Gut Microbiota Defined Epigenomes of Alzheimer’s and Parkinson’s Diseases Reveal Novel Targets for Therapy
Shabnam Nohesara,
Hamid Mostafavi Abdolmaleky,
Sam Thiagalingam
et al.
Abstract:The origins of Alzheimer's disease (AD) and Parkinson's disease (PD) involve genetic mutations, epigenetic changes, neurotoxin exposure and gut microbiota dysregulation. The gut microbiota's dynamic composition and its metabolites influence intestinal and blood–brain barrier integrity, contributing to AD and PD development. This review explores protein misfolding, aggregation and epigenetic links in AD and PD pathogenesis. It also highlights the role of a leaky gut and the microbiota–gut–brain axis in promotin… Show more
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