Gut Microbiota in Metabolic-associated Fatty Liver Disease and in Other Chronic Metabolic Diseases

Hernández-Ceballos, Winston; Córdova-Gallardo, Jacqueline; Méndez-Sánchez, Nahúm

doi:10.14218/jcth.2020.00131

Cited by 20 publications

(24 citation statements)

References 97 publications

(207 reference statements)

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“…During the last years, a substantial number of studies on the impact of gut microbiota and host health have been conducted, showing that the disruption of gut microbiota homeostasis (called dysbiosis) is related to a large array of diseases. These include metabolic diseases like obesity and metabolic-associated fatty liver disease [ 7 , 8 ], irritable bowel syndrome [ 9 ] as well as several immune-related diseases like allergies [ 10 ], autoimmune diseases [ 11 ], and inflammatory bowel disease [ 12 ]. These latter associations illustrate the direct interaction between gut microbiota and the immune system.…”

Section: Gut Microbiota and Immune Systemmentioning

confidence: 99%

The Immune System through the Lens of Alcohol Intake and Gut Microbiota

Calleja‐Conde

Echeverry‐Alzate

Bühler

et al. 2021

IJMS

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The human gut is the largest organ with immune function in our body, responsible for regulating the homeostasis of the intestinal barrier. A diverse, complex and dynamic population of microorganisms, called microbiota, which exert a significant impact on the host during homeostasis and disease, supports this role. In fact, intestinal bacteria maintain immune and metabolic homeostasis, protecting our organism against pathogens. The development of numerous inflammatory disorders and infections has been linked to altered gut bacterial composition or dysbiosis. Multiple factors contribute to the establishment of the human gut microbiota. For instance, diet is considered as one of the many drivers in shaping the gut microbiota across the lifetime. By contrast, alcohol is one of the many factors that disrupt the proper functioning of the gut, leading to a disruption of the intestinal barrier integrity that increases the permeability of the mucosa, with the final result of a disrupted mucosal immunity. This damage to the permeability of the intestinal membrane allows bacteria and their components to enter the blood tissue, reaching other organs such as the liver or the brain. Although chronic heavy drinking has harmful effects on the immune system cells at the systemic level, this review focuses on the effect produced on gut, brain and liver, because of their significance in the link between alcohol consumption, gut microbiota and the immune system.

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Section: Gut Microbiota and Immune Systemmentioning

confidence: 99%

The Immune System through the Lens of Alcohol Intake and Gut Microbiota

Calleja‐Conde

Echeverry‐Alzate

Bühler

et al. 2021

IJMS

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“…Alterations in the composition of the gut flora alter host–microbiota interactions and lead to the dysregulation of the gut immune system, which is associated with the pathogenesis of several diseases, including type 2 DM, obesity, and MAFLD [ 21 ]. The gut microbiota primarily affects the host through immunological, metabolic-dependent, and metabolic-independent pathways [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Adults with Metabolic Dysfunction-Associated Fatty Liver Disease

Hwang

Han

2021

IJERPH

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The aims of this study were as follows: to investigate the association between metabolic dysfunction-associated fatty liver disease (MAFLD) and health-related quality of life (HRQoL), to evaluate whether stress perception and mental health among patients with MAFLD affect HRQoL, and to identify the underrated burden on MAFLD patients. Nationwide data from the 5th Korean National Health and Nutrition Examination Survey (KNHANES V, 2010 to 2012) were used. MAFLD was defined by a fatty liver index (FLI) of ≥60, and the EuroQol-5D (EQ-5D) was used to assess HRQoL. Logistic regression analysis and odds ratios (ORs) were used to determine the associations of MAFLD with stress, mental health, and HRQoL. Previous suicidal impulse was not found to be significantly associated with HRQoL. The risk of MAFLD increased 1.265-fold with an increase in stress levels based on the stress perception rate (confidence index (CI): 1.046–1.530; p < 0.05), while it increased 1.091-fold with a 1-point decrease in the EQ-5D score (CI: 1.019–1.169; p < 0.05). HRQoL impairment and stress levels are associated with MAFLD. It is important to evaluate stress levels among MAFLD patients and implement stress management and HRQoL improvement strategies.

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“…Several potentially beneficial anaerobic commensal bacteria, such as Faecalibacterium prausnitzii , Akkermansia muciniphila , and Rosburia intestinalis , have been found to be enriched after bariatric surgery 38 . Family members share similar microbial signatures, and it is thought that the composition of the gut microbiota is at least partly influenced by genetics 37 . Furthermore, small intestinal bacterial overgrowth, increased gut permeability, and gut-derived metabolites are related to the development of NAFLD/MAFLD 2,39 …”

Section: Pathophysiology Of Nafld/mafldmentioning

confidence: 99%

“…38 Family members share similar microbial signatures, and it is thought that the composition of the gut microbiota is at least partly influenced by genetics. 37 Furthermore, small intestinal bacterial overgrowth, increased gut permeability, and gut-derived metabolites are related to the development of NAFLD/MAFLD. 2,39…”

Section: Gut Microbiotamentioning

confidence: 99%

Renaming NAFLD to MAFLD: Advantages and Potential Changes in Diagnosis, Pathophysiology, Treatment, and Management

Rui

Yang

et al. 2022

Infectious Microbes and Diseases

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In recent years, with the increasing incidence of obesity and other metabolic diseases, the prevalence of non-alcoholic fatty liver disease (NAFLD) has increased and it has become a major health problem affecting more than one quarter of the world's population. Recently, experts reached a consensus that NAFLD does not reflect the current knowledge, and metabolic dysfunction-associated fatty liver disease (MAFLD) was suggested as a more appropriate term. MAFLD is not just a simple renaming of NAFLD. The definition of MAFLD allows a patient to have dual (or more) etiologies for their liver disease, which will help to exclude more heterogeneous patients. In this review, we introduce the significant differences between the definitions of NAFLD and MAFLD. In addition, we also describe the advantages of the term MAFLD in the pathophysiology, therapy, and patient management.

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Gut Microbiota in Metabolic-associated Fatty Liver Disease and in Other Chronic Metabolic Diseases

Cited by 20 publications

References 97 publications

The Immune System through the Lens of Alcohol Intake and Gut Microbiota

The Immune System through the Lens of Alcohol Intake and Gut Microbiota

Quality of Life in Adults with Metabolic Dysfunction-Associated Fatty Liver Disease

Renaming NAFLD to MAFLD: Advantages and Potential Changes in Diagnosis, Pathophysiology, Treatment, and Management

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