Gut microbiota composition is altered in a preclinical model of type 1 diabetes mellitus: Influence on gut steroids, permeability, and cognitive abilities

Diviccaro, Silvia; Falvo, Eva; Cioffi, Lucia; Herian, Monika; Brivio, Paola; Calabrese, Francesca; Giatti, Silvia; Caruso, Donatella; Melcangi, Roberto Cosimo

doi:10.1016/j.neuropharm.2022.109405

Cited by 6 publications

(7 citation statements)

References 87 publications

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“…Since Akkermansia is increased by HFD feeding, the detrimental effects of HFD feeding on anxiety could be augmented by Akkermansia and other microbial communities as a result of HFD intake. Interestingly, Akkermansia is increased in a rat model of Type 1 diabetes mellitus in females, providing further support for its association with metabolic and inflammatory perturbation in females 96 . In future studies it will be important to investigate sex differences in the function of Akkermansia and other microbes in behavior.…”

Section: Gut Microbiota Associate With Anxiety-like Behaviormentioning

confidence: 76%

Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice

Acharya

Graham

Raman

et al. 2023

Sci Rep

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Decreased estrogens during menopause are associated with increased risk of anxiety, depression, type 2 diabetes and obesity. Similarly, depleting estrogens in rodents by ovariectomy, combined with a high-fat diet (HFD), increases anxiety and adiposity. How estrogens and diet interact to affect anxiety and metabolism is poorly understood. Mounting evidence indicates that gut microbiota influence anxiety and metabolism. Here, we investigated the effects of estradiol (E) and HFD on anxiety, metabolism, and their correlation with changes in gut microbiota in female mice. Adult C57BL/6J mice were ovariectomized, implanted with E or vehicle-containing capsules and fed a standard diet or HFD. Anxiety-like behavior was assessed and neuronal activation was measured by c-fos immunoreactivity throughout the brain using iDISCO. HFD increased anxiety-like behavior, while E reduced this HFD-dependent anxiogenic effect. Interestingly, E decreased neuronal activation in brain regions involved in anxiety and metabolism. E treatment also altered gut microbes, a subset of which were associated with anxiety-like behavior. These findings provide insight into gut microbiota-based therapies for anxiety and metabolic disorders associated with declining estrogens in menopausal women.

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Section: Gut Microbiota Associate With Anxiety-like Behaviormentioning

confidence: 76%

Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice

Acharya

Graham

Raman

et al. 2023

Sci Rep

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“…76 It has been shown to have anti-inflammatory and immunomodulatory effects, which could potentially help protect against cognitive deficit and dysbiosis in T1D. 77 And reduced levels of allopregnanolone in the peripheral blood or cerebrospinal fluid were found to be associated with depression. 78 In addition, our study discovered the relationship among key microbiota, their related metabolites, and FPG.…”

Section: Discussionmentioning

confidence: 99%

“…Allopregnanolone is a naturally occurring neurosteroid from the hormone progesterone and a positive allosteric modulator of γ‐aminobutyric acid (GABA) 76 . It has been shown to have anti‐inflammatory and immunomodulatory effects, which could potentially help protect against cognitive deficit and dysbiosis in T1D 77 . And reduced levels of allopregnanolone in the peripheral blood or cerebrospinal fluid were found to be associated with depression 78 …”

Section: Discussionmentioning

confidence: 99%

Microbial and metabolomic profiles of type 1 diabetes with depression: A case–control study

Liu,

Yue,

Zheng

et al. 2024

Journal of Diabetes

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BackgroundDepression is the most common psychological disorder in patients with type 1 diabetes (T1D). However, the characteristics of microbiota and metabolites in these patients remain unclear. This study aimed to investigate microbial and metabolomic profiles and identify novel biomarkers for T1D with depression.MethodsA case–control study was conducted in a total of 37 T1D patients with depression (TD+), 35 T1D patients without depression (TD−), and 29 healthy controls (HCs). 16S rRNA gene sequencing and liquid chromatography–mass spectrometry (LC–MS) metabolomics analysis were conducted to investigate the characteristics of microbiota and metabolites. The association between altered microbiota and metabolites was explored by Spearman's rank correlation and visualized by a heatmap. The microbial signatures to discriminate TD+ from TD− were identified by a random forest (RF) classifying model.ResultsIn microbiota, 15 genera enriched in TD− and 2 genera enriched in TD+, and in metabolites, 14 differential metabolites (11 upregulated and 3 downregulated) in TD+ versus TD− were identified. Additionally, 5 genera (including Phascolarctobacterium, Butyricimonas, and Alistipes from altered microbiota) demonstrated good diagnostic power (area under the curve [AUC] = 0.73; 95% CI, 0.58–0.87). In the correlation analysis, Butyricimonas was negatively correlated with glutaric acid (r = −0.28, p = 0.015) and malondialdehyde (r = −0.30, p = 0.012). Both Phascolarctobacterium (r = 0.27, p = 0.022) and Alistipes (r = 0.31, p = 0.009) were positively correlated with allopregnanolone.ConclusionsT1D patients with depression were characterized by unique profiles of gut microbiota and serum metabolites. Phascolarctobacterium, Butyricimonas, and Alistipes could predict the risk of T1D with depression. These findings provide further evidence that the microbiota–gut–brain axis is involved in T1D with depression.image

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“…It is mediated by T cells and characterized by the destruction of islet β-cells, absolute insulin deficiency, and hyperglycemia ( Syed, 2022 ). Multiple studies have shown that, in contrast to the gut microbiota of healthy individuals, that of patients with T1DM is disordered in structure with decreased diversity ( Diviccaro et al., 2023 ; Moreira et al., 2023 ), ultimately manifesting as an increase in the quantity of Bacteroides and a reduction in the quantity of Bifidobacterium , lactic acid , and butyrate-producing bacteria ( Ma et al., 2020 ; Diviccaro et al., 2023 ; Moreira et al., 2023 ). Other studies ( Demirci et al., 2020 ; Yuan et al., 2022 ) have found that, in contrast to those of non-diabetic groups, the proportions of Ackermannia mucosus , Firmicutes , and Clostridium praxobacter, as well as the proportions of Firmicutes and Bacteroides (F/B), were decreased in the T1DM group.…”

Section: Gut Microbiota and Dmmentioning

confidence: 99%

“…Finally, T cells are significant players in adaptive immune responses, both in fighting pathogens and regulating immune responses to maintain immune homeostasis. Therefore, most studies suggest that enteric dysbacteriosis changes intestinal permeability and the intestinal immune response in the pathogenesis of T1DM ( Demirci et al., 2020 ; Huang et al., 2020 ; Ma et al., 2020 ; de Groot et al., 2021 ; He et al., 2022 ; Syed, 2022 ; Wang et al., 2022 ; Xie et al., 2022 ; Yuan et al., 2022 ; Zheng et al., 2022 ; Diviccaro et al., 2023 ; Moreira et al., 2023 ).…”

Section: Role Of Gut Microbiota In the Pathophysiology Of Dmmentioning

confidence: 99%

Advances in fecal microbiota transplantation for the treatment of diabetes mellitus

Zhang,

Wang,

Liu

et al. 2024

Front. Cell. Infect. Microbiol.

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Diabetes mellitus (DM) refers to a group of chronic diseases with global prevalence, characterized by persistent hyperglycemia resulting from various etiologies. DM can harm various organ systems and lead to acute or chronic complications, which severely endanger human well-being. Traditional treatment mainly involves controlling blood sugar levels through replacement therapy with drugs and insulin; however, some patients still find a satisfactory curative effect difficult to achieve. Extensive research has demonstrated a close correlation between enteric dysbacteriosis and the pathogenesis of various types of DM, paving the way for novel therapeutic approaches targeting the gut microbiota to manage DM. Fecal microbiota transplantation (FMT), a method for re-establishing the intestinal microbiome balance, offers new possibilities for treating diabetes. This article provides a comprehensive review of the correlation between DM and the gut microbiota, as well as the current advancements in FMT treatment for DM, using FMT as an illustrative example. This study aims to offer novel perspectives and establish a theoretical foundation for the clinical diagnosis and management of DM.

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Gut microbiota composition is altered in a preclinical model of type 1 diabetes mellitus: Influence on gut steroids, permeability, and cognitive abilities

Cited by 6 publications

References 87 publications

Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice

Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice

Microbial and metabolomic profiles of type 1 diabetes with depression: A case–control study

Advances in fecal microbiota transplantation for the treatment of diabetes mellitus

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