Gut microbiota composition is associated with temperament traits in infants

Aatsinki, Anna-Katariina; Lahti, Leo; Uusitupa, Henna-Maria; Munukka, Eveliina; Keskitalo, Anniina; Nolvi, Saara; O’Mahony, Siobhain M.; Pietilä, Sami; Elo, Laura L.; Eerola, Erkki; Karlsson, Hasse; Karlsson, Lena

doi:10.1016/j.bbi.2019.05.035

Cited by 97 publications

(150 citation statements)

References 59 publications

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“…In the first, the effects of prematurity on cognitive performance were stronger in boys, who also showed greater improvement with a dietary intervention (Lucas et al, ). In the other (Aatsinki et al, ), associations between microbiota composition and temperament were stronger in boys (Aatsinki et al, , although this sex effect was not observed in a smaller, less well‐powered study examining the same variables; Christian et al, ). Thus, the preliminary findings hint that males may be more vulnerable to the effects of microbiota manipulations on neurodevelopment, in keeping with the pattern of sex differences observed for neurodevelopmental disorders.…”

Section: Clinical Significancementioning

confidence: 97%

“…Two studies, including a recent investigation of a large Finnish cohort, have observed complex, sex‐specific relationships between the microbiota composition and very early temperament, including extraversion, regulation, and fear reactivity (Aatsinki et al, ; Christian et al, ). Gastrointestinal distress, which is associated with disruption of the microbiota, has been shown to predict future anxiety across childhood, even when accounting for initial anxiety (Callaghan et al, in press).…”

Section: Evidence For Microbial Modulation Of Neurocognitive Developmentmentioning

confidence: 99%

“…In fruit flies (Drosophila melanogaster), both developing and mature individuals rely on microbiota-derived volatile compounds as social signals, influencing food and mating preference (Sharon et al, 2010;Venu et al, 2014). This is reminiscent of the associations between microbiota composition and extraversion observed in human infants, as described above (Aatsinki et al, 2019;Christian et al, 2015). Thus, there is a robust relationship between social behavior and the microbiota observed across species.…”

Section: Behavioral and Cognitive Developmentmentioning

confidence: 99%

See 2 more Smart Citations

Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development

Cowan

Dinan

Cryan

2019

Child Psychology Psychiatry

107

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The gut microbiota is a vast, complex, and fascinating ecosystem of microorganisms that resides in the human gastrointestinal tract. As an integral part of the microbiota–gut–brain axis, it is now being recognized that the microbiota is a modulator of brain and behavior, across species. Intriguingly, periods of change in the microbiota coincide with the development of other body systems and particularly the brain. We hypothesize that these times of parallel development are biologically relevant, corresponding to ‘sensitive periods’ or ‘critical windows’ in the development of the microbiota–gut–brain axis. Specifically, signals from the microbiota during these periods are hypothesized to be crucial for establishing appropriate communication along the axis throughout the life span. In other words, the microbiota is hypothesized to act like an expected input to calibrate the development of the microbiota–gut–brain axis. The absence or disruption of the microbiota during specific developmental windows would therefore be expected to have a disproportionate effect on specific functions or potentially for regulation of the system as a whole. Evidence for microbial modulation of neurocognitive development and neurodevelopmental risk is discussed in light of this hypothesis, finishing with a focus on the challenges that lay ahead for the future study of the microbiota–gut–brain axis during development.

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Section: Clinical Significancementioning

confidence: 97%

Section: Evidence For Microbial Modulation Of Neurocognitive Developmentmentioning

confidence: 99%

Section: Behavioral and Cognitive Developmentmentioning

confidence: 99%

See 1 more Smart Citation

Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development

Cowan

Dinan

Cryan

2019

Child Psychology Psychiatry

107

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“…Recent evidence revealed that GM might influence behavior in humans as well. Indeed, GM composition is associated with emotionality and fear reactivity in infants [ 50 ], important traits that have been shown to predict the risk of anxiety and depression. Furthermore, gut bacteria may model human personality traits, with sociability being associated with higher GM diversity, while anxiety and stress is related to reduced diversity [ 51 ].…”

Section: Nutrients Microbiota and Brain Healthmentioning

confidence: 99%

Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration

Gentile

Doneddu

Riva

et al. 2020

IJMS

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Increasing evidence gives support for the idea that extra-neuronal factors may affect brain physiology and its predisposition to neurodegenerative diseases. Epidemiological and experimental studies show that nutrition and metabolic disorders such as obesity and type 2 diabetes increase the risk of Alzheimer’s and Parkinson’s diseases after midlife, while the relationship with amyotrophic lateral sclerosis is uncertain, but suggests a protective effect of features of metabolic syndrome. The microbiota has recently emerged as a novel factor engaging strong interactions with neurons and glia, deeply affecting their function and behavior in these diseases. In particular, recent evidence suggested that gut microbes are involved in the seeding of prion-like proteins and their spreading to the central nervous system. Here, we present a comprehensive review of the impact of metabolism, diet and microbiota in neurodegeneration, by affecting simultaneously several aspects of health regarding energy metabolism, immune system and neuronal function. Advancing technologies may allow researchers in the future to improve investigations in these fields, allowing the buildup of population-based preventive interventions and development of targeted therapeutics to halt progressive neurologic disability.

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“…Of specific relevance to ecological discussions, included in DOHaD findings, is intriguing research that suggests that non-pathogenic microbes (and other aspects of biodiversity) in early life have multisystem consequences through effects on immune development [148]. One of the more fascinating dimensions of this has been revelations that this might even influence subsequent brain development and mental health [149][150][151][152]. When paired with separate research on access/residential proximity to natural environments and healthy birth outcomes (again, setting life-course health) [153,154], the psychobiological implications of rewilding loom large.…”

Section: De-extinction Of Experience Psychobiological Restoration: Mmentioning

confidence: 99%

Spaceship Earth Revisited: The Co-Benefits of Overcoming Biological Extinction of Experience at the Level of Person, Place and Planet

Prescott

Bland²

2020

IJERPH

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Extensive research underscores that we interpret the world through metaphors; moreover, common metaphors are a useful means to enhance the pursuit of personal and collective goals. In the context of planetary health—defined as the interdependent vitality of all natural and anthropogenic ecosystems (social, political and otherwise)—one enduring metaphor can be found in the concept of “Spaceship Earth”. Although not without criticism, the term “Spaceship Earth” has been useful to highlight both resource limitations and the beauty and fragility of delicate ecosystems that sustain life. Rene Dubos, who helped popularize the term, underscored the need for an exposome perspective, one that examines the total accumulated environmental exposures (both detrimental and beneficial) that predict the biological responses of the “total organism to the total environment” over time. In other words, how large-scale environmental changes affect us all personally, albeit in individualized ways. This commentary focuses the ways in which microbes, as an essential part of all ecosystems, provide a vital link between personal and planetary systems, and mediate the biopsychosocial aspects of our individualized experience—and thus health—over our life course journey. A more fine-grained understanding of these dynamics and our power to change them, personally and collectively, lies at the core of restoring “ecosystems balance” for person, place and planet. In particular, restoring human connectedness to the natural world, sense of community and shared purpose must occur in tandem with technological solutions, and will enhance individual empowerment for personal well-being, as well as our collective potential to overcome our grand challenges. Such knowledge can help shape the use of metaphor and re-imagine solutions and novel ways for restoration or rewilding of ecosystems, and the values, behaviors and attitudes to light the path toward exiting the Anthropocene.

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Gut microbiota composition is associated with temperament traits in infants

Cited by 97 publications

References 59 publications

Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development

Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development

Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration

Spaceship Earth Revisited: The Co-Benefits of Overcoming Biological Extinction of Experience at the Level of Person, Place and Planet

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