have great pharmacological potential. It has now been well established that TAAR1 plays an important role in the central nervous system. Interestingly, deletion of TAAR9 in rats leads to alterations in the periphery. Previously, we found that knockout of TAAR9 in rats (TAAR9-KO rats) decreased low-density lipoprotein cholesterol levels in the blood. TAAR9 was also identified in intestinal tissues, and it is known that it responds to polyamines. To elucidate the role of TAAR9 in the intestinal epithelium, we analyzed TAAR9-co-expressed gene clusters in public data for cecum samples. As identified by gene ontology enrichment analysis, in the intestine, TAAR9 is co-expressed with genes involved in intestinal mucosa homeostasis and function, including cell organization, differentiation, and death. Additionally, TAAR9 was co-expressed with genes implicated in dopamine signaling, which may suggest a role for this receptor in the regulation of peripheral dopaminergic transmission. To further investigate how TAAR9 might be involved in colonic mucosal homeostasis, we analyzed the fecal microbiome composition in TAAR9-KO rats and their wild-type littermates. We identified a significant difference in the number of observed taxa between the microbiome of TAAR9-KO and wild-type rats. In TAAR9-KO rats, the gut microbial community became more variable compared with the wild-type rats. Furthermore, it was found that the family Saccharimonadaceae, which is one of the top 10 most abundant families in TAAR9-KO rat feces, is almost completely absent in wild-type animal fecal samples. Taken together, these data indicate a role of TAAR9 in intestinal function.

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Gut microbiota modulation by jabuticaba peel and its effect on glucose metabolism via inflammatory signaling

Cited by 21 publications

References 61 publications

Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease

Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease

Feeding foliar nano-selenium biofortified panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets

Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats

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