Gut Microbiota-Mediated Immunomodulatory Effects of<i>Lactobacillus rhamnosus</i>HDB1258 Cultured in the Lava Seawater in the Colitis Mouse Model

Kim, Kyung Min; Song, Ji‐Won; Yang, Seung Won; Choi, Ji-Whi; Sohn, Jungwoo; Han, Sang-Kap; Shin, Yoon-Jung; Lee, Dong-Yeon; Lee, Seunghun; Kim, Dong-Hyun

doi:10.1089/jmf.2021.k.0103

Cited by 2 publications

(1 citation statement)

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“…However, it is essential to note that our study did not reveal a significant immunomodulatory effect of LM1019 on this cell line, which contradicts findings for other strains within the same species [ 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ]. Previous research has highlighted the strain-specific effects of probiotics on immune function.…”

Section: Discussioncontrasting

confidence: 99%

Immune-Stimulating Potential of Lacticaseibacillus rhamnosus LM1019 in RAW 264.7 Cells and Immunosuppressed Mice Induced by Cyclophosphamide

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Kim,

Kim

et al. 2023

Microorganisms

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Probiotics, including Lacticaseibacillus rhamnosus (L. rhamnosus), have gained recognition for their potential health benefits, such as enhancing immune function, maintaining gut health, and improving nutrient absorption. This study investigated the effectiveness of L. rhamnosus LM1019 (LM1019) in enhancing immune function. In RAW 264.7 cells, LM1019 demonstrated dose-dependent immune stimulation by increasing nitric oxide production, gene expression of proinflammatory cytokines, and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These effects were mediated through the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) translocation without inducing cytotoxicity. Furthermore, orally administered LM1019 was evaluated in immunosuppressed mice induced by cyclophosphamide (CTX). High-dose administration of LM1019 significantly increased the subpopulations of lymphocytes, specifically helper T cells (CD4+), as well as two subtypes of natural killer (NK) cells, namely, IFN-γ+ and granzyme B+ NK cells. Additionally, LM1019 at a high dose led to elevated levels of proinflammatory cytokines, including IFN-γ and IL-12, compared to CTX-treated mice. These findings highlight the potential of LM1019 in enhancing the immune system. The study contributes to the growing body of research on the beneficial effects of probiotics on immune function.

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