Gut microbiota, hypertension and chronic kidney disease: Recent advances

Sircana, Antonio; Michieli, Franco De; Parente, Renato; Framarin, L.; Leone, Nicola; Berrutti, M; Paschetta, Elena; Bongiovanni, Daria; Musso, Giovanni

doi:10.1016/j.phrs.2018.01.013

Cited by 63 publications

(58 citation statements)

References 254 publications

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“…“Balanced” gut microbiota is critical to maintain the host energy and metabolism equilibrium. Moreover, microbial dysbiosis in the human gut has been recognized as an important risk factor for the development of obesity‐related diseases, including hypertension and T2DM . During the past two decades, accumulative evidence has demonstrated that enteric bacterial products (eg lipopolysaccharides [LPS]) could cross the impaired intestinal barrier to reach peripheral circulation and contributed to the low‐grade chronic inflammatory state .…”

Section: Introductionmentioning

confidence: 99%

Association between blood microbiome and type 2 diabetes mellitus: A nested case‐control study

Qiu

Zhou²,

Yang

et al. 2019

Clinical Laboratory Analysis

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BackgroundAlthough recent studies have indicated that gut microbiome dysbiosis was significantly associated with the onset of type 2 diabetes mellitus (T2DM), information on the role of blood microbiome in T2DM development is scarce.MethodsFifty incident T2DM cases and 100 matched non‐T2DM controls were selected from a prospective cohort study of “135.” The composition of the blood microbiome was characterized using bacterial 16S ribosomal RNA (16S rRNA) gene sequencing from pre‐diagnostic blood sample. The amplicons were normalized, pooled, and sequenced on the Illumina MiSeq instrument using a MiSeq Reagent Kit PE300 v3 kit.ResultsTotally, 3 000 391 and 6 244 227 high‐quality sequences were obtained from T2DM patients and non‐T2DM controls, respectively. The mean diversity of the blood microbiome (Simpson, Chao1 and Shannon indices) was not different between two groups at baseline. At genus level, the Aquabacterium, Xanthomonas, and Pseudonocardia were presented with lower abundance, while Actinotalea, Alishewanella, Sediminibacterium, and Pseudoclavibacter were presented with higher abundance among T2DM cases compared to those in non‐T2DM controls. As the results shown, participants carried the genus Bacteroides in blood were significantly associated with a decreased risk for T2DM development, with 74% vs 88% (adjusted OR: 0.367, 95% CI: 0.151‐0.894). However, participants carried the genus Sediminibacterium have an increased risk for T2DM, with adjusted OR (95% CI) being 14.098 (1.358, 146.330).ConclusionsBlood microbiome may play an etiology role in the development of T2DM. These findings would be useful to develop microbiota‐based strategies for T2DM prevention and control.

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Section: Introductionmentioning

confidence: 99%

Association between blood microbiome and type 2 diabetes mellitus: A nested case‐control study

Qiu

Zhou²,

Yang

et al. 2019

Clinical Laboratory Analysis

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“…In addition, they must be resistant to hydrochloric acid contained in the stomach, digestive enzymes, bile acids. The preparation combining probiotics and prebiotics is called a synbiotic [48,51]. Probiotics may be of natural origin, e.g.…”

Section: Therapeutic Optionsmentioning

confidence: 99%

“…Other potentially beneficial effects of prebiotics depend on the activation of glucagon-like peptide-1 (GLP-1), the YY peptide (PYY-anorexigenic neuropeptide), and other intestinal hormones. They consist in lowering body weight, improving lipid metabolism, and reducing insulin resistance [51]. However, a study conducted in the popu lation of peritoneal dialysis patients proved a lower level of proinflammatory cytokines and endotoxin after a 6-month period of consuming probiotics from the strains of Bifidobacterium and Lactobacillus [39].…”

Section: Therapeutic Optionsmentioning

confidence: 99%

“…Unfortunately, in the study based on completing nutrition questionnaires, no specific type of probiotics was indicated [39,63]. In studies on rats, it has been proved to slow down the progression of kidney disease, and even to prolong the survival after the use of probiotics of the strains of Bacillus pasteurii or Lactobacillus sporogenes [39,51].…”

Section: Therapeutic Optionsmentioning

confidence: 99%

“…In theory, it is possible to deliver bacteria with a modified genome to the gastrointestinal tract of patients, equipped with enzymes breaking down uremic toxins. Currently, there are no practical tests assessing such possibilities [39,41,51].…”

Section: Therapeutic Optionsmentioning

confidence: 99%

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Gut Microbiota In Chronic Kidney Disease

Nalewajska

Przybyciński

Marchelek-Myśliwiec

et al. 2019

Postępy Mikrobiologii - Advancements of Microbiology

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In health, the relationship between gut microflora and the host is of a mutualistic kind. Microbiota offers many benefits to the host, including harvesting energy, regulating host immunity, and the synthesis of vitamins. Alteration in gut microflora can lead to homeostasis disruption and development of various diseases. Dysbiosis is commonly observed in chronic kidney disease (CKD). Nutrient processing by gut microbiota results in the production of some uremic toxins, and these accumulate in CKD causing deleterious effects. Increased permeability of the intestinal barrier, which is also seen in CKD contributes to the development of the uremic state. These factors are associated with chronic inflammation and oxidative stress and therefore are involved in CKD-related complications, including disease progression, cardiovascular disease, anemia, mineral-metabolism, and insulin resistance. This review describes connections between altered gut microflora and development of CKD and its complications, as well as possible therapeutic options. 1. Mikrobiota-krótka charakterystyka. 2. Mechanizmy doprowadzające do jakościowych i ilościowych zmian mikrobioty jelit w prze wlekłej chorobie nerek i ich wpływ na strukturę bariery jelitowej. 3. Przyczyny progresji przewlekłej choroby nerek związane z zaburzeniem mikrobioty jelitowej. 4. Powikłania przewlekłej choroby nerek związane ze zmianą mikrobioty jelitowej. 4.1. Choroby sercowo-naczyniowe. 4.2. Anemia. 4.3. Zaburzenia metabolizmu kostnego. 4.4. Insulinooporność w przewlekłej chorobie nerek. 5. Możliwości terapeutyczne. 6. Podsumowanie

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Analysis of gut microbiota in three species belonging to different genera (Hemitragus, Pseudois, and Ovis) from the subfamily Caprinae in the absence of environmental variance

Sun

Xia

Wei

et al. 2021

Ecology and Evolution

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This study aimed to identify the effects of host species on the gut microbial flora in three species (Hemitragus jemlahicus, Pseudois nayaur, and Ovis orientalis) from the subfamily Caprinae, by excluding the impact of environment factors. We investigated the differences in intestinal flora of three species belonging to Caprinae, which were raised in identical conditions. Fecal samples were collected from tahr, mouflon, and bharal, and the V3–V4 region of the 16S ribosomal RNA gene was analyzed by high‐throughput sequencing. The analysis of 16S rRNA gene sequences reveals that fecal samples were mainly composed of four phyla: Firmicutes, Bacteroidetes, Spirochaetes, and Proteobacteria. The most abundant phyla included Firmicutes and Bacteroidetes accounting for >90% of the bacteria, and a higher Firmicutes/Bacteroidetes ratio was observed in tahrs. Moreover, significant differences existed at multiple levels of classifications in the relative abundance of intestinal flora, differing greatly between species. Phylogenetic analyses based on 16S rRNA gene indicated that mouflon is closely related to bharal, and it is inconsistent with previous reports in the species evolutionary relationships. In this study, we demonstrated that the gut microbiota in tahr had a stronger ability to absorb and store energy from the diet compared with mouflon and bharal, and the characteristics of host–microbiome interactions were not significant.

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Gut microbiota, hypertension and chronic kidney disease: Recent advances

Cited by 63 publications

References 254 publications

Association between blood microbiome and type 2 diabetes mellitus: A nested case‐control study

Association between blood microbiome and type 2 diabetes mellitus: A nested case‐control study

Gut Microbiota In Chronic Kidney Disease

Analysis of gut microbiota in three species belonging to different genera (Hemitragus, Pseudois, and Ovis) from the subfamily Caprinae in the absence of environmental variance

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