Gut microbiota modulates osteoclast glutathione synthesis and mitochondrial biogenesis in mice subjected to ovariectomy

Abstract

Osteoporosis is one of the most common bone diseases in the clinic and is mainly caused by a decrease in oestrogen. 1,2 The disability, mortality and cost of hip and vertebral fractures are substantial in osteoporosis patients. 3 Therefore, it is a major public health concern to prevent osteoporosis.Trillions of microbes inhabit the intestine, and these microbes together are referred to as the gut microbiota. The gut microbiota has a profound influence on its host, including regulation

Chemotherapeutic Drugs Induce Different Gut Microbiota Disorder Pattern and NOD/RIP2/NF-κB Signaling Pathway Activation That Lead to Different Degrees of Intestinal Injury

“…Epsilonbacteraeota decreased significantly, while Verrucomicrobia and Deferribacteres increased significantly in CPT-11 and L-OHP groups ( P < 0.05 versus control). The Firmicutes/Bacteroidetes (F/B) ratio is used as a common parameter to assess the gut microbiota disorder in many diseases ( 22 ). As shown in Fig.…”

Spotlight on the Gut Microbiome in Menopause: Current Insights

“…(4) Finally, are menopause-related health sequelae mediated by the gut microbiome? Animal models suggest a causal role of the gut microbiome in potentiating disease states induced by ovariectomy, including metabolic syndrome, 73 non-alcoholic fatty liver disease, 85 osteoporosis, 86 , 87 and atherosclerosis. 74 For example, enhanced microbial translocation due to ovariectomy has been shown to induce bone loss in mice, and a less diverse and altered gut microbiome 88 , 89 and higher gut permeability 62 have been associated with lower bone mineral density in studies of post-menopausal women.…”

A narrative review of the moderating effects and repercussion of exercise intervention on osteoporosis: ingenious involvement of gut microbiota and its metabolites

“…In addition to acting as a scaffold for body, it also continuously communicates with other organs through the biochemical signals, and has basic neural, immune and endocrine regulatory functions [85,86]. The GM and its metabolites are associated with a variety of diseases in musculoskeletal system, including the sarcopenia, osteoarthritis, ankylosing spondylitis, OP, and rheumatoid arthritis [87][88][89][90][91]. The GM is involved in regulating the balance of musculoskeletal development and homeostasis, and related researches have also shifted from describing simple correlations to seeking intervention mechanisms through the basic researches and clinical trials, which has made this field develop rapidly in recent years [92,93].…”