Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation

Wang, Zhong; Chen, Wen‐Hao; Li, Suxia; He, Zhongming; Zhu, Weili; Ji, Yin; Wang, Zhe; Zhu, Xianyang; Yuan, Kai; Bao, Yanping; Shi, Le; Meng, Shi-Qiu; Xue, Yan-Xue; Xie, Wen; Shi, Jie; Yan, Wei; Wei, Hong; Lü, Lin; Han, Ying

doi:10.1038/s41380-021-01113-1

Cited by 140 publications

(122 citation statements)

References 85 publications

Supporting

Mentioning

113

Contrasting

Order By: Relevance

“…Gut symbiotic microorganisms are essential in the dynamic interaction between brain and gut ( 11 , 12 ). Gut microbiota can affect numerous physiological pathways of the host, including nutrient metabolism, immune function, and the production of neurotransmitters as well as hormones ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus Ameliorates SD-Induced Stress Responses and Gut Dysbiosis by Increasing the Absorption of Gut-Derived GABA in Rhesus Monkeys

Zhao

Jian

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Sleep deprivation (SD) has become a health problem in the modern society. Although probiotics supplementation has been proven to improve SD-induced gut dysbiosis, the potential neuroendocrine mechanisms remain elusive. In this study, thirty rhesus monkeys (RMs) were recruited. Paradoxical sleep, bright light, and noise were used to build an RM SD model. We examined the plasma γ-aminobutyric acid (GABA), stress hormones, and inflammatory cytokines using ELISAs. 16S ribosomal DNA sequencing and untargeted metabolomics sequencing were employed to detect gut microbial community and metabolites, respectively. The results of our study showed that RMs subjected to SD had elevated plasma stress hormones (such as cortisol and norepinephrine) and proinflammatory cytokines (such as TNF-α, IL-6, and IL-8), and a decreased anti‐inflammatory cytokine IL-10 level. Additionally, SD could give rise to a significant change in gut microbiota and metabolites. The differential gut microbiota and metabolites caused by SD were enriched in the signaling pathways related to GABA metabolism. Pearson correlation analysis revealed that there is a significant correlation between plasma GABA and SD-induced stress responses and gut dysbiosis. The supplementation of GABA-producing probiotics could significantly increase the relative abundance of Lactobacillus and plasma GABA levels, and reverse SD‐induced stress responses and gut dysbiosis. Therefore, we speculated that SD-induced stress response and gut dysbiosis might be an outcome of reduced gut-derived GABA absorption. The supplementation of GABA-producing Lactobacillus might be beneficial for the treatment of SD-induced intestinal dysfunction.

show abstract

Section: Introductionmentioning

confidence: 99%

Lactobacillus Ameliorates SD-Induced Stress Responses and Gut Dysbiosis by Increasing the Absorption of Gut-Derived GABA in Rhesus Monkeys

Zhao

Jian

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Given that gut microbiota could regulate the immune system and contributes to neuroinflammation, we investigated whether microbiota dysbiosis was associated with host emotional deficits after anesthesia/surgery in rats with preoperative stress ( 22 , 23 ). The principal component analysis (PCA) revealed a remarkable difference in the gut microbiota composition between CC rats and SS rats ( Figure 3A ).…”

Section: Resultsmentioning

confidence: 99%

Gut microbiota-mediated metabolic restructuring aggravates emotional deficits after anesthesia/surgery in rats with preoperative stress

Lei

Ji²,

Yang³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Patients with preoperative stress are prone to postoperative emotional deficits. However, the underlying mechanisms are largely unknown. Here, we characterize the changes of microbial composition and specific metabolites after anesthesia/surgery in rats with preoperative stress based on 16S rRNA gene sequencing and non-targeted metabolomics technique. Consequently, we found that anesthesia/surgery aggravated anxiety-like and depression-like behaviors in rats under preoperative stress. Microglia were activated and pro-inflammatory cytokines, including interleukin 6 (IL-6) and tumor necrosis factor ɑ (TNF-α) were upregulated after anesthesia/surgery. The postoperative gut microbiota and metabolite composition of rats exposed to preoperative stress differed from those of control rats. Lastly, emotional impairments, metabolic alterations, and neuroinflammation returned normal in antibiotics-treated rats. Our findings provide further evidence that abnormalities in the gut microbiota contribute to postoperative metabolic restructuring, neuroinflammation, and psychiatric deficits in rats under preoperative stress.

show abstract

“…Our initial aim will be to survey which sleep disruption models have been used in preclinical research including mechanical sleep disruption [ 47 ], paradoxical sleep disruption [ 49 ], circadian light alteration sleep disruption [ 58 ], and biological sleep disruption [ 60 ] in gut microbiome research. We will also identify the extent that sleep disruption interventions have been used in human gut microbiome studies including sleep deprivation [ 63 ] and sleep restriction [ 51 ], and what pathological sleep conditions have been explored in the context of the microbiome. We hypothesize that sleep disruption will be associated with disruptions in global diversity measures and changes in specific bacterial taxa and metabolic genes, but these results will vary based on the microbiome analysis metric and sleep disruption model.…”

Section: Discussionmentioning

confidence: 99%

Examining the Relationships Between Sleep Physiology and the Gut Microbiome in Preclinical and Translational Research: Protocol for a Scoping Review

Maki¹,

Alkhatib²,

Butera³

et al. 2022

JMIR Res Protoc

View full text Add to dashboard Cite

Background Sleep is an instrumental behavioral state with evidence supporting its active role in brain function, metabolism, immune function, and cardiovascular systems. Research supports that there are pathways underlying the bidirectional communication between the brain and gastrointestinal system, also known as the “gut-brain axis.” Primary research examining sleep and gut microbiome relationships continues to increase. Although current data include both preclinical and clinical research, gut microbiome results are reported through a wide range of metrics (alpha diversity, beta diversity, and bacterial compositional changes), which makes cross-study comparison challenging. Therefore, a synthesis of the research examining sleep and gut microbiome relationships is necessary to understand the state of the science and address gaps in the literature for future research. Objective In this paper, we outline a scoping review protocol to evaluate and synthesize preclinical and clinical primary research focused on the associations between sleep and the gut microbiome. Methods The search strategy was facilitated through a medical research librarian and involved electronic databases including PubMed/MEDLINE, Embase, Scopus, Web of Science, CENTRAL trials database, BIOSIS Citation Index, and the Zoological Record. Gray literature sources including medRxiv and bioRxiv preprint servers were also searched. Studies were screened according to the aims and exclusion and inclusion criteria of the protocol. After screening, data will be extracted and synthesized from the included studies according to predefined sleep and microbiome methodology metrics. Results The search strategy yielded 4622 references that were imported for study screening, and source screening was completed in May 2022 by 2 independent investigators, resulting in a total of 93 sources for data extraction and synthesis. The data synthesis table is expected to be completed by August 2022, and the results will be disseminated through paper submission by December 2022 and presented at conferences related to neuroscience, sleep physiology, bioinformatics, and the microbiome. Conclusions A scoping review of preclinical and clinical research is needed to synthesize the growing data focused on the relationships between sleep and the gut microbiome. We expect the results of this synthesis will identify gaps in the literature and highlight pathways linking the gut-brain axis and sleep physiology to stimulate future research questions. Trial Registration Open Science Framework 69TBR; https://osf.io/69tbr International Registered Report Identifier (IRRID) PRR1-10.2196/38605

show abstract

Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation

Cited by 140 publications

References 85 publications

Lactobacillus Ameliorates SD-Induced Stress Responses and Gut Dysbiosis by Increasing the Absorption of Gut-Derived GABA in Rhesus Monkeys

Lactobacillus Ameliorates SD-Induced Stress Responses and Gut Dysbiosis by Increasing the Absorption of Gut-Derived GABA in Rhesus Monkeys

Gut microbiota-mediated metabolic restructuring aggravates emotional deficits after anesthesia/surgery in rats with preoperative stress

Examining the Relationships Between Sleep Physiology and the Gut Microbiome in Preclinical and Translational Research: Protocol for a Scoping Review

Contact Info

Product

Resources

About