Gut microbiota dysbiosis induced by polychlorinated biphenyl 126 contributes to increased brain proinflammatory cytokines: Landscapes from the gut-brain axis and fecal microbiota transplantation

Li, Tongtong; Tian, Dongcan; Lu, Mengtian; Wang, Bijiao; Li, Jun; Xu, Baohua; Chen, Hao; Wu, Shijin

doi:10.1016/j.ecoenv.2022.113726

Cited by 12 publications

(4 citation statements)

References 84 publications

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“…Recently, it was demonstrated that not only does PCB exposure alter the gut microbiome, but also that the gut microbiome influences PCB metabolism and disposition. Thus, tissue levels of PCBs were higher in conventional mice with a normal microbiome than in germ-free mice that lack a microbiome following comparable PCB exposures (Li, Tian, et al, 2022). The gut microbiome also altered the gut-liver axis as evidenced by differential patterns of gene expression in the liver of conventional vs. germ-free mice following exposure to a human-relevant PCB mixture (Lim et al, 2020).…”

Section: Pcb Interactions With the Gut Microbiomementioning

confidence: 98%

“…The metabolism of environmental chemicals is also influenced by the gut microbiome (Li, Tian, et al, 2022;Lim et al, 2020;Zimmermann, Zimmermann-Kogadeeva, Wegmann, & Goodman, 2019), and changes in the composition of the gut microbiome have been shown to alter the disposition and concentration of environmental chemicals throughout the body, including the brain (Li, Tian, et al, 2022). Conversely, environmental chemicals can alter the gut microbiome (Gama, Neves, & Pereira, 2022;Lai, Chung, Li, Wan, & Wong, 2016;Li, Hefti, Marek, et al, 2022;Rude, Keogh, & Gareau, 2019).…”

Section: Disruption Of the Gut Microbiomementioning

confidence: 99%

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Gene × environment interactions in autism spectrum disorders

Keil-Stietz

Lein

2023

Current Topics in Developmental Biology

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Section: Pcb Interactions With the Gut Microbiomementioning

confidence: 98%

Section: Disruption Of the Gut Microbiomementioning

confidence: 99%

Gene × environment interactions in autism spectrum disorders

Keil-Stietz

Lein

2023

Current Topics in Developmental Biology

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“…Emerging animal studies have demonstrated that PCB exposure reduces the diversity of gut microbiota and disrupts their community composition ( 14 , 27 – 29 ). Mouse models have shown that PCB 126 exposure is associated with decreased levels of Firmicutes ( 28 ) and increased levels of gram-negative bacteria such as Bacteroidetes ( 28 , 30 ). Furthermore, PCB treatment was associated with elevated levels of lipopolysaccharides in the peripheral circulation and upregulated proinflammatory cytokines in the mouse brain ( 30 ).…”

Section: Introductionmentioning

confidence: 99%

“…Mouse models have shown that PCB 126 exposure is associated with decreased levels of Firmicutes ( 28 ) and increased levels of gram-negative bacteria such as Bacteroidetes ( 28 , 30 ). Furthermore, PCB treatment was associated with elevated levels of lipopolysaccharides in the peripheral circulation and upregulated proinflammatory cytokines in the mouse brain ( 30 ). Non-dioxin-like PCB 153 exposure was linked to the reduced diversity of gut microbiota as well as to the increased abundance of Firmicutes and reduced abundance of Bacteroidetes ( 29 ).…”

Section: Introductionmentioning

confidence: 99%

Anthocyanin-rich blue potato meals protect against polychlorinated biphenyl-mediated disruption of short-chain fatty acid production and gut microbiota profiles in a simulated human digestion model

et al. 2023

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BackgroundPolychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants associated with a wide variety of adverse human health outcomes. PCB 126 and PCB 153 are among the most prevalent congeners associated with human exposure. Emerging studies have suggested that PCB exposure leads to lower gut microbial diversity although their effects on microbial production of health promoting short-chain fatty acids (SCFAs) has been scarcely studied. Blue potatoes are rich in anthocyanins (ACNs), which is a class of polyphenols that promote the growth of beneficial intestinal bacteria such as Bifidobacterium and Lactobacillus and increase the generation of SCFAs. A batch-culture, pH-controlled, stirred system containing human fecal microbial communities was utilized to assess whether human gut microbiota composition and SCFA production are affected by: (a) PCB 126 and PCB 153 exposure; and (b) ACN-rich digests in the presence and absence of the PCB congeners.MethodsAnthocyanin-rich blue potato meals (11.03 g) were digested over 12 h with and without PCB 126 (0.5 mM) and PCB 153 (0.5 mM) using an in vitro simulated gut digestion model involving upper gastrointestinal digestion followed by metabolism by human fecal microbiota. Fecal digests were collected for analysis of gut microbial and SCFA profiles.ResultsPolychlorinated biphenyl-exposed fecal samples showed a significant (p < 0.05) decrease in species richness and a significantly (p < 0.05) different microbial community structure. PCB treatment was associated with an increased (p < 0.05) relative abundance of Akkermansia, Eggerthella, and Bifidobacterium and a decreased (p < 0.05) relative abundance of Veillonella, Streptococcus, and Holdemanella. ACN digests counteracted the altered abundances of Akkermansia and Bifidobacterium seen with the PCB treatment. PCB exposure was associated with a significant (p < 0.05) decrease in total SCFA and acetate concentrations. ACN digests were associated with significantly (p < 0.05) higher SCFA and acetate concentrations in the presence and absence of PCBs.ConclusionHuman fecal matter exposed to PCB 126 and PCB 153 led to decreased abundance and altered gut microbiota profiles as well as lowered SCFA and acetate levels. Importantly, this study showed that prebiotic ACN-rich potatoes counteract PCB-mediated disruptions in human gut microbiota profiles and SCFA production.

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Influence of e-waste exposure on DNA damage and DNA methylation in people living near recycling sites

Wang

et al. 2023

Environ Sci Pollut Res

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The association between long-term exposure to e-waste and poor health is well established, but how e-waste exposure affects DNA methylation is understudied. In this study, we investigated the concentration of PCBs in environmental samples around the e-waste area and measured the DNA damage levels and the alternation of DNA methylation in peripheral blood mononuclear cells (PBMCs) collected from a population exposed to e-waste. There was serious PCB contamination in the soil, water, and plants around the e-waste recycling area. The concentration of 28 PCB congeners in blood samples of ewaste recycling workers was elevated than those of the reference group. DNA damage levels were signi cantly higher than that of samples from the reference group by detecting the SCGE, CA, and CBMN assay. Eventually, we found that the methylation level of 1233 gene loci was changed in the exposure group. Bioinformatic analysis of differential genes revealed that the hypermethylated genes were enriched in cell component movement and regulation of cell function, and hypomethylated genes were involved in the cellular metabolic process. Among the 30 genes we tested, 14 genes showed a negative correlation between methylation level and expression level. Therefore, e-waste exposure potentially increased levels of DNA damage and alters DNA methylation, which would likely impact human health.

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Gut microbiota dysbiosis induced by polychlorinated biphenyl 126 contributes to increased brain proinflammatory cytokines: Landscapes from the gut-brain axis and fecal microbiota transplantation

Cited by 12 publications

References 84 publications

Gene × environment interactions in autism spectrum disorders

Gene × environment interactions in autism spectrum disorders

Anthocyanin-rich blue potato meals protect against polychlorinated biphenyl-mediated disruption of short-chain fatty acid production and gut microbiota profiles in a simulated human digestion model

Influence of e-waste exposure on DNA damage and DNA methylation in people living near recycling sites

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