Gut Microbiota Eubacterium callanderi Exerts Anti-Colorectal Cancer Activity

Ryu, Seoung Woo; Kim, Jisun; Oh, Byeong Seob; Choi, Won Jung; Yu, Seung Yeob; Bak, Jeong Eun; Park, Seung-Hwan; Kang, Se Won; Lee, Ji-Young; Jung, Won Yong; Lee, Jung-Sook; Lee, Ju Huck

doi:10.1128/spectrum.02531-22

Cited by 9 publications

(6 citation statements)

References 48 publications

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“…In addition, many studies support the beneficial effects of probiotics in CRC prevention and treatment (Ryu et al, 2022;Saeed et al, 2022;Huang et al, 2023). For CRC, the most common probiotics are Lactobacillus and Bifidobacterium, including other genera such as Enterococcus, Streptococcus and Leuconostoc (Zou et al, 2018;Wong and Yu, 2019).…”

Section: Gut Microbiota Omvs Interaction With Host Cellsmentioning

confidence: 99%

The potential role of gut microbiota outer membrane vesicles in colorectal cancer

Meng,

Zeng,

et al. 2023

Front. Microbiol.

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Colorectal cancer (CRC) is a common malignant digestive tract tumor in colorectal regions. Considerable evidence now shows that the gut microbiota have essential roles in CRC occurrence and development. Most Gram-negative bacteria release outer membrane vesicles (OMVs) via outer membrane blistering, which contain specific cargoes which interact with host cells via intercellular communications, host immune regulation, and gut microbiota homeostasis. Studies have also shown that OMVs selectively cluster near tumor cells, thus cancer treatment strategies based on OMVs have attracted considerable research attention. However, little is known about the possible impact of gut microbiota OMVs in CRC pathophysiology. Therefore, in this review, we summarize the research progress on molecular composition and function of OMV, and review the microbial dysbiosis in CRC. We then focus on the potential role of gut microbiota OMVs in CRC. Finally, we examine the clinical potential of OMVs in CRC treatment, and their main advantages and challenges in tumor therapy.

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Section: Gut Microbiota Omvs Interaction With Host Cellsmentioning

confidence: 99%

The potential role of gut microbiota outer membrane vesicles in colorectal cancer

Meng,

Zeng,

et al. 2023

Front. Microbiol.

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“…They are identified as bacteria with anti-inflammatory properties, with studies showing decreased anti-inflammatory effects in mice deficient in Faecalibateria and Eubacteria [ 65 ]. Another study specifically designed to look at candidate strains with anti-CRC activity showed Eubacterium callanderi to have antiproliferative properties against CRC cells by inducing apoptosis and cell death in a dose-dependent manner [ 66 ]. Further, the same study showed higher butyrate concentrations with the peri-tumoral injection of a cell-free supernatant of Eubacteria inhibiting tumor growth, further emphasizing their role in probiotic therapy to prevent CRC [ 66 ].…”

Section: Abnormal Gut Microbiome In Patients With Colorectal Cancermentioning

confidence: 99%

Gut Microbiome–Colorectal Cancer Relationship

Yadav,

Sainatham,

Filippov

et al. 2024

Microorganisms

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Traditionally, the role of gut dysbiosis was thought to be limited to pathologies like Clostridioides difficile infection, but studies have shown its role in other intestinal and extraintestinal pathologies. Similarly, recent studies have surfaced showing the strong potential role of the gut microbiome in colorectal cancer, which was traditionally attributed mainly to sporadic or germline mutations. Given that it is the third most common cancer and the second most common cause of cancer-related mortality, 78 grants totaling more than USD 28 million have been granted to improve colon cancer management since 2019. Concerted efforts by several of these studies have identified specific bacterial consortia inducing a proinflammatory environment and promoting genotoxin production, causing the induction or progression of colorectal cancer. In addition, changes in the gut microbiome have also been shown to alter the response to cancer chemotherapy and immunotherapy, thus changing cancer prognosis. Certain bacteria have been identified as biomarkers to predict the efficacy of antineoplastic medications. Given these discoveries, efforts have been made to alter the gut microbiome to promote a favorable diversity to improve cancer progression and the response to therapy. In this review, we expand on the gut microbiome, its association with colorectal cancer, and antineoplastic medications. We also discuss the evolving paradigm of fecal microbiota transplantation in the context of colorectal cancer management.

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“…The utilization of mono-, di-, and polysaccharides was quanti ed by measuring the production of reducing sugars during growth using a DNS assay [49]. Fermentation products were determined after ve days of cultivation using high-performance liquid chromatography (HPLC), as described previously [50]. The chromatograph of the 5-day culture was compared with that of the 0-hour culture.…”

Section: Physiological Characterizationmentioning

confidence: 99%

Halocynthiibacter laminarini gen. nov., sp. nov. and Halocynthiibacter xylanolyticus sp. nov., marine anaerobic laminarin and xylan degraders in the phylum Bacteroidota

Nguyen,

Vuong,

Han

et al. 2024

Preprint

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The bacterial group of the phylum Bacteroidota greatly contributes to the global carbon cycle in marine ecosystems through its specialized ability to degrade marine polysaccharides. In this study, it is proposed that two novel facultative anaerobic strains, DS1-an-13321T and DS1-an-2312T, which were isolated from a sea squirt, represent a novel genus, Halocynthiibacter, with two novel species in the family Prolixibacteraceae. The 16S rRNA sequence similarities of these two strains were 91.26% and 91.37%, respectively, against Puteibacter caeruleilacunae JC036T, which is the closest recognized neighbor. The complete genomes of strains DS1-an-13321T and DS1-an-2312T each consisted of a single circular chromosome with a size of 4.47 and 5.19 Mb, respectively. The average amino acid identity and the percentage of conserved proteins against the type species of the genera in the family Prolixibacteraceae ranged from 48.33–52.35% and 28.34–37.37%, respectively, which are lower than the threshold for genus demarcation. Strains DS1-an-13321T and DS1-an-2312T could grow on galactose, glucose, maltose, lactose, sucrose, laminarin, and starch, and only DS1-an-2312T could grow on xylose and xylan under fermentation conditions. These strains produced acetic acid and propionic acid as the major fermentation products. Genome mining of the genomes of the two strains revealed 27 and 34 polysaccharide utilization loci, which included 155 and 249 carbohydrate-active enzymes (CAZymes), covering 57 and 65 CAZymes families, respectively. The laminarin-degrading enzymes in both strains were cell-associated, and showed exo-hydrolytic activity releasing glucose as a major product. The xylan-degrading enzymes of strain DS1-an-2312T was also cell-associated, and had endo-hydrolytic activities, releasing xylotriose and xylotetraose as major products. The evidence from phenotypic, biochemical, chemotaxonomic, and genomic characteristics supported the proposal of a novel genus with two novel species in the family Prolixibacteraceae, for which the names Halocynthiibacter laminarini gen. nov., sp. nov. and Halocynthiibacter xylanolyticus sp. nov. are proposed. The type strain of Halocynthiibacter laminarini is DS1-an-13321T (= KCTC 25031T = DSM 115329T) and the type strain of Halocynthiibacter xylanolyticus is DS1-an-2312T (= KCTC 25032T = DSM 115328T).

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Gut Microbiota Eubacterium callanderi Exerts Anti-Colorectal Cancer Activity

Abstract: The gut microbiota has been reported to be involved in colorectal cancer, as suggested by metagenomic analysis. However, metagenomic analysis has limitations, such as bias in the analysis and the absence of bacterial resources for follow-up studies.

Cited by 9 publications

References 48 publications

The potential role of gut microbiota outer membrane vesicles in colorectal cancer

The potential role of gut microbiota outer membrane vesicles in colorectal cancer

Gut Microbiome–Colorectal Cancer Relationship

Halocynthiibacter laminarini gen. nov., sp. nov. and Halocynthiibacter xylanolyticus sp. nov., marine anaerobic laminarin and xylan degraders in the phylum Bacteroidota

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