Gut microbiota involved in spermatogenic function of Sancai Lianmei granules in obese mice

Co-Housing and Fecal Microbiota Transplantation: Technical Support for TCM Herbal Treatment of Extra-Intestinal Diseases Based on Gut Microbial Ecosystem Remodeling

“… Hao et al 114 Metabolic system Obesity FMT on the obese mice induced by high-fat diet Normal diet mice gavaged with Sancai Lianmei granules Male C57BL/6 mouse Oral gavage Reduced the blood glucose level and body weight; Improved the levels of blood lipid parameters. Xia et al 115 Metabolic system Obesity FMT on the obese mice induced by high-fat diet Salidroside-treated HFD-fed mice Male C57BL/6J mouse Oral gavage Decreased weight gain and fat accumulation. Liu et al 116 Metabolic system Type 1 diabetes mellitus Patient 1: Received three FMT through one nasal tube injection and two oral capsules, respectively.…”

“… Reduced the blood glucose level and body weight; Improved the levels of blood lipid parameters (TC ↓, HDL ↓, LDL ↓); Regulated the expression of oxidative stress products (MDA ↓, 8-OHdG ↓); Improved the spermatogenic functions (sperm density ↑, sperm viability ↑, inflammatory responses ↓, excessive cellular autophagy ↓). Xia et al 115 Linggui Zhugan Decoction Obesity Male C57BL/6 mouse Caloric restriction + LZD-treated mice Obese mice induced by high-fat diet FMT (Oral gavage, 200μL, Once every three days for 16 weeks) Altered the key bacterial communities: ① Regulated the abundance of metabolic syndrome-related bacteria (Bacteroides coprophilus ↑); ② Regulated the abundance of butyrate-producing bacteria (Thermotogae ↑, Alistipes putredinis ↑). Attenuates diet-induced obesity and hepatosteatosis (body weight ↓, blood glucose level ↓, plasma TG and TC levels ↓, hepatic lipid staining ↓, hepatic TG and TC levels ↓, OCR ↑, RQ ↓); Suppressed lipid biosynthesis in the liver (regulated the hepatic expression of lipogenic genes: SREBP-1c ↓, ACCα ↓, FASN ↓, SCD-1 ↓, PPARγ ↓).…”