Gut microbiota, circulating inflammatory proteins and sepsis: a bi-directional Mendelian randomization study
Zuming Li,
Liangcai Lin,
Yunqi Kong
et al.
Abstract:BackgroundGut microbiota is closely related to the occurrence and development of sepsis. However, the causal effects between the gut microbiota and sepsis, and whether circulating inflammatory proteins act as mediators, remain unclear.MethodsGut microbiota, circulating inflammatory proteins, and four sepsis-related outcomes were identified from large-scale genome wide association studies (GWAS) summary data. Inverse Variance Weighted (IVW) was the primary statistical method. Additionally, we investigated wheth… Show more
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