Gut Microbiota Dysbiosis in Postweaning Piglets: Understanding the Keys to Health

Gresse, Raphaële; Chaucheyras‐Durand, Frédérique; Fleury, Mickaël; Wiele, Tom Van de; Forano, Evelyne; Blanquet‐Diot, Stéphanie

doi:10.1016/j.tim.2017.05.004

Cited by 581 publications

(604 citation statements)

References 115 publications

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“…Notably, the control piglets had a high level of caspase‐1 p10 in the ileum which might be explained that active intestinal mucosal immunization is needed for the protection of newly weaned piglets because they have been deprived of passive lactogenic immunity. Alternatively, newly weaned piglets encountered multiple stressors, weaning causes transient anorexia and gut microbiota dysbiosis which contributes to local inflammation in the small intestine of post‐weaning piglets . It was worth noting that L .…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, newly weaned piglets encountered multiple stressors, weaning causes transient anorexia and gut microbiota dysbiosis which contributes to local inflammation in the small intestine of post-weaning piglets. [26][27][28] It was worth noting that L. johnsonii L531 inhibited the S. infantis-induced activation of caspase-1 in IPEC-J2 cells only at 12 h post-infection. Dependence on caspase-1 for restricting S. typhimurium did not seem absolute and caspase-1 seems to contribute to pathogen restriction in the mucosal epithelium during early infection.…”

Section: Discussionmentioning

confidence: 99%

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Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1‐dependent mitophagy in a Salmonella infantis model of piglet diarrhea

Xia

et al. 2019

FASEB j.

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Newly weaned piglets challenged with Salmonella infantis were particularly susceptible, whereas oral preadministration of Lactobacillus johnsonii L531 alleviated enteritis and promoted intestinal secretory IgA production. Salmonella infantisinduced activation of NLRC4 and NLRP3 inflammasomes and (nuclear factor kappa B) NF-κB signaling in the small intestine was also inhibited by L. johnsonii L531 pretreatment, thus limiting inflammation. An IPEC-J2 cell model of S. infantis infection yielded similar results. Salmonella infantis infection also resulted in mitochondrial damage and impaired mitophagy in the ileum and IPEC-J2 cells, as demonstrated by immunofluorescence colocalization of mitochondria with microtubule-binding protein light chain 3 (LC3) and high expression of autophagy-related proteins PTEN-induced putative kinase 1 (PINK1), sequestosome 1 (SQSTM1/p62), optineurin (OPTN), and LC3 by Western blotting analysis. However, L. johnsonii L531 pretreatment reduced both the extent of mitochondrial damage and autophagyrelated protein expression. Our findings suggest that the amelioration of S. infantisassociated enteritis by L. johnsonii L531 is associated with regulation of NLRC4 and NLRP3 inflammasomes and NF-κB signaling pathway activation and suppression of mitochondrial damage. Amelioration of impaired mitophagy by L. johnsonii L531 could involve eliminating damaged mitochondria and regulating S. infantis-induced activation of the NF-κB-SQSTM1mitophagy signaling pathway in host cells to prevent the further mitochondrial damage and S. infantis dissemination. K E Y W O R D S autophagy, inflammasome, IPEC-J2, pig, probiotic 2822 |

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1‐dependent mitophagy in a Salmonella infantis model of piglet diarrhea

Xia

et al. 2019

FASEB j.

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“…ABX treatments are not the only cause of microbiota dysbiosis in food animals. Nutrition and environmental parameters at birth and during rearing have also been shown to be associated with microbiota dysbiosis (44, 45). In addition, microbiota dysbiosis can also indirectly promote the spread and burden of infectious diseases by impairing the response to vaccines (46–48).…”

Section: Discussionmentioning

confidence: 99%

The Intestinal Microbiota Contributes to the Control of Highly Pathogenic H5N9 Influenza Virus Replication in Ducks

Figueroa

Bessière

Coggon

et al. 2019

Preprint

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“…Moreover, the 62 results obtained in this model are relevant both for the pig industry (e.g. management of post-weaning 63 diarrhea in piglets) and for human health due to the anatomical, functional and microbial similarities 64 between piglet and human infant gastrointestinal tract (Heinritz et al, 2013;Gresse et al, 2017). 65 Numerous studies in piglets described a major shift in the microbiota taxonomic composition and 66 functional capacity at the suckling-to-weaning transition (…”

Section: Introduction 41mentioning

confidence: 97%

Functional maturation of the gut microbiota at weaning is influenced by maternal environment in piglets

Beaumont

Cauquil

Bertide

et al. 2020

Preprint

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13 14 Running title: Metabolic activity of piglet gut microbiota 15 2 ORIGINALITY -SIGNIFICANCE STATEMENT 16Bacterial metabolites are key molecular intermediates between the gut microbiota and host cells. Our 17 study in piglets reveals that the metabolic activity of the gut microbiota shifts at weaning, a key 18 developmental period for intestinal and immune health. We also show that this functional maturation 19 of the gut microbiota is strongly influenced by maternal environment. Thus, targeting early life 20 environmental factors is a promising strategy to program health trough the production of beneficial 21 bacterial metabolites at the suckling-to-weaning transition. 22 from the second maternity farm probably because they already had high relative concentration of short 34 chain fatty acids and higher relative abundance of Christensenellaceae R-7 group and 35Ruminococcaceae UCG-002 during the suckling period. In conclusion, the functional maturation of 36 the microbiota at weaning is highly dependent on the maternal environment in piglets. 37 38 KEY WORDS 39Early life, Milk, Solid food, Metabolites 40 observed only in piglets from one of the two maternity farms studied. In piglets from maternity 1, 126 there was a reduction of the relative abundance of Proteobacteria, Enterobacteriaceae and Escherichia-127Shigella after weaning while the relative abundances of Christensenellaceae, Christensenellaceae R-7 128 group and Ruminococcaceae UCG-002 increased. In piglets from maternity 2, the relative abundance 129 of Peptostreptococcaceae increased after weaning. After weaning (at day 23), the relative abundances 130 of Spirochaetes and Ruminococcaceae UCG-002 were higher in piglets from maternity 2 when 131 compared to piglets from maternity 1 while the opposite was observed for Atopobiaceae. Altogether, 132these results show that both maternal environment and weaning shape the microbiota composition in 133 piglets. 134 135 ACKNOWLEDGMENTS 369

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Gut Microbiota Dysbiosis in Postweaning Piglets: Understanding the Keys to Health

Cited by 581 publications

References 115 publications

Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1‐dependent mitophagy in a Salmonella infantis model of piglet diarrhea

Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1‐dependent mitophagy in a Salmonella infantis model of piglet diarrhea

The Intestinal Microbiota Contributes to the Control of Highly Pathogenic H5N9 Influenza Virus Replication in Ducks

Functional maturation of the gut microbiota at weaning is influenced by maternal environment in piglets

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