Gut microbiota in overweight and obesity: crosstalk with adipose tissue

Cani, Patrice D.; Van Hul, Matthias

doi:10.1038/s41575-023-00867-z

Cited by 11 publications

(1 citation statement)

References 278 publications

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“…Adipose tissues are divided into WAT and brown adipose tissue (BAT) and usually perform opposite physiological functions [ 60 ]. The primary function of WAT is to store surplus energy in the form of triglycerides and aid in energy accumulation, while BAT acts mainly to produce heat to combat obesity and cold and contribute to energy dissipation [ 61 ]. The induction of brown adipocytes within depots of WAT is referred to as WAT browning.…”

Section: Cancer Cell-derived Exosomes Promote the Formation Of Cancer...mentioning

confidence: 99%

Exosomes in the pathogenesis and treatment of cancer-related cachexia

Ru,

Chen,

et al. 2024

J Transl Med

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Cancer-related cachexia is a metabolic syndrome characterized by weight loss, adipose tissue decomposition, and progressive skeletal muscle atrophy. It is a major complication of many advanced cancers and seriously affects the quality of life and survival of cancer patients. However, the specific molecules that mediate cancer-related cachexia remain elusive, and the fundamental cellular and molecular mechanisms associated with muscle atrophy and lipidolysis in cancer patients still need to be investigated. Exosomes, a newly discovered class of small extracellular vesicles that facilitate intercellular communication, have a significant role in the onset and development of various cancers. Studies have shown that exosomes play a role in the onset and progression of cancer-related cachexia by transporting active molecules such as nucleic acids and proteins. This review aimed to provide an overview of exosome developments in cancer-induced skeletal muscle atrophy and adipose tissue degradation. More importantly, exosomes were shown to have potential as diagnostic markers or therapeutic strategies for cachexia and were prospected, providing novel strategies for the diagnosis and treatment of cancer-related cachexia.

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Section: Cancer Cell-derived Exosomes Promote the Formation Of Cancer...mentioning

confidence: 99%