Gut microbiota in mental health and depression: role of pre/pro/synbiotics in their modulation

Methiwala, Hasnain N; Vaidya, Bhupesh; Addanki, Vamsi Krishna; Bishnoi, Mahendra; Sharma, Shyam Sunder; Kondepudi, Kanthi Kiran

doi:10.1039/d0fo02855j

Cited by 23 publications

(15 citation statements)

References 269 publications

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“…Free fatty acid receptor 2 is expressed on enteroendocrine cells and is known to bind SCFAs [11,57]. Importantly, free fatty acid receptor activation stimulates the release of glucagon-like peptide-1 and peptide YY into the blood stream, which regulate post-prandial release of insulin and satiety, respectively [84]. Chronic stress is also known to decrease GLP-1 levels in the paraventricular nucleus of the hypothalamus, dysregulating eating behaviour [85].…”

Section: Intestinal Barrier Integrity Pathwaysmentioning

confidence: 99%

The Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression

Herselman

Bailey

Bobrovskaya

2022

IJMS

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Compelling evidence is building for the involvement of the complex, bidirectional communication axis between the gastrointestinal tract and the brain in neuropsychiatric disorders such as depression. With depression projected to be the number one health concern by 2030 and its pathophysiology yet to be fully elucidated, a comprehensive understanding of the interactions between environmental factors, such as stress and diet, with the neurobiology of depression is needed. In this review, the latest research on the effects of stress on the bidirectional connections between the brain and the gut across the most widely used animal models of stress and depression is summarised, followed by comparisons of the diversity and composition of the gut microbiota across animal models of stress and depression with possible implications for the gut–brain axis and the impact of dietary changes on these. The composition of the gut microbiota was consistently altered across the animal models investigated, although differences between each of the studies and models existed. Chronic stressors appeared to have negative effects on both brain and gut health, while supplementation with prebiotics and/or probiotics show promise in alleviating depression pathophysiology.

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Section: Intestinal Barrier Integrity Pathwaysmentioning

confidence: 99%

The Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression

Herselman

Bailey

Bobrovskaya

2022

IJMS

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“…In terms of how to control the intestinal microbiota in our daily lives, moderate exercise is suggested to have beneficial effects on health, such as reducing inflammation and intestinal permeability and improving the body composition [ 8 ]. In addition, mental health initiatives such as stress reduction and improvement of the oral environment are also effective in preserving the intestinal environment [ 9 , 10 ]. As the concept of preventive medicine grows in importance, this assertion will gain more credibility.…”

Section: Introductionmentioning

confidence: 99%

Role of Microbiota in Viral Infections and Pathological Progression

Mizutani

Ishizaka

Koga

et al. 2022

Viruses

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Viral infections are influenced by various microorganisms in the environment surrounding the target tissue, and the correlation between the type and balance of commensal microbiota is the key to establishment of the infection and pathogenicity. Some commensal microorganisms are known to resist or promote viral infection, while others are involved in pathogenicity. It is also becoming evident that the profile of the commensal microbiota under normal conditions influences the progression of viral diseases. Thus, to understand the pathogenesis underlying viral infections, it is important to elucidate the interactions among viruses, target tissues, and the surrounding environment, including the commensal microbiota, which should have different relationships with each virus. In this review, we outline the role of microorganisms in viral infections. Particularly, we focus on gaining an in-depth understanding of the correlations among viral infections, target tissues, and the surrounding environment, including the commensal microbiota and the gut virome, and discussing the impact of changes in the microbiota (dysbiosis) on the pathological progression of viral infections.

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“…The elevation in the aggressive peck negatively correlates with the nonaggressive pecks, e.g., for playing [ 55 ]. It may underline the previous findings that the early life adverse impacts can be buffered and masked by the favorable experience at a later age, such as the environmental enrichment or social support from other birds [ 56 ].…”

Section: Discussionmentioning

confidence: 74%

“…Imbalance of gut microbiota is associated with neuroinflammation and psychiatric disorders in humans and various experimental animals [ 19 , 20 ]. Modulation of gut microbiota using prebiotics, probiotics, and synbiotics to regulate the MGB axis has been used as an alternative to antidepressant therapy in humans [ 56 ]. In the current study, the reprogrammed MGB axis was found along with the decreased BW and aggression.…”

Section: Discussionmentioning

confidence: 99%

Embryonic Exposure to Tryptophan Yields Bullying Victimization via Reprogramming the Microbiota-Gut-Brain Axis in a Chicken Model

Huang

Peng

et al. 2022

Nutrients

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Maternal metabolic disorder during early pregnancy may give rise to emotional and behavioral disorders in the child, vulnerable to bullying. Placental tryptophan fluctuation consequently disrupts offspring gut microbiome and brain neurogenesis with long-lasting physiological and social behavioral impacts. The aim of this study was to examine the hypothesis that the excess gestational tryptophan may affect children’s mental and physical development via modifying the microbiota-gut-brain axis, which lays the foundation of their mental status. Chicken embryo was employed due to its robust microbiota and independence of maternal influences during embryogenesis. The results indicated that embryonic tryptophan exposure reduced body weight and aggressiveness in the male offspring before and during adolescence. Additionally, the relative gut length and crypt depth were increased, while the villus/crypt ratio was decreased in tryptophan treated roosters, which was corresponding to the changes in the cecal microbiota composition. Furthermore, the catecholamine concentrations were increased in tryptophan group, which may be associated with the alterations in the gut microbiome and the gut-brain axis’s function. These changes may underlie the sociometric status of bullying; clarify how gestational tryptophan fluctuation compromises bullying and provide a strategy to prevent bullying by controlling dietary tryptophan and medication therapy during pregnancy.

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Gut microbiota in mental health and depression: role of pre/pro/synbiotics in their modulation

Abstract: Microbiome residing in the human gut perform a wide range of biological functions. Recently, it has been elucidated that change in the dietary habits is associated with alteration in the...

Cited by 23 publications

References 269 publications

The Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression

The Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression

Role of Microbiota in Viral Infections and Pathological Progression

Embryonic Exposure to Tryptophan Yields Bullying Victimization via Reprogramming the Microbiota-Gut-Brain Axis in a Chicken Model

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