2022
DOI: 10.3390/nu14245323
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Gut Microbiota in Non-Alcoholic Fatty Liver Disease Patients with Inflammatory Bowel Diseases: A Complex Interplay

Abstract: The intestinal microbiota represents the microbial community that colonizes the gastrointestinal tract and constitutes the most complex ecosystem present in nature. The main intestinal microbial phyla are Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, Fusobacteria, and Verrucromicrobia, with a clear predominance of the two phyla Firmicutes and Bacteroidetes which account for about 90% of the intestinal phyla. Intestinal microbiota alteration, or dysbiosis, has been proven to be involved in the deve… Show more

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Cited by 21 publications
(19 citation statements)
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References 58 publications
(60 reference statements)
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“…The microbiota of the intestines encompasses the microbial community inhabiting the GI tract, with an estimated presence of more than 100 trillion microorganisms 29. Colonisation begins at birth, matures over time, and is affected by various dietary, environmental, and genetic factors 30. In a healthy patient, the host and bacterial colonisers within the microbiota display a delicate symbiotic homeostasis.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The microbiota of the intestines encompasses the microbial community inhabiting the GI tract, with an estimated presence of more than 100 trillion microorganisms 29. Colonisation begins at birth, matures over time, and is affected by various dietary, environmental, and genetic factors 30. In a healthy patient, the host and bacterial colonisers within the microbiota display a delicate symbiotic homeostasis.…”
Section: Discussionmentioning
confidence: 99%
“…Changes in the microbiota have also been noted in patients with MAFLD. The gut microbiome’s main intestinal phyla are Firmicutes and Bacteroidetes , which amass more than 90% of the entire microorganism population 30. A disruption in population sizes and ratios may contribute to the pathological effects seen in MAFLD.…”
Section: Discussionmentioning
confidence: 99%
“…The study by Abenavoli et al (2022) aimed to shed light on the complex interplay between gut microbiota and two increasingly prevalent diseases, NAFLD and IBD [9]. It is worth mentioning that NAFLD encompasses a range of conditions, ranging from simple fatty liver to NASH, which can eventually lead to liver cirrhosis and hepatocellular carcinoma [10].…”
Section: Discussionmentioning
confidence: 99%
“…Despite numerous studies supporting a positive association between IBD and NAFLD, a clear and well-established common pathogenesis has yet to be determined, although several emerging hypotheses exist [15]. In effect, they point to a potential interplay between factors such as increased intestinal permeability, changes in gut microbiota, endotoxemia, oxidative stress-induced inflammation, and genetic susceptibility [9,16]. Herein, the overproduction of conjugated bile acids due to gut dysbiosis may contribute to the development of NAFLD when they are returned to the liver [17].…”
Section: Discussionmentioning
confidence: 99%
“…Although the pathogenetic link between gut microbiota and NAFLD has been widely investigated [ 27 , 28 ], its relationship with MAFLD is poorly known. It is well known that MAFLD is a “multiple-hit” disease, which has obesity, diabetes, insulin resistance, genetic and environmental factors, and a dysbiosis of the gut microbiota as risk factors [ 29 ], as shown in Figure 3 .…”
Section: Mafld and Gut Microbiota: Possible Pathogenetic Waysmentioning
confidence: 99%